Various conjugative plasmids carrying the mcr-5 gene in Escherichia coli isolates from healthy chickens in Paraguay

Nešporová, Kristina; Jamborová, Ivana; Valček, Adam; Medvecký, Matej; Literák, Ivan; Dolejská, Monika

doi:10.1093/jac/dkz317

Cited by 15 publications

(12 citation statements)

References 9 publications

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“…The gene was predominantly on the IncI1/ST113 plasmid of 95 kbp, which also co-harbored bla CTX-M-8 and was mainly linked to E. coli ST457. This plasmid type has been described to discriminate bla CTX-M-8 in E. coli in several countries, including Brazil [99]. In a study by Melgarejo et al in 2018, it was described the circulation of strains of Enterobacteriaceae that carry the resistance gene mcr-1 isolated from hospitalized patients.…”

Section: Paraguaymentioning

confidence: 99%

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mcr-mediated colistin resistance in South America, a One Health approach: a review

Daza-Cardona

Buenhombre

Fontenelle

et al. 2021

Reviews in Medical Microbiology

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Antimicrobial resistance is recognized as one of the most important global human health problems in the 21st century. The balance between clinical need and resistance prevention is further compromised by agricultural antibiotic use as some countries have actively used colistin in animal production. Antimicrobial-resistant microorganisms have been found in humans, food, animals, plants, and the environment (water, soil, and air), and they can move between ecosystems. The problem of antimicrobial resistance is currently seen in the concept: One Health. This approach encourages interdisciplinary collaborative efforts that work locally. The beginnings of the mcr gene's presence in America dates to 2012 and the first report of disseminating the mcr-1 gene was described for Kelp gulls (Larus dominicanus) from Ushuaia, Argentina. It can be associated with the possible dissemination of the gene in the American continent through migratory birds. The mcr-1 gene is disseminated in countries, such as Argentina,

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Section: Paraguaymentioning

confidence: 99%

“…No mcr-2 or mcr-4 genes were identified [101]. Figure 2 shows the most relevant findings of the mcr gene and its variants of different origins and isolates over time [10,44,52,57,59,63,71,77,89,99].…”

Section: Paraguaymentioning

confidence: 99%

mcr-mediated colistin resistance in South America, a One Health approach: a review

Daza-Cardona

Buenhombre

Fontenelle

et al. 2021

Reviews in Medical Microbiology

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“…The mcr-1 -harboring plasmids have been extensively studied and assigned to a large number of incompatibility groups, of which IncHI2, IncX4, and IncI2 were the predominant ones responsible for the dissemination of the mcr-1 gene among E. coli isolates [ 20 ]. Most of the mcr-9 -carrying plasmids were typed to be IncHI2 [ 17 ], while the type of mcr-5 -encoding plasmids was highly diverse [ 8 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Frequent convergence of mcr-9 and carbapenemase genes in Enterobacter cloacae complex driven by epidemic plasmids and host incompatibility

Xue

Chen

et al. 2022

Emerging Microbes & Infections

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Convergence of mcr and carbapenemase genes has been sporadically detected in Enterobacter cloacae complex (ECC) with an upward trend. However, the state of the epidemic and underlying mechanism of such convergence has been poorly understood. In this study, the co-occurrence of MCR and carbapenemases was systematically analyzed in 230 clinical ECC isolates collected between 2000 and 2018 together with a global dataset consisting of 3,559 ECC genomes compiled from GenBank. We identified 48 mcr-9 / mcr-10 -positive isolates (MCR-ECC) (20.9%) in our collection, and a comparable ratio of MCR-ECC (720/3559, 20.2%) was detected in the global dataset. A high prevalence of carbapenemase-producing MCR-ECC (MCR-CREC) was further identified in the MCR-ECC of both datasets (16/48, 33.3%; 388/720, 53.9%), demonstrating a frequent convergence of mcr-9/10 and carbapenemase genes in ECC worldwide. An epidemic IncHI2/2A plasmid with a highly conserved backbone was identified and largely contributed to the dissemination of mcr-9 in ECC worldwide. A highly conserved IncX3-type NDM-1-carrying plasmid and IncN-type IMP-4-carrying plasmid were additionally detected in MCR-CREC isolated in China. Our surveillance data showed that MCR-CREC emerged (in 2013) much later than MCR-ECC (in 2000), indicating that MCR-CREC could be derived from MCR-ECC by additional captures of carbapenemase-encoding plasmids. Tests of plasmid stability and incompatibility showed that the mcr-9/mcr-10 -encoding plasmids with the NDM-1-encoding plasmids stably remained in ECC but incompatible in Escherichia coli , suggesting that the convergence was host-dependent. The findings extend our concern on the convergence of resistance to the last resort antibiotics and highlight the necessity of continued surveillance in the future.

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“…The mcr-6 gene is like a chromosome (63), but other mcr genes are in the form of conjugation plasmids or, ColE-Type mobilized plasmids by helper plasmids (75)(76)(77).…”

Section: Plasmid Resistance To Colistinmentioning

confidence: 99%

New update on molecular determinants of colistin resistance in bacteria

Sedaghat

Khaledi

2022

Mod Med Lab J

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Colistin relates to the polymyxin group of antibiotics. This antibiotic is still used to destroy gram-negative bacteria as a last resort. However, resistance to this antibiotic has been reported and is appearing day by day. Not much information is available on the exact mechanisms of resistance to this antibiotic. Also, not enough information about pharmacokinetics and pharmacodynamics is available, so the optimal dose should be determined to use these antibiotics to prevent the toxic effects of this antibiotic. In current study, additionally to their pharmacokinetics and pharmacodynamics, we have presented current knowledge about the genes and two-component systems that may cause such resistance to polymyxin and colistin.

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Various conjugative plasmids carrying the mcr-5 gene in Escherichia coli isolates from healthy chickens in Paraguay

Cited by 15 publications

References 9 publications

mcr-mediated colistin resistance in South America, a One Health approach: a review

mcr-mediated colistin resistance in South America, a One Health approach: a review

Frequent convergence of mcr-9 and carbapenemase genes in Enterobacter cloacae complex driven by epidemic plasmids and host incompatibility

New update on molecular determinants of colistin resistance in bacteria

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