Cardiovascular effects of propranolol in patients with alcohol dependence during withdrawal

Kähkönen, Seppo; Бондаренко, Б. Б.; Lipsanen, Jari; Zvartau, Edwin

doi:10.1016/j.ijpsycho.2007.07.006

Cited by 3 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, propranolol relieves morning withdrawal symptoms and stress in human alcoholics (Carlsson and Johansson 1971; Tyrer 1972). Propranolol also suppresses withdrawal tremor in human alcoholics (Koller et al 1985), and the ability of propranolol to antagonize peripheral effects of alcohol withdrawal in alcoholic humans is at least partly predicted by prior daily alcohol consumption (Kähkönen et al 2007). These effects of propranolol occur in the absence of effects on blood-alcohol elimination rates in humans (Korri 1990).…”

Section: Discussionmentioning

confidence: 99%

Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats

Gilpin

Koob

2010

Psychopharmacology

View full text Add to dashboard Cite

Rationale-Alcohol-dependent animals display enhanced stress responsivity, reward thresholds, and alcohol self-administration during alcohol withdrawal, and some of these aspects of alcohol dependence may be mediated by activation of brain norepinephrine (NE) systems.Objectives-This study examined the effects of propranolol, a β-adrenoceptor antagonist, on operant alcohol-reinforced responding by alcohol-dependent and non-dependent rats.Methods-Adult male Wistar rats were trained to respond for alcohol in an operant conditioning paradigm on fixed-ratio-1 (FR-1) and progressive ratio (PR) reinforcement schedules. Rats were either made dependent on alcohol via chronic intermittent (14 h ON/10 h OFF) alcohol vapor inhalation or were not exposed to alcohol vapor. Rats were tested for the effects of propranolol (0-10 mg/kg) or nadolol (0-20 mg/kg) on operant alcohol-reinforced responding at the time point corresponding to 6-8 h withdrawal in dependent animals.Results-All doses of propranolol suppressed FR-1 operant alcohol-reinforced responding in alcohol-dependent rats, but only the highest dose suppressed FR-1 responding by controls. No dose of propranolol affected water responding. Nadolol did not affect operant behavior. Propranolol suppressed PR operant alcohol-reinforced responding across groups, an effect attributable to significant suppression of alcohol responding at the highest dose.Conclusions-Following development of alcohol dependence, rats exhibit hypersensitivity to the suppressive effects of propranolol on operant alcohol-reinforced responding. This effect is mediated by central actions of the drug, is not attributable to motor effects, and may reflect activation of brain NE systems that contributes to withdrawal-induced negative emotional states and drives alcohol drinking in the dependent organism. KeywordsAlcohol; Dependence; Withdrawal; Propranolol; Norepinephrine; Beta-adrenoceptors Compulsive alcohol drinking behavior is motivated by positive reinforcing effects of alcohol and the negative reinforcement associated with alcohol dependence, the latter of which is hypothesized to be prominent in drinkers with long-term high-dose alcohol histories (Koob and LeMoal 1997). The negative reinforcement motivational properties of alcohol are contingent on the negative affective state that defines alcohol withdrawal (Koob and LeMoal 1997). Alcohol-dependent animals display enhanced stress responsivity, increased reward © Springer-Verlag 2010 Correspondence to: Nicholas W. Gilpin, nickg@scripps.edu. NIH Public AccessAuthor Manuscript Psychopharmacology (Berl). Author manuscript; available in PMC 2011 October 1. Published in final edited form as:Psychopharmacology (Berl). 2010 October ; 212(3): 431-439. doi:10.1007/s00213-010-1967-8. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript thresholds, and increased alcohol self-administration during acute withdrawal and protracted abstinence from chronic high-dose alcohol exposure (Gilpin et al. 2008;Roberts et al. 2000;Schulteis e...

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats

Gilpin

Koob

2010

Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…One possible system involved in cardiovascular actions of verapamil might be monoamines (although the site of the verapamil effect is not clear), which have been shown to modulate WS-mediated cardiovascular symptoms [20] . Schröder and Herzig [21] showed that cardiac L-type Ca 2+ channels in rat cardiomyocytes can be stimulated by activation of ␤ -adrenoreceptors.…”

Section: Discussionmentioning

confidence: 99%

“…Hierarchical linear models were selected as an analysis method instead of the more standard repeated measures ANOVA, because hierarchical linear models can handle randomly assigned missing value patters in the WS group and simultaneously model the baseline mean difference between groups. Day (1, 2, 10 and early recovery) and time before and after verapamil administration (3,10,20,30 and 45 min) served as within-subject variables. The covariance structure of within-subject variables was first-order autoregressive.…”

Section: Statisticsmentioning

confidence: 99%

Effects of Verapamil, an Antagonist of L-Type Calcium Channels, on Cardiovascular Symptoms in Alcohol Withdrawal

Kähkönen¹,

Бондаренко²,

Lipsanen

et al. 2008

Neuropsychobiology

View full text Add to dashboard Cite

Aims: We studied whether verapamil, a Ca²⁺ channel blocker, affects cardiovascular symptoms in alcohol withdrawal. Methods: Cardiovascular effects of verapamil (5 mg intravenously) were compared in 20 alcohol-dependent subjects during alcohol withdrawal (n = 10) on days 1, 2 and 10 and during early recovery (n = 10; duration 45 ± 4.1 days). The heart rate was obtained from the electrocardiogram. Systolic and diastolic blood pressures were measured with a sphygmomanometer by Korotkoff. Stroke volume was studied by impedance cardiography. Results: Significant differences in verapamil effects on systolic and diastolic blood pressure and stroke volume and total peripheral resistance were observed in patients with withdrawal when compared with those in early recovery. Conclusion: L-type Ca²⁺ channels may modify vascular tone in alcohol withdrawal.

show abstract

Impaired cerebral autoregulation during acute alcohol withdrawal

Jochum¹,

Reinhard²,

Boettger³

et al. 2010

Drug and Alcohol Dependence

View full text Add to dashboard Cite

Cardiovascular effects of propranolol in patients with alcohol dependence during withdrawal

Cited by 3 publications

References 18 publications

Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats

Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats

Effects of Verapamil, an Antagonist of L-Type Calcium Channels, on Cardiovascular Symptoms in Alcohol Withdrawal

Impaired cerebral autoregulation during acute alcohol withdrawal

Contact Info

Product

Resources

About