Variation in Trace Metal Concentrations along Single Hairs as Measured by Proton-induced X-ray Emission Photometry

Valković, V.; Miljanić, Đ.; Wheeler, R.M.; Liebert, R.B.; Zabel, T.H.; Phillips, G.C.

doi:10.1038/243543a0

Cited by 39 publications

(11 citation statements)

References 11 publications

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“…S1b † for comparable data at lower accuracy from PIXE). Nuclear microprobes have a long history of elemental mapping of biological tissues and cells on a micron scale [12][13][14] with high sensitivity and accurate quantication available when PIXE and EBS are used self-consistently. 15 This work investigates the uptake of GNPs by RT112 cancer cells, where the GNPs were coated with Fetal Bovine Serum (FBS) or with a transactivator of transcription (TAT) peptide before incubation with the cells.…”

mentioning

confidence: 99%

Measuring and modelling cell-to-cell variation in uptake of gold nanoparticles

Jeynes

Merchant

et al. 2013

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The cell-to-cell variation of gold nanoparticle (GNP) uptake is important for therapeutic applications. We directly counted the GNPs in hundreds of individual cells, and showed that the large variation from cell-to-cell could be directly modelled by assuming log-normal distributions of both cell mass and GNP rate of uptake. This was true for GNPs non-specifically bound to fetal bovine serum or conjugated to a cell penetrating peptide. Within a population of cells, GNP content varied naturally by a factor greater than 10 between individual cells.

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confidence: 99%

Measuring and modelling cell-to-cell variation in uptake of gold nanoparticles

Jeynes

Merchant

et al. 2013

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“…Proton-induced X-ray emission photometry (PIXE) 5 and X-ray fluorescence (XRF) 6 have been used to directly sample along the length of single hair strands. These techniques are capable of spatial resolutions of millimeters of hair.…”

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confidence: 99%

Direct detection of mercury in single human hair strands by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

Legrand

Lam

Jensen-Fontaine

et al. 2004

J. Anal. At. Spectrom.

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“…On the other hand, because of its slower turnover, the zinc content of the hair re flects total body zinc more accurately [13,14], In fact, zinc content of the hair in pa tients with homozygous /¿-thalassemia proved to be low in our determination, as it was for erythrocytes and plasma.…”

Section: Discussionmentioning

confidence: 86%

Zinc Levels of Plasma, Erythrocyte, Hair and Urine in Homozygote Beta-Thalassemia

Doğru¹,

Arcasoy²,

Çavdar³

1979

Acta Haematol

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The zinc levels of plasma, erythrocytes, hair and urine were determined by atomic absorption spectrophotometer technique in 20 homozygous β-thalassemic and 20 control children. Plasma, erythrocyte and hair zinc levels in the diseased children were found to be much lower than those of controls. The difference was statistically highly significant. Along with other factors, zinc deficiency was wrought to have an important role in the retardation of growth and sexual development seen in the patients with homozygous β-thalassemia. The increased urinary zinc excretion suggests that the factor responsible for zinc deficiency might be the loss of the element through the kidneys.

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Variation in Trace Metal Concentrations along Single Hairs as Measured by Proton-induced X-ray Emission Photometry

Cited by 39 publications

References 11 publications

Measuring and modelling cell-to-cell variation in uptake of gold nanoparticles

Measuring and modelling cell-to-cell variation in uptake of gold nanoparticles

Direct detection of mercury in single human hair strands by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

Zinc Levels of Plasma, Erythrocyte, Hair and Urine in Homozygote Beta-Thalassemia

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