Vascular Burden Predicts Gait, Mood, and Executive Function Disturbances in Older Adults with Mild Cognitive Impairment: Results from the Gait and Brain Study

Montero‐Odasso, Manuel; Annweiler, Cédric; Hachinski, Vladimir; Islam, Anam; Toma, Nicola; Vasudev, Akshya

doi:10.1111/j.1532-5415.2012.04180.x

Cited by 44 publications

(7 citation statements)

References 8 publications

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“…Indeed, although some reported an association, others did not[2, 5, 8, 9]. We suggest that divergences previously reported are related to the effect of main confounders previously identified in the literature that may increase STV independently of FOF such as the age, history of falls, cognitive decline and low walking speed[10, 12]. Thus, the question is to determine whether FOF may independently influence or not gait variability among older adults.…”

Section: Introductionmentioning

confidence: 73%

The influence of fear of falling on gait variability: results from a large elderly population-based cross-sectional study

Ayoubi

Launay

Kabeshova

et al. 2014

J NeuroEngineering Rehabil

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ObjectiveTo compare gait variability among older community-dwellers with and without fear of falling and history of falls, and 2) to examine the association between gait variability and fear of falling while taking into account the effect of potential confounders.MethodsBased on a cross-sectional design, 1,023 French community-dwellers (mean age ± SD, 70.5 ± 5.0 years; 50.7% women) were included in this study. The primary endpoints were fear of falling, stride-to-stride variability of stride time and walking speed measured using GAITRite® system. Age, gender, history of falls, number of drugs daily taken per day, body mass index, lower-limb proprioception, visual acuity, use of psychoactive drugs and cognitive impairment were used as covariables in the statistical analysis. P-values less than 0.05 were considered as statistically significant.ResultsA total of 60.5% (n = 619) participants were non-fallers without fear of falling, 19% (n = 194) fallers without fear of falling, 9.9% (n = 101) non-fallers with fear of falling, and 10.7% (n = 109) fallers with fear of falling. Stride-to-stride variability of stride time was significantly higher in fallers with fear of falling compared to non-fallers without fear of falling. Full adjusted linear regression models showed that only lower walking speed value was associated to an increase in stride-to-stride variability of stride time and not fear of falling, falls or their combination. While using a walking speed ≥1.14 m/s (i.e., level of walking speed that did not influence stride-to-stride variability of stride time), age and combination of fear of falling with history of previous falls were significantly associated with an increased stride-to-stride variability of stride time.ConclusionsThe findings show that the combination of fear of falling with falls increased stride-to-stride variability of stride time. However, the effect of this combination depended on the level of walking speed, increase in stride-to-stride variability of stride time at lower walking speed being related to a biomechanical effect overriding fear of falling-related effects.Electronic supplementary materialThe online version of this article (doi:10.1186/1743-0003-11-128) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 73%

The influence of fear of falling on gait variability: results from a large elderly population-based cross-sectional study

Ayoubi

Launay

Kabeshova

et al. 2014

J NeuroEngineering Rehabil

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“…The association between complex walking swing time variability and VaD but not AD, is consistent with the literature that executive dysfunction (assessed by WWT) is a hallmark of early clinical stages of VaD and other non-AD dementias. 7, 38 Cross sectional studies have shown that adults with cognitive impairment due to a variety of neurologic disorders perform worse on complex (dual task) walking. 15, 39–45 Older adults with MCI were reported to decrease gait speed during dual task walking compared to cognitively intact participants.…”

Section: Discussionmentioning

confidence: 99%

Walking While Talking and Risk of Incident Dementia

Ceïde

Ayers

Lipton

et al. 2018

The American Journal of Geriatric Psychiatry

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“…Vascular risk was assessed using the previously validated 7-point Vascular Factors Index (VFI), which includes vascular risk factors (hypertension, dyslipidemia, diabetes mellitus) and diseases (coronary artery disease, stroke, congestive heart failure, atrial fibrillation). 10 Venous blood samples were collected from resting participants for the measurement of serum 25OHD, intact parathyroid hormone (iPTH), and interleukin-8. Pearson correlation and univariate and multiple linear regressions were performed to examine the association between serum 25OHD concentration and OCV.…”

Section: Methodsmentioning

confidence: 99%

Association Between Serum 25‐Hydroxyvitamin D Concentration and Optic Chiasm Volume

Annweiler

Beauchet

Bartha

et al. 2013

J American Geriatrics Society

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In particular, low serum 25-hydroxyvitamin D (25OHD) concentrations are associated with poor visual acuity in older adults. 2 This association has been tentatively explained by the onset of age-related macular degeneration (AMD) in the case of hypovitaminosis D, 3,4 but no causal relationship has been established, 3,4 and other hypotheses have not been tested. For instance, because vitamin D is involved in neurophysiology and neuroprotection, 5-7 it was hypothesized that low 25OHD concentrations could result in optic neuropathy. The optic chiasm is the union of the optic nerves and gives rise to the optic tracts, which synapse in the gray matter of the thalamus. 8 The objective of the current study was to determine whether serum 25OHD concentrations were associated with the volume of the optic chiasm in community-dwelling older adults. METHODSTwenty Caucasian independent community-dwelling older adults (mean age 74.3 AE 6.3; 40.0% female) from the Gait and Brain Study were included in the present analysis. Participants had no family history of optic neuropathy, had no signs of intracranial hypertension, were not addicted to alcohol or smoking, and had never taken anticancer drugs. Written informed consent was obtained at enrollment, and the ethics review board of the University of Western Ontario approved the study. Three-dimensional T 1 -weighted magnetization-prepared rapid-gradient echo sagittal images (acquisition matrix 56 9 240 9 160, field of view 240 9 256 9 192 mm, repetition time 2.3 seconds, echo time 2.91 ms, inversion time 900 ms, flip angle 9, repetitions = 1) were acquired on a 3.0-Tesla magnetic resonance imaging (MRI) scanner (Siemens, Erlangen, Germany). Optic chiasm volume (OCV) and intracranial volume were automatically calculated from these structural images using FreeSurfer software, a set of tools that automatically segments, labels, and quantifies intracranial volumes based on established processing steps (http:// surfer.nmr.mgh.harvard.edu/). 9 No diagnosis of chiasmal compression was made on MRI. All participants received a full medical examination consisting of structured questionnaires and a clinical examination. Evaluation of ophthalmic comorbidities, including a history of AMD or glaucoma or the need for glasses for everyday life, was based on self-report. Vascular risk was assessed using the previously validated 7-point Vascular Factors Index (VFI), which includes vascular risk factors (hypertension, dyslipidemia, diabetes mellitus) and diseases (coronary artery disease, stroke, congestive heart failure, atrial fibrillation). 10 Venous blood samples were collected from resting participants for the measurement of serum 25OHD, intact parathyroid hormone (iPTH), and interleukin-8. Pearson correlation and univariate and multiple linear regressions were performed to examine the association between serum 25OHD concentration and OCV. Age, sex, VFI, history of AMD and glaucoma, need for glasses, intracranial volume, and serum iPTH and interleukin-8 concentrations were used as potential conf...

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Vascular Burden Predicts Gait, Mood, and Executive Function Disturbances in Older Adults with Mild Cognitive Impairment: Results from the Gait and Brain Study

Cited by 44 publications

References 8 publications

The influence of fear of falling on gait variability: results from a large elderly population-based cross-sectional study

The influence of fear of falling on gait variability: results from a large elderly population-based cross-sectional study

Walking While Talking and Risk of Incident Dementia

Association Between Serum 25‐Hydroxyvitamin D Concentration and Optic Chiasm Volume

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