SHCC presents with characteristic clinicopathological features and the recognition of SHCC is important for both clinicians and pathologists.

AFP-L3 was related to progression from moderately differentiated to poorly differentiated HCC, whereas PIVKA II was more specific to vascular invasion. PIVKA II is therefore likely to be a useful indicator of vascular invasion.

No abstract

VEGF-C expression is related to the progression of HCC, and VEGF-C expression in tumor casts of the intrahepatic portal/hepatic vein is considered to be a factor indicating recurrence/metastasis sites.

The fusion of PET plus CT images is useful in detecting extrahepatic metastases in HCC and combined HCC/CC patients.