Variations in drug free fraction during alcohol withdrawal.

Sandor, Paul; Naranjo, Claudio A.; Khouw, V; Sellers, E. A.

doi:10.1111/j.1365-2125.1983.tb01533.x

Cited by 11 publications

(6 citation statements)

References 12 publications

(15 reference statements)

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“…Our results of higher propranolol concentrations at the onset of AW than after the resolution of AW symptoms are in line with those of Sandor et al [30], who found elevated levels in concentrations of free propranolol in plasma during withdrawal syndrome. Another factor may be related to changes in hepatic blood flow or in the metabolism of the drug during the first passage through the liver.…”

Section: Discussionsupporting

confidence: 82%

Alcohol Withdrawal Changes Cardiovascular Responses to Propranolol Challenge

Kähkönen

2003

Neuropsychobiology

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The cardiovascular effects and plasma concentrations of a single dose of propranolol (80 mg) were studied non-invasively in alcohol-dependent subjects during alcohol withdrawal (AW) on day 1 and after resolution of withdrawal symptoms on day 10. At the onset of AW, propranolol caused a bradycardic effect which was significantly weakened on day 10. This might result from an increased bioavailability of propranolol on day 1 and from marked sympathetic activity. Propranolol also produced a negative inotropic effect, relatively weaker on day 1 than on day 10, being associated with increased β-receptor sensitivity towards the final phase of AW. These results suggest that peripheral and central β-adrenergic systems modulate the cardiovascular system in AW.

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Section: Discussionsupporting

confidence: 82%

Alcohol Withdrawal Changes Cardiovascular Responses to Propranolol Challenge

Kähkönen

2003

Neuropsychobiology

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“…An increase in the free fraction of thiopentone was observed in patients with alcoholic cirrhosis (Pandele et al, 1983). An increase in the free fatty acids in alcoholic patients may displace acidic drugs from their binding to albumin (Sandor et al, 1983). In the present study, the plasma protein binding of thiopentone was not studied.…”

Section: Discussionmentioning

confidence: 69%

Thiopentone Pharmacokinetics in Patients With Chronic Alcoholism

Couderc

Ferrier

Haberer

et al. 1984

British Journal of Anaesthesia

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The pharmacokinetics of thiopentone were compared in nine control patients and 10 patients with chronic alcoholism (without signs of cirrhosis or hepatitis) undergoing orthopaedic or abdominal surgery under general anaesthesia. The mean (+/- SD) alcohol intake was 92 +/- 14 litre of ethanol per year in the alcoholic patients and less than 10 litre yr-1 in the controls. Thiopentone plasma concentrations were measured by high pressure liquid chromatography after the administration of a single bolus dose (5-9 mg kg-1). The plasma clearance of thiopentone was significantly increased from 3.7 +/- 0.9 ml min-1 kg-1 in the controls to 5.4 +/- 2.2 ml min-1 kg-1 in the patients with chronic alcoholism. The volume of the central compartment and the total apparent volume of distribution were similar in both groups. The terminal elimination half-life was of 684 +/- 168 min in the alcoholics and did not differ significantly from the value found in the controls (750 +/- 212 min).

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“…Total concentrations of propranolol were higher during withdrawal than after resolution of the withdrawal symptoms (Kähkönen, 2003), but concentrations of unbound fraction of propranolol were opposite (Sandor et al, 1983).…”

Section: Discussionmentioning

confidence: 97%