Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep–wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats

Léna, Isabelle; Parrot, Sandrine; Deschaux, Olivier; Muffat-Joly, S.; Sauvinet, Valérie; Renaud, Bernard; Suaud-Chagny, Marie-Françoise; Gottesmann, Claude

doi:10.1002/jnr.20602

Cited by 295 publications

(199 citation statements)

References 45 publications

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“…Thus, we propose that REM sleep neural pathways are only activated when D 2 dopamine receptors are activated on a background of reduced mesolimbic glutamatergic and serotonergic tone. Importantly, this is consistent with neurotransmitters levels observed during REM sleep (Trulson and Jacobs, 1979;Park et al, 1999;Lena et al, 2005), and during the waking period of DAT-KO mice immediately after exposure to novelty (Gainetdinov et al, 1999(Gainetdinov et al, , 2001). This also predicts that psychosis may be generated by pharmacological agents that activate the D 2 dopamine receptor while altering specific aspects of glutamatergic or serotonergic transmission (Kapur and Seeman, 2002;Seeman et al, 2005).…”

Section: Discussionsupporting

confidence: 84%

“…REM is characterized by prominent hippocampal theta oscillations (Vanderwolf, 1969;Timo-Iaria et al, 1970;Cantero et al, 2003) that are highly correlated with dreaming (Aserinsky and Kleitman, 1953;Dement and Kleitman, 1957a,b;Jouvet et al, 1959). Furthermore, recent evidence suggests that REM is also characterized by an increase in mesolimbic dopamine release (Lena et al, 2005). This is consistent with our results, which demonstrate that the pathological REM-like hippocampal theta oscillations are modulated by antipsychotic and psychotomimetic agents that alter dopaminergic transmission.…”

supporting

confidence: 93%

“…Additionally, muscle activity is primarily inhibited during REM sleep, with the exception of eye movements in humans and whisker movements in rodents (Aserinsky and Kleitman, 1953;Dement and Kleitman, 1957a,b;Jouvet et al, 1959). Although the mean firing rate of dopaminergic neurons does not change significantly throughout the sleep-wake cycle (Miller et al, 1983), REM sleep is also characterized by an increase in dopamine release (Maloney et al, 2002;Lena et al, 2005). Together with the sleep disturbances displayed by individuals with altered dopaminergic transmission, this evidence further supports the hypothesis that dopamine plays an important role in regulating the sleepwake cycle.…”

Section: Introductionsupporting

confidence: 52%

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Dopaminergic Control of Sleep–Wake States

et al. 2006

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Section: Discussionsupporting

confidence: 84%

supporting

confidence: 93%

Section: Introductionsupporting

confidence: 52%

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Dopaminergic Control of Sleep–Wake States

et al. 2006

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“…The 5-HT2A receptor indirectly controls glutamatergic signaling. Furthermore, slow wave sleep and REM sleep are generally associated with decreased glutamate levels (58), and antagonism of NMDA receptors increases delta power in NREM sleep in rats (59). With regard to the functional consequences of these regulatory processes, we found that sleep deprivation led to an increase in the 5-HT2Areceptors.…”

Section: Discussionmentioning

confidence: 74%

The impact of sleep deprivation on hippocampal-mediated learning and memory in rats

Saygın¹,

Özgüner²,

Önder³

et al. 2017

BLL

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BACKGROUND: To examine the impact of different types of sleep deprivation on hippocampal-mediated learning and memory in rats. METHODS: Forty-eight Sprague-Dawley male rats were randomly assigned to 1 of 4 equal-size groups: (1) 12 hours of sleep per day (control). (2) total sleep deprivation (TSD), (3) rapid eye movement (REM) deprivation (RD), and (4) sleep restricted to 4 hours per day (SR). All rats were subjected to swimming training in the Morris water maze (MWM). At the end of the experiments, the rats were decapitated, and hippocampus tissue was analyzed for several neurotransmitters and receptors. RESULTS: The time spent at the target quadrant increased from 20.2 to 30.0 seconds in the control group on the third day of the experiment, whereas corresponding values increased from 20.2 to 21.8 seconds in the TSD group, 22.1 to 25.4 seconds in the RD group, and 21.2 to 32.0 sec in the SR group (p = 0.026). On the seventh day of the experiment, the values decreased to 25.0 seconds in controls, 22.5 in the RD group, and 23.6 in the SR group (p = 0.045). The TSD group demonstrated signifi cant decreases in glutamate and serotonin levels compared with the control group. There was a signifi cant increase in 5-HT2 a receptor expression in all intervention groups compared with the controls. CONCLUSIONS: Our results of glutamate levels and 5-HT2a receptor expression in the hippocampus seem to be primarily involved in sleep and memory regulation (Tab. 2, Fig. 4, Ref. 59). Text in PDF www.elis.sk.

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“…Dopamine (DA) has been identified as a key substance in the regulation of sleep-wake states (1)(2)(3)(4)(5)(6)(7). DA is critically involved in regulating complex movements and emotions (8).…”

Section: Introductionmentioning

confidence: 99%

Gentle handling temporarily increases c-Fos in the substantia nigra pars compacta

Santos

Andersen

Lima

et al. 2008

Braz J Med Biol Res

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Dopaminergic neurotransmission is involved in the regulation of sleep. In particular, the nigrostriatal pathway is an important center of sleep regulation. We hypothesized that dopaminergic neurons located in substantia nigra pars compacta (SNpc) could be activated by gentle handling, a method to obtain sleep deprivation (SD). Adult male C57/BL6J mice (N = 5/group) were distributed into non-SD (NSD) or SD groups. SD animals were subjected to SD once for 1 or 3 h by gentle handling. Two experiments were performed. The first determined the activation of SNpc neurons after SD, and the second examined the same parameters after pharmacologically induced dopaminergic depletion using intraperitoneal reserpine (2 mg/kg). After 1 or 3 h, SD and NSD mice were subjected to motor evaluation using the open field test. Immediately after the behavioral test, the mice were perfused intracardially to fix the brain and for immunohistochemical analysis of c-Fos protein expression within the SNpc. The open field test indicated that SD for 1 or 3 h did not modify motor behavior. However, c-Fos protein expression was increased after 1 h of SD compared with the NSD and 3-h SD groups. These immunohistochemistry data indicate that these periods of SD are not able to produce dopaminergic supersensitivity. Nevertheless, the increased expression of c-Fos within the SNpc suggests that dopaminergic nigral activation was triggered by SD earlier than motor responsiveness. Dopamine-depleted mice (experiment 2) exhibited a similar increase of c-Fos expression compared to control animals indicating that dopamine neurons are still activated in the 1-h SD group despite the exhaustion of dopamine. This finding suggests that this range (2-5-fold) of neuronal activation may serve as a marker of SD.

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Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep–wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats

Cited by 295 publications

References 45 publications

Dopaminergic Control of Sleep–Wake States

Dopaminergic Control of Sleep–Wake States

The impact of sleep deprivation on hippocampal-mediated learning and memory in rats

Gentle handling temporarily increases c-Fos in the substantia nigra pars compacta

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