1997
DOI: 10.1016/s1011-1344(97)00108-5
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Vascular actions of ‘caged’ phenylephrine analogs depend on the structure and site of attachment of the 2-nitrobenzyl group

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Cited by 4 publications
(2 citation statements)
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“…Design of Target Structures. Targets were designed by consideration of the photolytic reactivity of related structures, for example, 2-nitrobenzyl-caged tyrosine, serotonin, and phenylephrine . Caged tyrosine is cleaved upon exposure to 350 nm light for 12 h. 4,5-Dimethoxy-2-nitrobenzyl-caged serotonin releases the neurotransmitter upon excitation by 308 or 337 nm laser pulses.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Design of Target Structures. Targets were designed by consideration of the photolytic reactivity of related structures, for example, 2-nitrobenzyl-caged tyrosine, serotonin, and phenylephrine . Caged tyrosine is cleaved upon exposure to 350 nm light for 12 h. 4,5-Dimethoxy-2-nitrobenzyl-caged serotonin releases the neurotransmitter upon excitation by 308 or 337 nm laser pulses.…”
Section: Resultsmentioning
confidence: 99%
“…The 4,5-dimethoxy groups in a caged nitrobenzyl phenylephrine derivative increases the maximum UV absorption wavelength from 272 to 330 nm and suggests electron-rich nitrobenzyl groups can be cleaved from caged compounds at longer wavelengths, an advantage when working in biological systems. Dimethoxy substitution of caged nitrobenzyl phenylephrine also increases the rate of photolysis relative to the unsubstituted nitrobenzyl phenylephrine analogue 22a. This observation supports that electron-releasing benzyl substituents promote photolytic cleavage of 2-nitrobenzyl phenolic ethers.…”
Section: Resultsmentioning
confidence: 99%