Serum Lipids and Bone Metabolism in Spanish Men: The Camargo Cohort Study

Abstract

Abstract. There is growing evidence of a link between lipid and bone metabolism, although data on this association in European men are scarce. This cross-sectional study from a community-based prospective cohort aims to explore the association of serum lipids with different aspects of bone metabolism in spanish men. Demographic and anthropometric measurements, biochemical parameters including serum lipids, bone remodelling markers and calciotropic hormones, bone mineral density (BMD) assessed by dual X-ray absorptiometry and heel quantitative ultrasound, and prevalent vertebral and non-vertebral fractures, were evaluated in 289 men. Calciotropic hormones or bone markers were not associated with serum lipids. serum total (TC) and LDL cholesterol, as well as LDL/HDL ratio were positively correlated to BMD at lumbar spine and hip. No significant correlation was noted for triglycerides or HDL. We observed a positive association between triglycerides, LDL/HDL ratio and Bua, and between TC/HDL ratio and both, Qui and Bua. BMD at the femoral neck and total hip was significantly higher in men with hypercholesterolemia after controlling for all the covariates (p=0.007). We did not observe any association between serum lipids and prevalent vertebral fractures. However, we found that TC (p=0.03) and LDL (p=0.04) were lower in subjects with non-vertebral fractures. in conclusion, we have found that a more unfavorable lipid profile (mainly higher LDL-C levels) is associated with higher BMD at lumbar spine and hip in spanish men. Moreover, we did not observe any association between hypercholesterolemia and prevalent vertebral fractures, but we found lower serum TC and LDL-C levels in men with prevalent non-vertebral fractures.

Metabolic Syndrome and Bone Mineral Density in Post Menopausal Women: Is There Any Link?

“…Data on the link between other components of MetSBlood pressure and serum concentrations of glucose and HDL cholesterol-and BMD are conflicting. Similarly to our data, BMD was not associated with fasting glucose [5,[27][28][29][30], with HDLc [5,7,27,29], and with systolic blood pressure [27][28][29].…”

“…Therefore, it is feasible that the resultant low-grade inflammation, which is known to be involved in the pathophysiologic mechanisms underlying osteoporosis [10], may lead to bone loss despite the protective effects of general obesity. In other studies, abdominal obesity was found to be a protective factor on BMD at the lumbar spine [5], the total hip [5,27], and the femoral neck [5]. Currently, the mechanism of the effect of fat on bone is not clear.…”

“…The literature data about this association is inconclusive. Higher [4][5][6] and lower [7, 27- (Table 4). Significant predictive factors for the BMD were age and exercise in the lumbar spine, and age and BMI in the total hip.…”

“…A study conducted in the USA has found, after adjusting for age, gender, and other covariates, that femur neck BMD was higher in subjects with MetS [4]. In the Camargo Cohort Study, women with MetS had higher age-adjusted BMD at the total hip, femur neck, and lumbar spine than MetS-free women [5]. On the other hand, men with MetS had a lower BMD at the femur neck in the Rancho Bernardo Study after adjusting for Body Mass Index (BMI) [6].…”

Adverse effects of coexistence of sarcopenia and metabolic syndrome in Japanese women

“…38 Hernandez et al 38 reported that despite the greater bone mass and lower bone turnover, fracture prevalence was not reduced, suggesting poorer bone quality and/or a higher tendency to fall. On the other hand, the mean vertebral BMD was significantly lower in subjects with MetS after adjustment for age, weight and height among 2475 Korean women.…”