Variation in the composition of gingival inflammatory cell infiltrates

Johannessen, A. C.; Nllsen, R.; Kristoffersen, T.; Knudsen, G. E.

doi:10.1111/j.1365-2710.1992.tb00780.x

Cited by 7 publications

(14 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, these ANAE negative cells also include a few polymorphonuclear cells, plasma cells and possibly mast cells. Our observations that plasma ceils constituted a very small proportion of the inflammatory infiltrate in the inflamed gingiva of the children studied, are also in accordance with the observations of Seymour et al, (1981Seymour et al, ( , 1982 and Walsh et al, (1987), Although direct comparisons can not be made, we got the impression that the variability from section to section and from biopsy to biopsy was less pronounced in children than in adult CIPD (Johannessen et al, , 1990, Further studies of gingival inflammatory infiltrates in children are called for. Such studies should aim to elucidate both their cellular composition with more specific markers and their variability from individual to individual and from section to section in the same specimen.…”

Section: Discussionsupporting

confidence: 78%

The composition of gingival inflammatory cell infiltrates in children studied by enzyme histochemistry

et al. 1992

View full text Add to dashboard Cite

Alcoforado GAP, Kristoffersen T. Johannessen AC and Nilsen R. The composition of gingival irtflammatory eell infiltrates in children studied by enzyme histochemistry. J Clin Periodoniol 1990; 17: 335-340. Abstract. Gingival biopsies were obtained from 23 children, aged 5-11 years (8.6+ 1.8 years). Specimens were taken from areas of the gingiva adjacent to the teeth which were to be extracted because of caries or its sequelae and which clinically had a gingival index score of at least 1. Staining for a-naphthyl acetate esterase with unspecific esterase at pH 5.8 (ANAE) permitted identification of T lymphocytes, monocytes/macrophages. plasma cells and non-reactive (ANAEnegative) cells. Cells which tentatively were identified as "natural killer" (NK) cells were also observed. Differential cell counting was performed for 10 specimens, selected on the basis of the presence of a well-defined inflammalory infiltrate, clear morphology throughout and good ANAE staining. Cell counts confirmed earlier studies showing that lymphocytes predominate in the inflammatory infiltrates in childrens" gingivitis. T lymphocytas dominated particularly in the periphery of the most densely infiltrated areas. Relatively few plasma cells were seen. It was concluded that T lymphocytes dominate in the inflaimnatory infiltrate in childrens' gingivitis.

show abstract

Section: Discussionsupporting

confidence: 78%

The composition of gingival inflammatory cell infiltrates in children studied by enzyme histochemistry

et al. 1992

View full text Add to dashboard Cite

show abstract

“…The variation reported could be attributed to the uneven distribution of T-lymphocytes and macrophages in the gingival tissues of aggressive periodontitis lesions. [25] Some specimens may have been harvested inadvertently from gingival tissue areas with little or no HCMV and HSV-1 present, and missed gingival domains with significant occurrence of these viruses. Prevalence of herpesvirus carriage varies by age, country, and region and population subgroup.…”

Section: International Journal Of Dental Researchmentioning

confidence: 99%

Role of herpes simplex-1, epstein barr and human cytomegalo viruses in aggressive periodontitis

Dani¹,

Dwarakanath

Alampalli

et al. 2013

International Journal of Dental Research

View full text Add to dashboard Cite

Objectives: Aggressive periodontitis is characterized rapid and severe destruction of the tooth supporting tissues with a complex and unclear etiopathogenesis. The present study was designed to identify the role of herpesviruses in pathogenesis of aggressive periodontitis. Material and methods: Study included 15 subjects diagnosed with aggressive periodontitis (group A) and 15 periodontally healthy subjects (group B). Subgingival plaque was collected from the deepest periodontal pocket and gingival tissue biopsy from the adjacent interdental papilla. Results analyzed by polymerase chain reaction. Results: EBV detected in 67% plaque and 73% tissue samples in group A, 7% plaque and none in the tissue samples in group B. HCMV identified in 53% plaque and 20% of tissue samples in group A, 20% plaque and 7% tissue samples in group B. HSV-1 found in 47% plaque and 13% tissue samples in group A, 13% plaque and 47% tissue samples in group B. Conclusion: An increased prevalence of EBV, HCMV and HSV-1 in group A in comparison to healthy controls was observed. Only EBV showed significant difference between both groups. Despite similarity in pathogenic traits between herpesvirus diseases and Periodontitis, delineating the exact role that viruses play in the etiopathogenesis of aggressive periodontitis is difficult.

show abstract

“…Although it has been reported that there is a relationship between local immune response and gingivitis (Okada et al, 1984;Jully et al, 1986;Stoufi et al, 1987;Taubman et al, 1984;Johannessen et al, 1989), no study indicating the effects of sinistrality and dexterity on local immune response in the patients with gingivitis was encountered. The purpose of this study was to determine whether there was any change in T-lymphocyte subsets in the sinistrality and dexterity with gingivitis.…”

mentioning

confidence: 80%

Flow-Cytometric Analysis of T-Lymphocyte Subsets in Sinistral and Dextral Patients With Gingivitis

Orbak

Çanakçı

Ercıyas

et al. 2003

International Journal of Neuroscience

View full text Add to dashboard Cite

The aim of this study was to determine whether there was any change in T-lymphocyte subsets in sinistral and dextral patients with gingivitis. The study was carried out on 36 patients (16 males and 20 females) with gingivitis. The age of the patients ranged from 16 to 25 (mean age = 18.50 +/- 3.85). Patients were divided into two equal groups according to their right or left hand use. Being right- or left-handed was determined with Edinburgh Handedness Inventory (Oldfield). At the beginning of the study, gingival index (GI-Löe-Silness) and plaque index (PI-Silness-Löe) scores were recorded in order to assess the gingival tissue health in patients. At the same time, the biopsy samples were taken from the gingival pocket wall tissues at sites of gingivitis. Then, CD4+ and CD8+ lymphocyte and CD4/CD8 ratio values were determined using flow-cytometry in the biopsy samples. The two groups were compared by using Student's t-test. The normal value in peripheral blood of CD4+ lymphocyte and that of CD8+ lymphocyte are 25-29% and 19-48%, respectively. According to flow cytometry findings, in both sinistrality and dexterity with gingivitis, CD+ and CD8+ lymphocyte values were under the normal value while the CD4/CD8 rate was within normal distribution interval. CD4+ lymphocyte values observed in the sinistral patients were found to be lower than those in the dextral patients. The difference between the CD8+ lymphocyte values in left-handed patients and that obtained in right-handed patients was not found to be statistically significant while the difference between the CD4+ lymphocyte values in left-handed patients and that obtained in right-handed patients was found to be statistically significant (p < .05). In addition, the difference between the CD4/CD8 rate obtained in left-handed patients and that obtained in right-handed patients was found to be statistically very significant (p < .001). Consequently, these findings suggested CD4+ lymphocyte value and CD4/CD8 rate was lower in sinistrality. Sinistrality and dexterity may play an important role in local immune response.

show abstract

Variation in the composition of gingival inflammatory cell infiltrates

Cited by 7 publications

References 36 publications

The composition of gingival inflammatory cell infiltrates in children studied by enzyme histochemistry

The composition of gingival inflammatory cell infiltrates in children studied by enzyme histochemistry

Role of herpes simplex-1, epstein barr and human cytomegalo viruses in aggressive periodontitis

Flow-Cytometric Analysis of T-Lymphocyte Subsets in Sinistral and Dextral Patients With Gingivitis

Contact Info

Product

Resources

About