Varicose Veins

Piazza, Gregory

doi:10.1161/circulationaha.113.008331

Cited by 95 publications

(73 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Хроническая варикозная болезнь нижних конечно-стей в настоящее время остается одной из наиболее ак-туальных медицинских проблем ангиохирургии, фле-бологии, дерматологии и других дисциплин [8], а за-болевание наносит большой социально-экономиче-ский ущерб государствам [4,10], резко ухудшая каче-ство жизни пациентов [6,7]. Варикозно расширенные вены наблюдаются у 25 % женщин и 10 % мужчин [5,9], а основным клиническим проявлением венозно-го варикоза нижних конечностей является боль в ни-жних конечностях, исчезновение или степень умень-шения выраженности которой относятся к критериям эффективности лечения заболевания [2,11].…”

Section: Introductionunclassified

Болевой Синдром При Варикозной Болезни Под Влиянием Эндовенозной Лазерной Абляции

Siniachenko¹,

Melekhovets²

2022

PJS

View full text Add to dashboard Cite

Параллельное с эндовазальной (эндовенозной) лазерной абляцией проведение кроссэктомии повышает аналгетическую эффективность оперативного лечения варикозной болезни нижних конечностей на начальных этапах наблюдения за больными (через 1 неделю). Интегральная динамика физико-химических показателей адсорбционно-реологических свойств венозной крови у больных с кроссэктомией и без таковой не отличается, причем независимо от выполненной кроссэктомии к первому месяцу после лазерной эндовенозной коагуляции происходит нормализация параметров поверхностной вязкости и упругости, модуля вязкоэластичности, улучшение значений объемной вязкости и поверхностной релаксации. Маломощная эндовенозная лазерная абляция с излучением 10 ватт и менее через 4 недели после операции превосходит по аналгетической эффективности выполненное хирургическое лечение варикозной болезни нижних конечностей с излучением в 15 ватт, при этом способствует уменьшению релаксационных свойств сыворотки венозной крови, а интегральные параметры адсорбционно-реологических свойств сыворотки зависят от влияния энергии лазера на длину и площадь просвета стриппинга.

show abstract

Section: Introductionunclassified

Болевой Синдром При Варикозной Болезни Под Влиянием Эндовенозной Лазерной Абляции

Siniachenko¹,

Melekhovets²

2022

PJS

View full text Add to dashboard Cite

show abstract

“…CVD, including varicose veins and chronic venous insufficiency is one of the most common chronic medical condition, affecting around 5%-30% of adult population in the developed countries [9][10][11][12][13][14]. The sheer prevalence of varicose veins and substantial costs of treating late complications such as chronic ulcers contribute to a high burden on health systems, which accounts for a 1%-3% of total health care budget of many Western countries [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Hyperelastic Properties of Platinum Cured Silicones and its Applications in Active Compression

2020

View full text Add to dashboard Cite

This paper presents the fundamental research of design, development, and evaluation of an active compression system consisting of silicone based inflatable mini-bladders, which could be used in applying radial pressure for the treatment of venous disease. The use of mini-bladders will nullify the effect of radius of curvature and provide a higher resolution to the pressure distribution. They are designed with two elastomeric layers and inflation is limited only to one side. The mini-bladders apply a radial force onto the treated surface when inflated, and the pressure inside mini-bladders could be measured using the concept of back pressure, which provides the flexibility to inflate mini-bladders to a predefined pressure. The 3-D deformation profile of the mini-bladders was analysed using finite element method (FEM) and FEM simulations were validated with experimental data, which showed good agreement within pressure region required for the treatment of venous disease. Finally, the pressure transmission characteristics of mini-bladders were evaluated on a biofidellic lower leg surrogate and the results have shown that the mini-bladders could apply a uniform pressure irrespective of the location on the leg with a 60%–70% of inlet pressure successfully transmitted onto the leg surface, while 40%–50% was available after the fat layers.

show abstract

“…Varicosity refers to the presence of tortuous, lengthened, and/or twisted veins, typically in the lower limbs superficial or deep inside [1]. In Western nations, the prevalence of varicose veins reaches up to the half of the adult population [2, 3] and rises significantly with age [4, 5].…”

Section: Introductionmentioning

confidence: 99%

Serum from Varicose Patients Induces Senescence‐Related Dysfunction of Vascular Endothelium Generating Local and Systemic Proinflammatory Conditions

Mikuła-Pietrasik

Uruski

Aniukiewicz

et al. 2016

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Although the role of endothelium in varicose vein development is indisputable, the effect of the pathology on biological properties of endothelial cells remains unclear. Here we examined if the presence of varicose veins affects senescence of endothelial cells (HUVECs) and, if so, what will be the local and systemic outcome of this effect. Experiments showed that HUVECs subjected to serum from varicose patients display improved proliferation, increased expression of senescence marker, SA-β-Gal, and increased generation of reactive oxygen species (ROS), as compared with serum from healthy donors. Both increased SA-β-Gal activity and ROS release were mediated by TGF-β1, the concentration of which in varicose serum was elevated and the activity of which in vitro was prevented using specific neutralizing antibody. Senescent HUVECs exposed to varicose serum generated increased amounts of ICAM-1, VCAM-1, P-selectin, uPA, PAI-1, and ET-1. Direct comparison of sera from varicose and healthy donors showed that pathological serum contained increased level of ICAM-1, VCAM-1, P-selectin, uPA, and ET-1. Calendar age of healthy subjects correlated positively with serum uPA and negatively with P-selectin. Age of varicose patients correlated positively with ICAM-1, VCAM-1, and ET-1. Collectively, our findings indicate that the presence of varicose veins causes a senescence-related dysfunction of vascular endothelium, which leads to the development of local and systemic proinflammatory environment.

show abstract

Varicose Veins

Cited by 95 publications

References 22 publications

Болевой Синдром При Варикозной Болезни Под Влиянием Эндовенозной Лазерной Абляции

Болевой Синдром При Варикозной Болезни Под Влиянием Эндовенозной Лазерной Абляции

Hyperelastic Properties of Platinum Cured Silicones and its Applications in Active Compression

Serum from Varicose Patients Induces Senescence‐Related Dysfunction of Vascular Endothelium Generating Local and Systemic Proinflammatory Conditions

Contact Info

Product

Resources

About