Frequency of Red Blood Cell Alloantibody in Kuwaiti Population

Ameen, Reem; Al-Eyaadi, Ohood; Alshemmari, Salem; Chowdhury, Rafiqul I.; Al-Bashir, Abdulaziz

doi:10.1159/000085740

Cited by 30 publications

(27 citation statements)

References 20 publications

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“…Most of the studies done outside India report incidence of anti-K as high as 23% [17, 22, 23]. Low prevalence of anti-K in our study (4.5%) could be due to low frequency of Kell antigen in Indian population (1.97%) as compared to frequency of 8.8% in Caucasian population [24].…”

Section: Discussioncontrasting

confidence: 57%

Prevalence and Specificity of RBC Alloantibodies in Indian Patients Attending a Tertiary Care Hospital

Zaman

Chaurasia

Chatterjee

et al. 2014

Advances in Hematology

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Background. Red blood cell (RBC) alloimmunization results from genetic disparity of RBC antigens between donor and recipients. Data about alloimmunization rate in general patient population is scarce especially from resource limited countries. We undertook this study to determine prevalence and specificity of RBC alloantibodies in patients admitted in various clinical specialties at a tertiary care hospital in North India. Methods. Antibody screening was carried out in 11,235 patients on automated QWALYS 3 platform (Diagast, Loos, France). Antibody identification was carried out with an 11-cell identification panel (ID-Diapanel, Diamed GmbH, Switzerland). Results. The overall incidence of RBC alloimmunization in transfused patients was 1.4% (157/11235), with anti-E being the most common specificity (36.3%), followed by anti-D (16%), anti-c (6.4%), anti-c + E (6.4%), anti-C + D (5.1%), and anti-K (4.5%). The highest incidence of alloimmunization was observed in hematology/oncology patients (1.9%), whereas in other specialties the range was 0.7–1%. Conclusion. As alloimmunization complicates the transfusion outcomes, authors recommend pretransfusion antibody screening and issue of Rh and Kell matched blood to patients who warrant high transfusion requirements in future.

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Section: Discussioncontrasting

confidence: 57%

Prevalence and Specificity of RBC Alloantibodies in Indian Patients Attending a Tertiary Care Hospital

Zaman

Chaurasia

Chatterjee

et al. 2014

Advances in Hematology

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“…Antibody prevalence rates are known to depend on a number of population-specific factors, including underlying antigen genotype frequencies and histories of sensitization. For example, while samples in the U.S. [13], Canada [14], [15], England [5], the Netherlands [16], and Norway [17] report maternal anti-D prevalences that are similar to our estimates (between 8–23/10,000 births), a Kuwaiti sample reported a prevalence of 522/10,000, a rate that may be partially explained by the high local fertility rate [18]. Prevalence rates are also dependent on trends in clinical practice and screening technologies, so that observed changes over time are at least partly due to different routines and technologies used.…”

Section: Discussionsupporting

confidence: 71%

Constructing a Population-Based Research Database from Routine Maternal Screening Records: A Resource for Studying Alloimmunization in Pregnant Women

et al. 2011

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BackgroundAlthough screening for maternal red blood cell antibodies during pregnancy is a standard procedure, the prevalence and clinical consequences of non-anti-D immunization are poorly understood. The objective was to create a national database of maternal antibody screening results that can be linked with population health registers to create a research resource for investigating these issues.Study Design and MethodsEach birth in the Swedish Medical Birth Register was uniquely identified and linked to the text stored in routine maternal antibody screening records in the time window from 9 months prior to 2 weeks after the delivery date. These text records were subjected to a computerized search for specific antibodies using regular expressions. To illustrate the research potential of the resulting database, selected antibody prevalence rates are presented as tables and figures, and the complete data (from more than 60 specific antibodies) presented as online moving graphical displays.ResultsMore than one million (1,191,761) births with valid screening information from 1982–2002 constitute the study population. Computerized coverage of screening increased steadily over time and varied by region as electronic records were adopted. To ensure data quality, we restricted analysis to birth records in areas and years with a sustained coverage of at least 80%, representing 920,903 births from 572,626 mothers in 17 of the 24 counties in Sweden. During the study period, non-anti-D and anti-D antibodies occurred in 76.8/10,000 and 14.1/10,000 pregnancies respectively, with marked differences between specific antibodies over time.ConclusionThis work demonstrates the feasibility of creating a nationally representative research database from the routine maternal antibody screening records from an extended calendar period. By linkage with population registers of maternal and child health, such data are a valuable resource for addressing important clinical questions, such as the etiological significance of non-anti-D antibodies.

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“…RBC alloimmunization prevalence has been shown to be higher in females than in males in multiple studies, including those in blood donors . Pregnancy‐associated RBC alloimmunization has not previously been extensively studied, due in part to difficulties in uniformly obtaining and documenting lifetime pregnancy histories and in comparing these to lifetime transfusion histories.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors for RBC alloantibodies in blood donors in the Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III)

et al. 2018

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BACKGROUND: Little information exists on red blood cell (RBC) alloimmunization in healthy US blood donors, despite the potential significance for donors themselves, blood recipients, and the blood center.R ed blood cell (RBC) alloantibodies are appreciated to be clinically significant in the transfusion setting, with substantial blood bank resources dedicated to completing RBC antibody screens and to identifying RBC antibodies in patients. 1 Though most antibodies do not lead to adverse transfusion outcomes, they may substantially delay the provision of compatible RBC units, impacting patient care. On occasion, acute and delayed hemolytic transfusion reactions occur 2,3 despite ABBREVIATIONS: CI = confidence interval; NHLBI = National Heart, Lung, and Blood Institute; OR = odds ratio; REDS-III = Recipient Epidemiology and Donor Evaluation Study-III.From the

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Frequency of Red Blood Cell Alloantibody in Kuwaiti Population

Cited by 30 publications

References 20 publications

Prevalence and Specificity of RBC Alloantibodies in Indian Patients Attending a Tertiary Care Hospital

Prevalence and Specificity of RBC Alloantibodies in Indian Patients Attending a Tertiary Care Hospital

Constructing a Population-Based Research Database from Routine Maternal Screening Records: A Resource for Studying Alloimmunization in Pregnant Women

Prevalence and risk factors for RBC alloantibodies in blood donors in the Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III)

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