Variations in Chemical Composition, Vasorelaxant and Angiotensin I‐Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae)

Abstract

The present paper describes environmental and seasonal-related chemical composition variations, vasorelaxant and angiotensin I-converting enzyme (ACE) activities of essential oil from aerial parts of Seseli pallasii BESSER. The composition was analyzed by GC and GC/MS. Monoterpenes were found to be the most abundant chemical class with a-pinene (42.7 -48.2%) as the most prevalent component. Seseli pallasi essential oil relaxed isolated endothelium-intact mesenteric arteries rings precontracted with phenylephrine with IC 50 = 3.10 nl/ml (IC 50 = 2.70 lg/ ml). Also, S. pallasii essential oil was found to exhibit a dose-dependent ACE inhibitory activity with an IC 50 value of 0.33 mg/ml. In silico evaluation of ACE inhibitory activity of the individual components showed that spathulenol exhibited the best binding affinity with ACE, and the lowest binding energy of À7.5 kcal/mol. The results suggested that combination of vasorelaxing and ACE inhibitory effects of the analyzed S. pallasii essential oil might have the potential therapeutic significance in hypertension.

The Effects of Coriandrum sativum L. and Chaerophyllum macropodum Boiss. (Apiaceae) on human plasma angiotensin-converting enzyme (ACE) in vitro

“…They detected IC50 value as 1.7 mg/mL [53]. Suručić et al (2017) reported that essential oil of S.pallasii showed dose-dependent inhibition capacity on ACE with an IC50 value of 0.33 mg/mL [54]. In contrast to the results from our work, Saleem et al (2017) stated that ethanol and water extracts of seeds of dill, ajowan, fennel, coriander, and anise from Apiaceae family did not show an inhibition effect on ACE [55].…”

Chemical composition and cytotoxic potency of essential oil from Seseli petraeum M. Bieb. (Apiaceae)

“…Essential oils from Seseli L. species have been previously examined, and germacrene D (29.8%), sabinene (10.3%), (Z)-β-ocimene (9.8%) and limonene (8.6%)] on S. annuum L. [39]; sabinene (17.7-25.1%) on S. buchtormense (Fischer) W. D. J. Koch [40]; α-pinene (26.2% and 35.8%), (E)-sesquilavandulol (11.8% and 3.2%) on S. campestre Besser fruits [41]; α-pinene (38.6±0.5%), β-pinene (17.5±0.1%) and (E)-sesquilavandulol (10.3±0.8%) on S. campestre Besser aerial parts [42]; myrcene (29.2%), α-pinene (18.6%, 21.2%), β-pinene (13.2%, 14.2%) and limonene (10.6%)] on S. tortuosum L. [43][44]; α-pinene (42.7-48.2%) on S. pallasii Besser [45]; αpinene (23.3-37.8%), sabinene (12.9-14.2%), β-phellandrene (5.1-17.4%) on S. rigidum Waldst. & Kit.…”

Angiotensin I-converting Enzyme (ACE) Inhibitory Activity and Chemical Composition of Alchemilla Viridiflora Rothm.

“…Molecules obtained from various plant isolates have gained great interest as ACE inhibitors recently. The most promising compounds based on their structure difference could be divided in tannins, avonoids, essential oil [5,44]. Although structurally different, all these compounds have in common presence of functional groups which serve as hydrogen (H) bond acceptors or donors, such as phenolic and carboxylic.…”

“…Examination of substances of plant origin with ACE inhibitory activity shows that avonoids and peptides are the most active ACE inhibitors [4]. Regarding essential oils, few studies have studied the effects of these secondary metabolites on ACE inhibition [5][6][7][8]. Also, tannins are found to be non-speci c inhibitors of ACE, through sequestration of the enzyme metal cofactor (Zn 2+ ), precipitation of protein or as non-speci c enzyme (trypsin and chymotrypsin) inhibitors [9].…”