Variations in response to trauma and hippocampal subfield changes

Postel, Charlotte; Mary, Alison; Dayan, Jacques; Fraisse, Florence; Vallée, Thomas; Guillery‐Girard, Bérengère; Viader, Fausto; Sayette, Vincent de La; Peschanski, Denis; Eustache, Francis; Gagnepain, Pierre

doi:10.1016/j.ynstr.2021.100346

Cited by 24 publications

(41 citation statements)

References 84 publications

(135 reference statements)

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“…An overview of the literature review for psychosocial factors and their associations with hippocampal subfield volumes are displayed in Table 1 . Of the 47 articles, 27 studies (57%) reported lower hippocampal subfield volumes in the presence of a psychosocial factor, specifically depression (Averill et al, 2017 ; Choi et al, 2017 ; Doolin et al, 2018 ; Frodl, Carballedo, et al, 2014 ; Frodl, Skokauskas, et al, 2014 ; Han et al, 2016 ; Han et al, 2019 ; Huang et al, 2013 ; Mikolas et al, 2019 ; Postel et al, 2021 ; Su et al, 2016 ; Travis et al, 2015 ; Treadway et al, 2015 ; Wisse et al, 2015 ; Zhou et al, 2020 ), anxiety (Takaishi et al, 2021 ), or childhood maltreatment or post‐traumatic stress disorder (PTSD) (Aghamohammadi‐Sereshki et al, 2021 ; Ahmed‐Leitao et al, 2019 ; Averill et al, 2017 ; Chalavi et al, 2015 ; Chen et al, 2018 ; Hayes et al, 2017 ; Janiri et al, 2019 ; Lim et al, 2012 ; Luo et al, 2017 ; Postel et al, 2021 ; Wang et al, 2010 ; Yuan et al, 2020 ; Zhang et al, 2021 ). The most often affected subfields were the CA3 and DG.…”

Section: Resultsmentioning

confidence: 99%

“…Most of the studies used 1.5T or 3T MRI, with four studies (9%) using high‐field 7T MRI (Brown et al, 2019 ; Kraus et al, 2019 ; Tannous et al, 2020 ; Wisse et al, 2015 ). Twenty‐four studies (51%) reported no significant differences in volume (Abbott et al, 2014 ; Brown et al, 2019 ; Burhanoglu et al, 2021 ; Cao et al, 2017 ; Chalavi et al, 2015 ; Frodl, Carballedo, et al, 2014 ; Han et al, 2016 ; Hansen et al, 2021 ; Hu et al, 2019 ; Kakeda et al, 2018 ; Lim et al, 2012 ; Lindqvist et al, 2014 ; Liu et al, 2021 ; Na et al, 2014 ; Na et al, 2018 ; Ota et al, 2017 ; Postel et al, 2021 ; Szymkowicz et al, 2017 ; Tannous et al, 2020 ; Taylor et al, 2020 ; Travis et al, 2015 ; Travis et al, 2016 ; Weis et al, 2021 ; Yuan et al, 2020 ), and four studies (9%) found increased volumes, specifically in the left hippocampal amygdala transition area (HATA) for sexual abuse (Ahmed‐Leitao et al, 2019 ), the hippocampal tail in those with major depressive disorder (MDD) (Maller et al, 2018 ), the CA1, CA3, and molecular layer in those with childhood maltreatment (Mikolas et al, 2019 ), and in the right subiculum in those with MDD (Kraus et al, 2019 ). No studies assessed recent stressful life events or social support.…”

Section: Resultsmentioning

confidence: 99%

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Psychosocial factors and hippocampal subfields: The Medea‐7T study

Twait

Blom

Koek

et al. 2022

Human Brain Mapping

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Specific subfields within the hippocampus have shown vulnerability to chronic stress, highlighting the importance of looking regionally within the hippocampus to understand the role of psychosocial factors in the development of neurodegenerative diseases. A systematic review on psychosocial factors and hippocampal subfield volumes was performed and showed inconsistent results, highlighting the need for future studies to explore this relationship. The current study aimed to explore the association of psychosocial factors with hippocampal (subfield) volumes, using high‐field 7T MRI. Data were from the Memory Depression and Aging (Medea)‐7T study, which included 333 participants without dementia. Hippocampal subfields were automatically segmented from T2‐weighted images using ASHS software. Generalized linear models accounting for correlated outcomes were used to assess the association between subfields (i.e., entorhinal cortex, subiculum, Cornu Ammonis [CA]1, CA2, CA3, dentate gyrus, and tail) and each psychosocial factor (i.e., depressive symptoms, anxiety symptoms, childhood maltreatment, recent stressful life events, and social support), adjusted for age, sex, and intracranial volume. Neither depression nor anxiety was associated with specific hippocampal (subfield) volumes. A trend for lower total hippocampal volume was found in those reporting childhood maltreatment, and a trend for higher total hippocampal volume was found in those who experienced a recent stressful life event. Among subfields, low social support was associated with lower volume in the CA3 (B = −0.43, 95% CI: −0.72; −0.15). This study suggests possible differential effects among hippocampal (subfield) volumes and psychosocial factors.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Psychosocial factors and hippocampal subfields: The Medea‐7T study

Twait

Blom

Koek

et al. 2022

Human Brain Mapping

View full text Add to dashboard Cite

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“…Traumatic stressors have also been shown to alter hippocampal dendritic morphology and inhibit neurogenesis in the hippocampus [ 42 , 44 , 45 , 46 ]. Chronic stress rapidly reduces the number of dendritic spines and branches of pyramidal neurons in the Cornu Ammonis subfield 3 (CA3) and compromises the integrity of CA1, which is involved in the persistence and re-experiencing of traumatic memories [ 47 , 48 ]. For example, early magnetic resonance imaging studies demonstrated smaller hippocampal volumes in Vietnam Veterans with PTSD compared with controls [ 49 , 50 , 51 , 52 , 53 ].…”

Section: Resultsmentioning

confidence: 99%

A Neurobiological Framework for the Therapeutic Potential of Music and Sound Interventions for Post-Traumatic Stress Symptoms in Critical Illness Survivors

Pant

Frishkopf

Park

et al. 2022

IJERPH

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Overview: Post traumatic stress disorder (PTSD) has emerged as a severely debilitating psychiatric disorder associated with critical illness. Little progress has been made in the treatment of post-intensive care unit (ICU) PTSD. Aim: To synthesize neurobiological evidence on the pathophysiology of PTSD and the brain areas involved, and to highlight the potential of music to treat post-ICU PTSD. Methods: Critical narrative review to elucidate an evidence-based neurobiological framework to inform the study of music interventions for PTSD post-ICU. Literature searches were performed in PubMed and CINAHL. The Scale for the Assessment of Narrative Review Articles (SANRA) guided reporting. Results: A dysfunctional HPA axis feedback loop, an increased amygdalic response, hippocampal atrophy, and a hypoactive prefrontal cortex contribute to PTSD symptoms. Playing or listening to music can stimulate neurogenesis and neuroplasticity, enhance brain recovery, and normalize stress response. Additionally, evidence supports effectiveness of music to improve coping and emotional regulation, decrease dissociation symptoms, reduce depression and anxiety levels, and overall reduce severity of PTSD symptoms. Conclusions: Despite the lack of music interventions for ICU survivors, music has the potential to help people suffering from PTSD by decreasing amygdala activity, improving hippocampal and prefrontal brain function, and balancing the HPA-axis.

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“…Sections were mounted, dried, and stained with cresyl violet. Here we report data obtained for the dentate gyrus of the dorsal hippocampus; an area related to emotional reactions ( Ballesteros et al, 2014 ; Postel et al, 2021 ). Images of the area of interest were taken with an optic microscope (MEIJI MT4200H) and a digital camera Canon (EOS—850D) of 20Mp.…”

Section: Methodsmentioning

confidence: 99%

Behavioral effects of environmental enrichment on male and female wistar rats with early life stress experiences

et al. 2022

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Exposure to adverse childhood experiences or early life stress experiences (ELSs) increase the risk of non-adaptive behaviors and psychopathology in adulthood. Environmental enrichment (EE) has been proposed to minimize these effects. The vast number of methodological variations in animal studies underscores the lack of systematicity in the studies and the need for a detailed understanding of how enrichment interacts with other variables. Here we evaluate the effects of environmental enrichment in male and female Wistar rats exposed to adverse early life experiences (prenatal, postnatal, and combined) on emotional (elevated plus maze), social (social interaction chamber), memory (Morris water maze) and flexibility tasks. Our results—collected from PND 51 to 64—confirmed: 1) the positive effect of environmental enrichment (PND 28–49) on anxiety-like behaviors in animals submitted to ELSs. These effects depended on type of experience and type of enrichment: foraging enrichment reduced anxiety-like behaviors in animals with prenatal and postnatal stress but increased them in animals without ELSs. This effect was sex-dependent: females showed lower anxiety compared to males. Our data also indicated that females exposed to prenatal and postnatal stress had lower anxious responses than males in the same conditions; 2) no differences were found for social interactions; 3) concerning memory, there was a significant interaction between the three factors: A significant interaction for males with prenatal stress was observed for foraging enrichment, while physical enrichment was positive for males with postnatal stress; d) regarding cognitive flexibility, a positive effect of EE was found in animals exposed to adverse ELSs: animals with combined stress and exposed to physical enrichment showed a higher index of cognitive flexibility than those not exposed to enrichment. Yet, within animals with no EE, those exposed to combined stress showed lower flexibility than those exposed to both prenatal stress and no stress. On the other hand, animals with prenatal stress and exposed to foraging-type enrichment showed lower cognitive flexibility than those with no EE. The prenatal stress-inducing conditions used here 5) did not induced fetal or maternal problems and 6) did not induced changes in the volume of the dentate gyrus of the hippocampus.

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Variations in response to trauma and hippocampal subfield changes

Cited by 24 publications

References 84 publications

Psychosocial factors and hippocampal subfields: The Medea‐7T study

Psychosocial factors and hippocampal subfields: The Medea‐7T study

A Neurobiological Framework for the Therapeutic Potential of Music and Sound Interventions for Post-Traumatic Stress Symptoms in Critical Illness Survivors

Behavioral effects of environmental enrichment on male and female wistar rats with early life stress experiences

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