Association Between Serum 25‐Hydroxyvitamin D Concentration and Optic Chiasm Volume

Annweiler, Cédric; Beauchet, Olivier; Bartha, Robert; Graffe, Alix; Miléa, Dan; Montero‐Odasso, Manuel

doi:10.1111/jgs.12249

Cited by 16 publications

(14 citation statements)

References 10 publications

(16 reference statements)

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“…These findings are consistent with the growing epidemiological evidence on the deleterious effect of vitamin D insufficiency on eye health and function [6,7,13,14]. While previous research was primarily focused on macular conditions such as AMD [15,16], only one clinical study focused specifically on the association between vitamin D and POAG [17].…”

Section: Discussionsupporting

confidence: 84%

Serum vitamin D status is associated with the presence but not the severity of primary open angle glaucoma

et al. 2015

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a b s t r a c tObjectives: Vitamin D is involved in visual health and function. Our objective was to determine whether age-related vitamin D insufficiency was associated with the presence and the severity of primary open angle glaucoma (POAG) in a case-control study of older adults. Study design: Case-control study.Main outcome measures. One hundred fifty cases diagnosed with moderate-to-severe POAG (mean, 75.1 ± 8.5 years; 42.0% female) and 164 healthy controls (mean, 73.0 ± 7.9 years; 59.8% female) were included. POAG diagnosis was based on classical diagnostic criteria of optic nerve cupping and/or RNFL thinning, measured with optical coherence tomography. Severe POAG was defined as Humphrey visual field mean deviation (MD) worse than −12 dB. Vitamin D insufficiency was defined as serum 25OHD ≤ 75 nmol/L. Age, gender, mean arterial pressure, vitamin D supplementation, visual acuity, and intraocular pressure were used as potential confounders. Results: POAG cases had lower mean serum 25OHD concentration than controls (42.9 ± 25.7 nmol/L versus 49.4 ± 29.5 nmol/L, P = 0.039) and a greater prevalence of vitamin D insufficiency (90.7% versus 82.3%, P = 0.032). Increased mean serum 25OHD concentrations were associated with lower POAG frequency, even after adjustment for potential confounders (OR = 0.89 per 10 nmol/L of 25OHD, P = 0.045). Similarly, vitamin D insufficiency was associated with POAG (OR = 2.09, P = 0.034). Among POAG cases, no 25OHD difference was observed between moderate and severe POAG cases (respectively, 39.2 ± 23.3 nmol/L versus 45.1 ± 26.7 nmol/L, P = 0.188); and no between-group difference regarding the prevalence of vitamin D insufficiency (88.9% versus 94.0%, P = 0.313). Conclusions: Decreased serum 25OHD concentration was associated with POAG. There was no 25OHD difference between moderate and severe POAG.

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Section: Discussionsupporting

confidence: 84%

Serum vitamin D status is associated with the presence but not the severity of primary open angle glaucoma

et al. 2015

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“…Since the calcarine sulcus is part of the primary visual cortex, which is essential for the conscious treatment of visual stimuli, our result is in agreement with previous epidemiological findings that hypovitaminosis D is associated with reduced visual performance among older adults . This association was tentatively explained by the onset of age‐related macular degeneration (AMD), glaucoma, or optic neuropathy in the case of hypovitaminosis D. However, no causal relationship has been established thus far, and the result of the present study suggests a novel mechanism possibly explaining how vitamin D influences vision, by an effect on the primary visual cortex trophicity rather than on the eye.…”

Section: Discussionsupporting

confidence: 92%

Vitamin D concentration and focal brain atrophy in older adults: a voxel‐based morphometric study

Ali

Labriffe

Navasiolava

et al. 2020

Ann Clin Transl Neurol

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Vitamin D is involved in brain health and function. Our objective was to determine whether lower 25‐hydroxyvitamin D (25OHD) concentration was associated with focal brain volume reduction in older adults. Serum 25OHD concentration was measured among 53 older adults (72 ± 5 years; 38% female; mean 25OHD = 67.3 ± 20.8 nmol/L). Gray matter volume (GMV) was automatically segmented using voxel‐based morphometry with CAT12 software. Covariables were age, gender, education, total intracranial volume, and season. Serum 25OHD was positively associated with GMV in left calcarine sulcus (P < 0.05, TFCE, FWE‐corrected). We found atrophy of the calcarine sulcus with lower 25OHD concentrations in older adults.

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“…Annwelier et al found that the serum 25(OH)D levels were associated with optic chiasm volume [42], and in a vitro experiment, vitamin D was found to inhibit neovascularization in retinal tissue in a model of ischemic retinopathy [13]. What is more, proof of the VDR polymorphisms related with diabetic retinopathy was found.…”

Section: Discussionmentioning

confidence: 99%

The Association between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis of Observational Studies

2017

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Emerging evidence from in vivo and in vitro studies have shown that vitamin D may play an important role in the development of diabetic retinopathy (DR), but individually published studies showed inconclusive results. The aim of this study was to quantitatively summarize the association between vitamin D and the risk of diabetic retinopathy. We conducted a systematic literature search of Pubmed, Medline, and EMBASE updated in September 2016 with the following keywords: “vitamin D” or “cholecalciferol” or “25-hydroxyvitamin D” or “25(OH)D” in combination with “diabetic retinopathy” or “DR”. Fifteen observational studies involving 17,664 subjects were included. In this meta-analysis, type 2 diabetes patients with vitamin D deficiency (serum 25(OH)D levels <20 ng/mL) experienced a significantly increased risk of DR (odds ratio (OR) = 2.03, 95% confidence intervals (CI): 1.07, 3.86), and an obvious decrease of 1.7 ng/mL (95% CI: −2.72, −0.66) in serum vitamin D was demonstrated in the patients with diabetic retinopathy. Sensitivity analysis showed that exclusion of any single study did not materially alter the overall combined effect. In conclusion, the evidence from this meta-analysis indicates an association between vitamin D deficiency and an increased risk of diabetic retinopathy in type 2 diabetes patients.

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Association Between Serum 25‐Hydroxyvitamin D Concentration and Optic Chiasm Volume

Cited by 16 publications

References 10 publications

Serum vitamin D status is associated with the presence but not the severity of primary open angle glaucoma

Serum vitamin D status is associated with the presence but not the severity of primary open angle glaucoma

Vitamin D concentration and focal brain atrophy in older adults: a voxel‐based morphometric study

The Association between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis of Observational Studies

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