Variations in serum concentrations of penicillin after injections of aqueous procaine penicillin G with and without oral probenecid.

Letter: Effect on incubating syphilis of penicillin treatment for gonorrhoea.

“…However, Cornelius, Schroeter, Lester, and Martin (1971) found approximately 8-fold variations in blood levels in patients receiving 2-4 m.u. aqueous procaine penicillin.…”

Treatment of acute gonococcal urethritis in Bangkok, Thailand.

“…Meads, Knight, and Izlar (1951) and Frisk, Diding, and Wallmark (1952) have reported that the enhancement of serum penicillin levels by probenecid is dose-related up to 4 g., and Boger and Strickland (1955) suggested that toxicity as a result of shortterm administration of this drug was minimal. Recently, Cornelius, Schroeter, Lester, and Martin (1971) and the British Medical J7ournal (1968) (quoting unpublished observations of F. R. Curtis) reported that the use of 2 g. probenecid in combination with large doses of procaine penicillin caused no serious side-effects. We therefore increased the dose of probenecid to 2 g. and gave 4 8 m.u.…”

Treatment of gonorrhoea with procaine penicillin plus probenecid.

“…Investigations carried out on the serum penicillin concentration of patients undergoing combined penicillin and probenecid treatment (White, Conch, Foster, Galloway, Hunter, and Knight, 1965;Evans, 1966;Schmidt and Roholt, 1965;Cornelius, Schroeter, Lester, and Martin, 1971) have given varying results, probably because of differences in the methods used in combining probenecid with penicillin and the use of different types of penicillin.…”