Variation of Cold Agglutinin Levels

Abstract

Cold agglutinin levels were determined in 120 individuals ranging in age from 1 to 64 years using untreated and ficin-treated group O erythrocytes. The geometric mean titer for untreated cells was 5.7 +/- 1.1 SEM and for ficin-treated cells 18.7 +/- 1.1 SEM. The mean titers and scores for various blood groups were not significantly different. Titers and scores correlated significantly to total serum IgM concentration (p less than 0.001). Females had significantly higher cold agglutinin levels than males (p less than 0.001). A significant decrease of cold agglutinins occurred in the 26- to 64-year age group as compared to the 11- to 25-year age group (p less than 0.01). The data should contribute to a clearer understanding of the biological impact of cold agglutinins.

Cold Agglutinins and Cryoglobulins Associate With Clinical and Laboratory Parameters of Cold Urticaria

“…Our CA-positive patients were significantly more often female, which is consistent with previous reports ( 30 , 50 , 53 ). Furthermore, higher CA titers were linked to a female gender.…”

Red Blood Cell Cold Agglutinins and B Lymphocyte Cytotoxins in Breast Cancer Sera1

“…A positive correlation was previously shown between red blood cell cold agglutinin scores and serum IgM concentrations, both in normals [20] and in individuals with breast cancer [l]. The same relationship holds for this population of breast cancer sera, the correlation coefficient being 0.85 (p <0.01).…”

RBC alloantibody specificity and antigen potency in Olmsted County, Minnesota

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