Variations in Serum Potassium and Serum Cholinesterase Activity After Induction with Althesin®‐Suxamethonium and Thiopentone‐Suxamethonium

Abstract

The changes in serum potassium and serum cholinesterase during induction of anaesthesia by thiopentone or Althesin" followed by suxamethonium were studied. We found a significant fall in serum potassium after induction of anaesthesia and a significant increase after suxamethonium with both agents, but there were no significant differences between the two agents.The activity of serum cholinesterase did not show any significant variation from normal during the time of observation.

In Vitro Study of Interactions Between I.V. Anaesthetics and Neuromuscular Blocking Agents

“…However, some authors have suggested that propanidid intensifies the actions of suxamethonium by interference with biotransformation (Torda, Burkhart and Toh, 1972) although Ellis (1968) could not demonstrate this in vitro and Doenicke (1965) noted that the inhibition of cholinesterase by propanidid was extremely transient. In man, Althesin has no detectable cholinesterase-inhibiting activity (Wisborg, Hanel and Viby, 1974). Whilst the present study has not been able to determine the exact mechanism by which certain anaesthetic drugs potentiate neuromuscular blocking agents, it is clear that Althesin behaves differently from the other three.…”

Διαταραχές ηλεκτρολυτών (ΚΝaCl) μετά από χορήγηση αποπολωτικού στα παιδιά

“…Αντίθετα, τα βαρβιτουρικά έχει βρεθεί ότι προκαλούν ελάτ τωση του Κ και του Na του πλάσματος και έτσι αντισταθμίζουν την προκαλούμενη από την Σκχ αύξηση του Κ (202,203,204,208…”