Variation of Specificity of Autoantibodies in Autoimmune Hemolytic Anemia

Beck, Malcolm L.; Dixon, Janet; Oberman, Harold A.

doi:10.1093/ajcp/56.4.475

Cited by 3 publications

(2 citation statements)

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“…Whereas the autoantibody initially was monospecific, subsequent studies revealed a "nonspecific" component. Beck et al 2 have reported sequential changes in autoantibody specificity in a patient with autoimmune hemolytic anemia, and the present patient manifested similar features. Although the "non-specific" antibody reacted only weakly with Rh null cells, it did not have U-specificity.…”

Section: Case Reportsupporting

confidence: 80%

An Autoantibody with U‐specificity in a Patient with Myasthenia Gravis

Beck

Butch

et al. 1972

Transfusion

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Lack of reactivity of IgG autoantibodies with Rhnull red blood cells does not necessarily imply specificity directed towards the Rh system. Recent reports have indicated that occasionally the autoantibodies of warm antibody type hemolytic anemia may have U‐specificity. This report describes an example of auto‐anti‐U occurring in a patient with myasthenia gravis who had no evidence of hemolysis.

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Section: Case Reportsupporting

confidence: 80%

An Autoantibody with U‐specificity in a Patient with Myasthenia Gravis

Beck

Butch

et al. 1972

Transfusion

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“…The transient nature of the autoanti-E is not unusual in patients with autoimmune hemolytic anemia. 18 Autoantibody specificity has been found to change with time in many patients studied. 19 The initial autoantibody frequently has a relatively simple specificity that gradually broadens until the autoantibody reacts with all RBCs.…”

Section: Discussionmentioning

confidence: 99%

Development of Alloanti-Jka in a Patient with Hemolytic Anemia Due to Autoanti-Jkb

Grishaber

Cordle

Strauss

1992

American Journal of Clinical Pathology

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Autoanti-Jkb and a transient autoanti-E were identified in a patient with autoimmune hemolytic anemia, and red blood cells negative for Jk b and E antigens were transfused. Twelve weeks after transfusion, the autoantibody appeared to have developed broad specificity. However, autoadsorption studies revealed that the broad reactivity was due to the development of alloanti-Jk" in addition to the autoanti-Jk Routine detection of an autoantibody with activity against a specific red blood cell (RBC) antigen is unusual in autoimmune hemolytic anemia, and the autoantibody eventually develops broad specificity in many of these patients. ' We report a patient with hemolytic anemia due to autoanti-Jk CASE REPORTA 38-year-old white woman was admitted to the University of Iowa Hospitals and Clinics for a total hip replacement due to complications

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Specificity of Autoantibodies

Petz

2004

Immune Hemolytic Anemias

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Variation of Specificity of Autoantibodies in Autoimmune Hemolytic Anemia

Cited by 3 publications

References 0 publications

An Autoantibody with U‐specificity in a Patient with Myasthenia Gravis

An Autoantibody with U‐specificity in a Patient with Myasthenia Gravis

Development of Alloanti-Jka in a Patient with Hemolytic Anemia Due to Autoanti-Jkb

Specificity of Autoantibodies

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