Vascular Alterations in Focal Nodular Hyperplasia of the Liver

Travers, Henry; D'Amato, Nicholas A.

doi:10.1093/milmed/143.2.96

Cited by 12 publications

(5 citation statements)

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“…However, we could not to prove any angioarchitectural abnormalities, such as narrowing, obstruction or thrombus in the blood vessels, in the vicinity of the nodules. It has been suggested that the artery-dominant condition causes localized hyperplastic changes of the hepatocytes, and generates nodular lesions such as FNH [35,36]. Morphologic similarity except encapsulation, diffuse capillarization, and iron deposits in our nodules with FNH would be attributable to the similar mechanism in nodular formation.…”

Section: Discussionmentioning

confidence: 52%

Unique hypervascular nodules in alcoholic liver cirrhosis: identical to focal nodular hyperplasia-like nodules?

Nakashima

Kurogi

Yamaguchi

et al. 2004

Journal of Hepatology

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Section: Discussionmentioning

confidence: 52%

Unique hypervascular nodules in alcoholic liver cirrhosis: identical to focal nodular hyperplasia-like nodules?

Nakashima

Kurogi

Yamaguchi

et al. 2004

Journal of Hepatology

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“…The pathogenesis of FNH continues to be controversial. Travers and D'Amato implicated ‘vascular injury’ resulting from high intravascular pressure in portal veins or in arteriovenous malformations 1 . Whelan et al showed angiographic evidence that associates FNH with vascular malformation 2 .…”

Section: Discussionmentioning

confidence: 99%

Focal nodular hyperplasia of the liver: Direct evidence of circulatory disturbances

Kumagai

Masuda²,

Oikawa³

et al. 2000

J of Gastro and Hepatol

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Focal nodular hyperplasia of the liver is a lesion characterized by a well-circumscribed region of hyperplastic liver parenchyma and contains a stellate fibrous scar. The lesion is thought to be because of liver-cell hyperplasia that is caused by focal circulatory disturbances. We describe here a pediatric case of this lesion that provided direct histopathologic evidence of circulatory disturbances. We identified arterial and portal thrombi, as well as recanalization of arteries in the nodule. Hepatic necrosis was also seen in the lesion. We speculate that thrombosis of the hepatic artery and/or portal vein was the cause of hepatic necrosis and that reperfusion following hepatic arterial recanalization resulted in nodule formation. Although there was no stellate scar present in our case, the presence of bile ductular proliferation at the periphery of the nodule was helpful in distinguishing this lesion from adenoma and hepatocellular carcinoma. The early stage of nodular formation may explain the lack of a stellate scar in our case. The patient was treated earlier with actinomycin D and vincristine following surgical excision of Wilms' tumor. It is possible that such chemotherapy contributed to thrombosis in our case.

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“…The nonuniformity of the blood supply has also been hypothesized to be related to the development of other kinds of tumor‐like lesions including nodular regenerative hyperplasia or partial nodular hyperplasia (22). As a cause of this nonuniformity, thrombosis (15), vascular anomalies (23,24), and blockage of the vessel by deformed red blood cells (25) have been suggested.…”

Section: Discussionmentioning

confidence: 99%

Patent Ductus Venosus Associated with Tumor‐Like Lesions of the Liver in a Young Girl

Matsubara,

Sumazaki,

Saitoh

et al. 1996

J. pediatr. gastroenterol. nutr.

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Vascular Alterations in Focal Nodular Hyperplasia of the Liver

Cited by 12 publications

References 0 publications

Unique hypervascular nodules in alcoholic liver cirrhosis: identical to focal nodular hyperplasia-like nodules?

Unique hypervascular nodules in alcoholic liver cirrhosis: identical to focal nodular hyperplasia-like nodules?

Focal nodular hyperplasia of the liver: Direct evidence of circulatory disturbances

Patent Ductus Venosus Associated with Tumor‐Like Lesions of the Liver in a Young Girl

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