RBC alloantibody specificity and antigen potency in Olmsted County, Minnesota

Winters, Jeffrey L.; Pineda, Alvaro A.; Gorden, Lemuel D.; Bryant, Sandra C.; Melton, L. Joseph; Vamvakas, Eleftherios C.; Moore, S. Breanndan

doi:10.1046/j.1537-2995.2001.41111413.x

Cited by 75 publications

(98 citation statements)

References 22 publications

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“…This finding is in agreement with other studies including Usman et al, (2011) andHiggins andSloan (2008). However, Winters et al (2001), Bauer et al (2007) and Verduin et al (2012), observed contrasting results. This disparity may be due to the difference in sample size and population.…”

Section: Our Findings Suggest Alloimmunisation Is Notsupporting

confidence: 93%

“…Factors such as number and frequency of transfusions (a measure of foreign antigen exposure), ethnic differences between recipient and donor (Gader et al, 2008;Shaz et al, 2008), immunogenicity of RBC antigens, recipient's sex (Murao and Viana, 2005), age (Winters et al, 2001), genetics (Noizat-Pirenne et al, 2006;Higgins and Sloan, 2008) and underlying disease (Bauer et al, 2007) have been found to influence alloimmunisation risk.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of red blood cell antibodies among transfused patients at Komfo Anokye teaching (Kath) hospital, Ghana

Antwi-Boateng¹,

Schonewille²,

Sackey³

et al. 2015

Jnl Sci Tech

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Red blood cell (RBC) alloimmunisation is a common problem in transfused patients because of the possibility of haemolytic reaction and limited availability of compatible blood. In highincome countries, pre-transfusion antibody screening is performed routinely. In Ghana, patients are transfused with ABO Rh 'D' compatible blood without screening for immune antibodies. We therefore studied the prevalence and specificities of RBC antibodies in transfused patients at Komfo Anokye Teaching hospital, Ghana. The study was cross-sectional, involving previously transfused patients who required another transfusion. Participants' basic data on demography and transfusion history were recorded. Blood samples were screened and subsequently typed for RBC antibodies using a column gel agglutination test. A total of 106 transfused patients, 52 male and 54 females were enrolled. The patients had previously received a median of 4 RBC units (range 1-14). Of these, ten patients (9.4%) had 11 RBC alloantibodies, whose specificities were 2 anti-K; 2 anti-C; one each of anti-D, -E, -M, and -S; and 3 were pan-reactive. The number of transfusion episodes was significantly associated with the rate of alloimmunisation (p=0.000). In conclusion the overall alloimmunisation rate in the study was 9.4% and this was significantly associated with increasing number of transfusion episodes. Antibodies were mainly directed against antigens in the Rhesus system and K antigen. We recommend that antibody screening be incorporated into routine pre-transfusion testing procedures in Ghana.

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Section: Our Findings Suggest Alloimmunisation Is Notsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Prevalence of red blood cell antibodies among transfused patients at Komfo Anokye teaching (Kath) hospital, Ghana

Antwi-Boateng¹,

Schonewille²,

Sackey³

et al. 2015

Jnl Sci Tech

View full text Add to dashboard Cite

show abstract

“…Combined data from 3 studies performed between 1974 and 1995 show comparable relative immunogenicity results for E-antigen, but c-antigen was 3 times (range, 1.2-4.2) less immunogenic, while Fy a -and Jk a -antigens were respectively 3 (range, 2.3-3.5) and 8 times (range, 5.7-12.7) more immunogenic than reported by Giblett [86][87][88] . Factors such as the sensitivity of antibody detection techniques, which has improved considerably over these study years, and the (patient) population under study may have had great impact on the occurrence of certain antibody specificities and therefore on its calculated immunogenicity.…”

Section: Immunogenicitymentioning

confidence: 84%

“…Observational studies in random patients, who most often receive incidental transfusions, and pregnant women, estimated the antibody prevalence between less than 1 to 3 percent [86][87][88][139][140][141][142][143][144][145][146][147] , but prospective systematic studies and studies in multitransfused patients reported on an up to over 70 percent alloimmunization incidence 148 .…”

Section: Red Blood Cell Antibodies In Diseasementioning

confidence: 99%

Red Blood Cell Alloimmunization after Blood Transfusion

Schonewille¹

2007

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“…Previous studies of the frequency of RBC alloimmunization have focused on Western societies [1][2][3][4] . Reports on the frequency of RBC alloimmunized patients or allogeneic blood donors are limited in populations from the Arabian Gulf region.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Red Blood Cell Alloantibody in Kuwaiti Population

et al. 2005

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Objective: The aim of this study was to analyze the alloimmunization against red blood cells (RBC) among Kuwaiti population. Materials and Methods: Retrospective analysis of RBC alloimmunization among 179,045 Kuwaiti patients, pregnant women, and allogeneic blood donors was conducted for the period of 1992–2001. The frequency of 24 alloantibody specificities from 1,278 alloimmunized Kuwaitis was estimated. Results: The prevalence of positive antibody screen in Kuwait was 0.49%.The five most frequently identified alloantibodies were anti-D (27.3%), anti-E (18.5%), anti-K (15.6%), anti-Lea (8.7%), and anti-Leb (6.6%). Frequency of alloimmunization was greater among Kuwaiti female than male patients (3.2 F to 1 M). Anti-D (p < 0.001), anti-E (p = 0.05), anti-K (p = 0.04) were also more frequently identified alloantibody among Kuwaiti females. Conclusion: The results show higher predominance of RBC alloimmunization in females than males. Anti-D, anti-E, and anti-K were the most common clinically significant alloantibodies identified in the Kuwaiti population and were also more frequent among Kuwaiti females.

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RBC alloantibody specificity and antigen potency in Olmsted County, Minnesota

Cited by 75 publications

References 22 publications

Prevalence of red blood cell antibodies among transfused patients at Komfo Anokye teaching (Kath) hospital, Ghana

Prevalence of red blood cell antibodies among transfused patients at Komfo Anokye teaching (Kath) hospital, Ghana

Red Blood Cell Alloimmunization after Blood Transfusion

Frequency of Red Blood Cell Alloantibody in Kuwaiti Population

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