VARIATIONS OF AIRWAY RFSISTANCE IN PROVOCATION TESTS ON ASTHMATIC PATIENTS, MEASURED WITH DIFFERENT METHODS<sup>1</sup>

Colldahl, Helge; Holmgren, A.; Pegelow, Kjell-Orvar; Svanborg, Nils

doi:10.1111/j.1398-9995.1964.tb03254.x

Cited by 15 publications

(4 citation statements)

References 8 publications

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“…Total respiratory resistance has been shown to reflect airway resistance in large part (24); this finding has been supported by the reports of others (10,25). In the present study, Rrs when related to Vtg was a more sensitive indicator than PEF or FEVl' a finding that also supports the work of others (4,26); however, Rrs was not more sensitive than the volume-corrected flow measure, "60' Bouhuys and Van de Woestijne (8) described 2 patterns of response among hemp workers after dust exposure. In one group, RV increased, maximal flows decreased, and airway conductance changed very little.…”

Section: Discussionsupporting

confidence: 93%

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Maximal Expiratory Flow and Total Respiratory Resistance During Induced Bronchoconstriction in Asthmatic Subjects^1–³

Olive¹,

Hyatt²

1972

Am Rev Respir Dis

102

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_ Fifteen mild to moderate attacks of asthma were induced in 12 asymptomatic asthmatic subjects by nebulization of an allergen. Serial measurements were made of maximal expiratory flow-volume curves and total respiratory resistance; both were related to absolute lung volume. At the height of the attack, total lung capacity was unchanged, vital capacity decreased, residual volume increased, maximal flows decreased, and resistance increased. Maximal flow at 60 per cent of control total lung capacity was the most sensitive indicator of response. Total respiratory resistance corrected for volume was also sensitive and tended to change with maximal flow at 60 per cent of total lung capacity. In many subjects, the first effect of the inhaled allergen was to cause a parallel shift in the maximal expiratory flow-volume curve, with no change in slope. The mechanical explanation for this behavior is uncertain. A possible explanation is that closure of susceptible lung units occurred but the mechanical behavior of uninvolved units was unaffected.

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Section: Discussionsupporting

confidence: 93%

“…by measuring maximal expiratory flows from a forced vital capaci ty maneuver or by recording peak expiratory flow. In a (Received for publication January 15,1972) few instances, more detailed studies of lung mechanics have been performed (4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Maximal Expiratory Flow and Total Respiratory Resistance During Induced Bronchoconstriction in Asthmatic Subjects^1–³

Olive¹,

Hyatt²

1972

Am Rev Respir Dis

102

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“…As shown by Colldahl et al and others (12,13,14), the sensitivity of the methods varies when concerned with the registration of positive provocation tests. Thus, FEVi.o and peak flow usually decline more markedly than the vital capacity (41) when a provocation test is positive.…”

mentioning

confidence: 98%

Mould Allergy

Ripe

1966

Allergy

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“…Following the administration of a variety of bronchoactive agents, changes have been studied in ventilation (Colldahl, Holmgren, Pegelow & Svanborg, 1964;Stanescu, Teculescu, Pacararu & Popa, 1968), mechanical function (McIlroy & Marshall, 1956;Constantine, Dautrebande, Kaltrieder, Lovejoy, Morrow & Perkins, 1959; Dautrebande, Lovejoy & Constantine, 1960;Lovejoy, Constantine, Flatley, Kaltrieder & Dautrebande, 1961 ;Dubois & Dautrebande, 1958;Bouhuys, Hunt, Kim & Zapletal, 1969;Cade, Woolcock, Rebuck & Pain, 1971), ventilationblood-flow relationships (Raine & Bishop, 1964;Norris & Bishop, 1966) and gas transfer (Bouhuys, Georg, Jonsson, Lundin & Lindell, 1960;Stanescu & Teculescu, 1969).…”

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confidence: 99%

Lung Function in Provoked Asthma: Responses to Inhaled Urea, Methacholine and Isoprenaline

Cade

Pain

1972

Clinical Science

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1. Lung function was studied in fifty-six symptom-free asthmatic subjects after the inhalation of urea, an agent not previously used for asthma provocation. The effects of urea were compared with those produced by the inhalation of methacholine and of isoprenaline.2. After urea ventilatory capacity was impaired in 68% of subjects and improved in 16%. This response was a relatively constant phenomenon in the same subject. Urea appears to possess the unusual property of being able to produce both bronchoconstriction and bronchodilatation. The response could not be related to any of the clinical or other physiological variables examined.3. Mild hypoxaemia, ventilation-blood-flow inequality and impairment of gas transfer also occurred after urea administration.4. Methacholine produced considerable impairment of ventilatory capacity with consistent hyperinflation but with variable changes in ventilatory pattern and distribution of ventilation. 5. Isoprenaline rapidly and completely reversed the changes which occurred after urea and methacholine administration.

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VARIATIONS OF AIRWAY RFSISTANCE IN PROVOCATION TESTS ON ASTHMATIC PATIENTS, MEASURED WITH DIFFERENT METHODS¹

Cited by 15 publications

References 8 publications

Maximal Expiratory Flow and Total Respiratory Resistance During Induced Bronchoconstriction in Asthmatic Subjects^1–³

Maximal Expiratory Flow and Total Respiratory Resistance During Induced Bronchoconstriction in Asthmatic Subjects^1–³

Mould Allergy

Lung Function in Provoked Asthma: Responses to Inhaled Urea, Methacholine and Isoprenaline

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VARIATIONS OF AIRWAY RFSISTANCE IN PROVOCATION TESTS ON ASTHMATIC PATIENTS, MEASURED WITH DIFFERENT METHODS1

Cited by 15 publications

References 8 publications

Maximal Expiratory Flow and Total Respiratory Resistance During Induced Bronchoconstriction in Asthmatic Subjects1–3

Maximal Expiratory Flow and Total Respiratory Resistance During Induced Bronchoconstriction in Asthmatic Subjects1–3

Mould Allergy

Lung Function in Provoked Asthma: Responses to Inhaled Urea, Methacholine and Isoprenaline

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VARIATIONS OF AIRWAY RFSISTANCE IN PROVOCATION TESTS ON ASTHMATIC PATIENTS, MEASURED WITH DIFFERENT METHODS¹

Maximal Expiratory Flow and Total Respiratory Resistance During Induced Bronchoconstriction in Asthmatic Subjects^1–³

Maximal Expiratory Flow and Total Respiratory Resistance During Induced Bronchoconstriction in Asthmatic Subjects^1–³