Variation of muscle tone in the human colon

Steadman, Charles; Phillips, Sidney F.; Camilleri, Michael; Haddad, Anne C.; Hanson, Russell B.

doi:10.1016/0016-5085(91)90014-c

Cited by 129 publications

(55 citation statements)

References 11 publications

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“…The results presented are therefore based on the duration and frequen cy of phasic contractions. An action of laxa tives on muscle tone cannot be excluded but very little is known about this parameter at the colonic level [14], Sennosides and Na-picosulfate are two dif ferent laxatives sharing the property of being metabolized into the active compound by the colonic flora only [15], Laxation starts in rats with a delay of 2-3 h. Other laxatives are already active in the small intestine and our results cannot be extended to those.…”

Section: -Icontrasting

confidence: 42%

In vivo Motility of Rat Colon Chronically Pretreated with Sennosides

Fioramonti¹,

Dupuy²,

Buéno³

1993

Pharmacology

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Ceco-colonic myoelectrical activity was investigated in rats pretreated for 23 weeks by sennosides (10 or 40 mg/kg/day), Na-picosulfate (2.5 or 10 mg/kg/day) or laxative vehicle (control). On the last week of treatment the animals were equipped with Nichrome electrodes on the cecum, the proximal and distal colon. In comparison with controls, sennoside or Na-picosulfate treatment did not induce any significant (p > 0.05) change in the duration of long spike bursts (LSB) which are associated with phasic contractions. On the last 2 days of treatment the frequency of LSB for 2 h before and 2 h after laxative administration, as well as for 30 min after a 3-gram meal was not significantly (p > 0.05) different in control and treated animals. Similarly, on the first 2 days, as well as on days 13 and 14, after the end of treatment, no significant (p > 0.05) difference in the LSB frequency appeared between control and treated animals, in the fasted state or after a 3-gram meal. It is concluded that long-term treatment with sennosides or Na-picosulfate does not induce chronic changes in colonic motility in rats.

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Section: -Icontrasting

confidence: 42%

In vivo Motility of Rat Colon Chronically Pretreated with Sennosides

Fioramonti¹,

Dupuy²,

Buéno³

1993

Pharmacology

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“…11 However, the underlying pathophysiology is incompletely understood. Several studies report that meal intake can stimulate colonic motor activity, 21,22 change visceral sensitivity, 23,24 and lead to the symptoms in IBS patients. In our preliminary study, we found that cold stimulation to the rectal and abdominal wall had varied effects on symptoms and visceral perception thresholds in patients with IBS.…”

Section: Discussionmentioning

confidence: 99%

Visceral hypersensitivity following cold water intake in subjects with irritable bowel syndrome

Zuo

Shi

et al. 2006

J Gastroenterol

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“…Eating stimulate different colonic and motor activity that might explain postprandial gastrointestinal symptoms [30,31,32,33,34,35].…”

Section: Discussionmentioning

confidence: 99%

Sex differences in dietary coping with gastrointestinal symptoms

Faresjö¹,

Johansson

Faresjö³

et al. 2010

European Journal of Gastroenterology &Amp; Hepatology

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Aim Nutritional changes are often considered first line treatment in public health diseases which apply to many gastrointestinal disorders, since different food and beverages may modulate gastrointestinal (GI) motor and sensory functions, and provoke GI symptoms. The aim of this study was to examine dietary coping and possible changes of food and beverages intakes in relation to GI symptoms reported by identified IBS patients compared to healthy controls and if any gender differences were seen in these respects.Methods A population-based case-control design was used. Three primary health care centres in the city of Linköping in Sweden. The IBS cases were recruited from the studied primary health care centres based on diagnoses from computerized medical records. The controls were randomly selected from the general population in the same region. A questionnaire was used with specific questions about self-reported food and beverages increase or decrease of GI symptoms and self-reported changes in dietary habits.Results Female IBS-cases appear to be more willing to change dietary habits due to their GI-problems than males. Effects of these nutritional behaviour changes were reported for almost all participants that had made dietary adjustments. Fatty food, certain vegetables, dairy products and egg were significantly more reported to cause GI complaints among IBS-cases compared to their controls.Conclusions Female IBS-cases reported more changes in their dietary habits due to GI-problems than males with the disease. The majority of both females and males that changed their dietary habits due to GI problems experienced symptoms improvement.

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Variation of muscle tone in the human colon

Cited by 129 publications

References 11 publications

In vivo Motility of Rat Colon Chronically Pretreated with Sennosides

In vivo Motility of Rat Colon Chronically Pretreated with Sennosides

Visceral hypersensitivity following cold water intake in subjects with irritable bowel syndrome

Sex differences in dietary coping with gastrointestinal symptoms

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