Variation in Plasma Calcium with Induced Changes in Plasma Specific Gravity, Total Protein, and Albumin

Berry, E. M.; Gupta, M. M.; Turner, Steve; Burns, R. R.

doi:10.1136/bmj.4.5893.640

Cited by 141 publications

(48 citation statements)

References 10 publications

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“…It has been reported that venous occlusion influences the total calcium concentration of serum (Berry et al, 1973). This is clearly seen in Fig.…”

Section: Blood-samplingsupporting

confidence: 57%

“…In this situation the total calcium concentration by itself may be clinically misleading unless the serum protein concentration is taken into account. A number of corrections are available which claim to adjust plasma calcium for changes in protein concentration, though there is some controversy as to which correction factor should be applied (Dent, 1962;Parfitt, 1969;Berry et al, 1973;Payne et al, 1973). Clearly measuring ionised calcium instead of total calcium overcomes this problem.…”

Section: Blood-samplingmentioning

confidence: 99%

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Measurement of Ionised Calcium in Body Fluids—A Review

Robertson

1976

Ann Clin Biochem

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This paper reviews the techniques available to the clinical biochemist for measuring ionised calcium concentrations in biological fluids with particular reference to serum. At present ionised calcium may be measured colorimetrically, using tetramethyl murexide, or potentiometrically, using a calcium ion-selective electrode. These techniques compare favourably in terms of precision with existing methods for measuring total calcium. Advantages of measuring ionised calcium in preference to total calcium are ( a) that there is no effect of venous occlusion or change of posture on the ionised fraction of the effect on total calcium, ( b) that ionised calcium is the physiologically active form of the element, and ( c) that the ionised calcium concentration is a more reliable indicator of the calcium status of patients in certain clinical conditions. The main problem in the measurement of ionised calcium is the marked dependence of the ionised fraction on the pH of the sample. Extreme care must be taken to avoid loss of CO2 or build-up of acid during the handling of the blood sample.

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“…It has been reported that venous occlusion influences the total calcium concentration of serum (Berry et al, 1973). This is clearly seen in Fig.…”

Section: Blood-samplingsupporting

confidence: 57%

Section: Blood-samplingmentioning

confidence: 99%

Measurement of Ionised Calcium in Body Fluids—A Review

Robertson

1976

Ann Clin Biochem

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“…Serum total calcium (TCa), phosphate, creatinine, albumin, and total alkaline phosphatase were measured by standard automated methods in an ADVIA 2400 Chemistry System autoanalyser (Siemens, Germany). TCa measurements were corrected for albumin concentration (cCa) following a previously published formula (17 intact PTH, the detection limit was 6 pg/ml, with a normal range of 15-65 pg/ml.…”

Section: Biochemical Testsmentioning

confidence: 99%

Serum 25-hydroxyvitamin D, parathyroid hormone, calcium intake, and bone mineral density in Spanish adults

et al. 2015

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1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 3 Mini AbstractVitamin D insufficiency was very common among Spanish community-dwelling adult subjects. A threshold of serum 25(OH)D around 30 ng/ml would be necessary for the prevention of secondary hyperparathyroidism and hip bone loss in our population, regardless of the dairy calcium ingestion.

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“…We performed multivariate binary logistic regression analysis to determine the influence of serum lipid levels and prevalent vertebral and non-vertebral fractures. analyses centration (cCa) according to a previously published formula [29]. Glomerular filtration rate was calculated using the four-variable MDRD formula and expressed in mL/min/1.73 m 2 [30].…”

Section: Discussionmentioning

confidence: 99%

Serum Lipids and Bone Metabolism in Spanish Men: The Camargo Cohort Study

et al. 2010

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Abstract. There is growing evidence of a link between lipid and bone metabolism, although data on this association in European men are scarce. This cross-sectional study from a community-based prospective cohort aims to explore the association of serum lipids with different aspects of bone metabolism in spanish men. Demographic and anthropometric measurements, biochemical parameters including serum lipids, bone remodelling markers and calciotropic hormones, bone mineral density (BMD) assessed by dual X-ray absorptiometry and heel quantitative ultrasound, and prevalent vertebral and non-vertebral fractures, were evaluated in 289 men. Calciotropic hormones or bone markers were not associated with serum lipids. serum total (TC) and LDL cholesterol, as well as LDL/HDL ratio were positively correlated to BMD at lumbar spine and hip. No significant correlation was noted for triglycerides or HDL. We observed a positive association between triglycerides, LDL/HDL ratio and Bua, and between TC/HDL ratio and both, Qui and Bua. BMD at the femoral neck and total hip was significantly higher in men with hypercholesterolemia after controlling for all the covariates (p=0.007). We did not observe any association between serum lipids and prevalent vertebral fractures. However, we found that TC (p=0.03) and LDL (p=0.04) were lower in subjects with non-vertebral fractures. in conclusion, we have found that a more unfavorable lipid profile (mainly higher LDL-C levels) is associated with higher BMD at lumbar spine and hip in spanish men. Moreover, we did not observe any association between hypercholesterolemia and prevalent vertebral fractures, but we found lower serum TC and LDL-C levels in men with prevalent non-vertebral fractures.

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Variation in Plasma Calcium with Induced Changes in Plasma Specific Gravity, Total Protein, and Albumin

Cited by 141 publications

References 10 publications

Measurement of Ionised Calcium in Body Fluids—A Review

Measurement of Ionised Calcium in Body Fluids—A Review

Serum 25-hydroxyvitamin D, parathyroid hormone, calcium intake, and bone mineral density in Spanish adults

Serum Lipids and Bone Metabolism in Spanish Men: The Camargo Cohort Study

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