Variations in APOE Genotype Distribution in Children from Areas with Different Adult Cardiovascular Disease Mortality in Spain

Garcés, Cármen; Cantos, Míriam; Benavente, Mercedes; Granizo, Juan José; Cano, Beatriz; Viturro, Enrique; Oya, Manuel de

doi:10.1353/hub.2004.0055

Cited by 11 publications

(10 citation statements)

References 16 publications

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“…Since the APOE4/4 genotype is poorly represented in our southern Spanish samples, this allele frequency could be primarily due to the relevant presence of E3/4 heterozygotes (n ¼ 30) and then to E2/4 (n ¼ 5). Comparatively, we observe that the occurrence of E2/4 is somewhat higher in the east of Andalusia than in other Iberian territories (Garcés et al, 2004;Gómez-Coronado et al, 1999;Schiele et al, 2000).…”

Section: Genotypic and Allelic Profiles Analysiscontrasting

confidence: 53%

New insights into the distribution ofAPOEpolymorphism in the Iberian Peninsula. The case of Andalusia (Spain)

Reales

Hernández

Dugoujon

et al. 2014

Annals of Human Biology

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Section: Genotypic and Allelic Profiles Analysiscontrasting

confidence: 53%

New insights into the distribution ofAPOEpolymorphism in the Iberian Peninsula. The case of Andalusia (Spain)

Reales

Hernández

Dugoujon

et al. 2014

Annals of Human Biology

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“…public vs. private). In the present study, children from Orense and Murcia, areas with the lowest and the highest cardiovascular mortality, respectively, 26–30 were analysed. All the subjects were free of endocrine, metabolic, hepatic or renal disorders.…”

Section: Methodsmentioning

confidence: 99%

The serum levels of the EGF‐like homeotic protein dlk1 correlate with different metabolic parameters in two hormonally different children populations in Spain*

Hermida

Garcés

Oya

et al. 2008

Clinical Endocrinology

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“…The molecular basis of ApoE polymorphism is attributed to the amino acid substitutions in position 112 and 158 [8]. Among these genotypes, E3/E3 is the wild type and overwhelming in different populations with evident ethnic heterogeneity [9–11]. In general, individuals with the E2 allele tend to have lower levels, whereas individuals with E4 allele have higher levels of serum cholesterol in comparison to individuals who are homozygous for the E3 allele [12–14].…”

Section: Introductionmentioning

confidence: 99%

Variable Frequencies of Apolipoprotein E Genotypes and Its Effect on Serum Lipids in the Guangxi Zhuang and Han Children

Qin

Lei

et al. 2011

IJMS

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Guangxi Zhuang, the largest ethnic minority in China, is located in the southern part of the country, and well-known to the world as the longevity village. Studies of apolipoprotein E (APOE) polymorphism in adults suggest the lower frequencies of E4 allele and E4/E4 genotype may account, in part, for the favorable lipid profiles of Guangxi Zhuang. However, the effect of APOE polymorphism on serum lipids in the Guangxi Zhuang children is yet unknown to date. In the present study, genomic DNA was extracted from 278 Guangxi Zhuang and 200 Guangxi Han children. APOE genotypes were determined by PCR-restriction fragment length polymorphism (RFLP) analysis. The fasting serum lipoprotein a [Lp(a)], total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (apoA1) and apoB were measured. Our results demonstrated that no significant differences in serum lipids were observed between the Guangxi Zhuang and Han children. The E4/E4 and E4/E3 genotypic frequencies were significantly lower in the Guangxi Zhuang children compared with the Guangxi Han children, whereas for E2/E2, E3/E2 and E4/E2 genotypic frequencies the opposite was presented. Though no significant differences in serum lipid concentrations were found for variant alleles both in the Guangxi Zhuang and Han children, the trend was observed in the association of higher levels of Lp(a), TC, TG and LDL-C with E4 allele in the Guangxi Zhuang children. In conclusion, a significant heterogeneity in APOE genetic variation indeed exists between the Guangxi Zhuang and Han ethnic group. The E4 allele may serve as a genetic marker for susceptibility to higher lipid profiles in the Guangxi Zhuang children. Lifestyle should be modified, according to APOE polymorphism even in the young children.

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Variations in APOE Genotype Distribution in Children from Areas with Different Adult Cardiovascular Disease Mortality in Spain

Cited by 11 publications

References 16 publications

New insights into the distribution ofAPOEpolymorphism in the Iberian Peninsula. The case of Andalusia (Spain)

New insights into the distribution ofAPOEpolymorphism in the Iberian Peninsula. The case of Andalusia (Spain)

The serum levels of the EGF‐like homeotic protein dlk1 correlate with different metabolic parameters in two hormonally different children populations in Spain*

Variable Frequencies of Apolipoprotein E Genotypes and Its Effect on Serum Lipids in the Guangxi Zhuang and Han Children

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