Variation and expression of HLA-DPB1 gene in HBV infection

Ou, Guomin; Liu, Xiao; Xu, Haixia; Ji, Xin; Liu, Xiaojuan; Wang, Jue

doi:10.1007/s00251-021-01213-w

Cited by 10 publications

(7 citation statements)

References 34 publications

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“…HLA-DPA1*01:03 and HLA-DPB1*13:01 were previously shown to be significantly associated with chronic hepatitis B in the Thai population ( Nishida et al, 2014 ) with protective and susceptibility effects, respectively. The HLA-DQB1*06:09 and HLA-DPA1/DPB1 alleles which we reported here, have been detected to be associated with chronic hepatitis B with similar tendencies in previous reports in different ethnic groups ( Cho et al, 2008 ; Kamatani et al, 2009 ; Hu et al, 2013 ; Nishida et al, 2014 , 2015 , 2016 ; Li Y. et al, 2016 ; Zhu et al, 2016 ; Ou et al, 2019 , 2021 ; Huang et al, 2020 ). However, HLA-DQB1*03:03 is associated with both an increased ( Mbarek et al, 2011 ) and decreased risk of chronic hepatitis B ( Xi-Lin et al, 2006 ; Zhang et al, 2015 ; Huang et al, 2016 ).…”

Section: Discussionsupporting

confidence: 91%

Genome-Wide Association Study for Chronic Hepatitis B Infection in the Thai Population

et al. 2022

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To identify novel host genetic variants that predispose to hepatitis B virus (HBV) persistence, we performed the first genome-wide association study in the Thai population involving 318 cases of chronic hepatitis B and 309 healthy controls after quality control measures. We detected the genome-wide significant association of the HLA class II region (HLA-DPA1/DPB1, rs7770370, p-value = 7.71 × 10−10, OR = 0.49) with HBV chronicity. Subsequent HLA allele imputation revealed HLA-DPA1*01:03 (Pc = 1.21 × 10−6, OR = 0.53), HLA-DPB1*02:01 (Pc = 2.17 × 10−3, OR = 0.50), and HLA-DQB1*06:09 (Pc = 2.17 × 10−2, OR = 0.07) as protective alleles, and HLA-DPA1*02:02 (Pc = 6.32 × 10−5, OR = 1.63), HLA-DPB1*05:01 (Pc = 1.13 × 10−4, OR = 1.72), HLA-DPB1*13:01 (Pc = 4.68 × 10−2, OR = 1.60), and HLA-DQB1*03:03 (Pc = 1.11 × 10−3, OR = 1.84) as risk alleles for HBV persistence. We also detected suggestive associations in the PLSCR1 (rs35766154), PDLIM5 (rs62321986), SGPL1 (rs144998273), and MGST1 (rs1828682) loci. Among single-nucleotide polymorphisms in the PLSCR1 locus, rs1061307 was identified as the primary functional variant by in silico/in vitro functional analysis. In addition to replicating the association of the HLA class II region, we detected novel candidate loci that provide new insights into the pathophysiology of chronic hepatitis B.

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Section: Discussionsupporting

confidence: 91%

Genome-Wide Association Study for Chronic Hepatitis B Infection in the Thai Population

et al. 2022

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“…The role of the HLA-DPB1 has gained greater relevance due to its association with various pathologies, including cancer ( 59 ), autoimmune diseases, such as rheumatoid arthritis ( 60 ), responses to viral infection ( 61 ), and vaccines ( 62 , 63 ). Regarding stem cell transplants, there is still controversy about the inclusion of the HLA-DPB1 locus in the search algorithms for 12/12 histocompatibility ( 64 ) due to the increasing number of reports indicating that a mismatch in this locus increases the risk of developing GVHD ( 65 ).…”

Section: Discussionmentioning

confidence: 99%

Distributions of the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 alleles and haplotype frequencies of 1763 stem cell donors in the Colombian Bone Marrow Registry typed by next-generation sequencing

Hernández¹,

Páez-Gutiérrez²,

Ardón³

et al. 2023

Front. Immunol.

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The HLA compatibility continues to be the main limitation when finding compatible donors, especially if an identical match is not found within the patient’s family group. The creation of bone marrow registries allowed a therapeutic option by identifying 10/10 compatible unrelated donors (URD). However, the availability and frequency of haplotypes and HLA alleles are different among ethnic groups and geographical areas, increasing the difficulty of finding identical matches in international registries. In this study, the HLA-A, -B, -C, -DRB1, and -DQB1 loci of 1763 donors registered in the Colombian Bone Marrow Registry were typed by next-generation sequencing. A total of 52 HLA-A, 111 HLA-B, 41 HLA-C, 47 HLA-DRB1, and 20 HLA-DQB1 alleles were identified. The 3 most frequent alleles for each loci were A*24:02g (20,8%), A*02:01g (16,1%), A*01:01g (7.06%); B*35:43g (7.69%), B*40:02g (7.18%), B*44:03g (6.07%); C*04:01g (15.40%), C*01:02g (10.49%), C*07:02g (10.44%); DRB1*04:07g (11.03%), DRB1*07:01g (9.78%), DRB1*08:02g (6.72%); DQB1*03:02g (20.96%), DQB1*03:01g (17.78%) and DQB1*02:01g (16.05%). A total of 497 HLA-A-C-B-DRB1-DQB1 haplotypes were observed with a frequency greater than or equal to 0.05% (> 0.05%); the haplotypes with the highest frequency were A*24:02g~B*35:43g~C*01:02g~DQB1*03:02g~DRB1*04:07g (3.34%), A*29:02g~B*44:03g~C*16:01g~DQB1*02:01g~DRB1*07:01g (2.04%), and A*01:01g~B*08:01g~C*07:01g~DQB1*02:01g~DRB1*03:01g (1.83%). This data will allow the new Colombian Bone Marrow Donor Registry to assess the genetic heterogeneity of the Colombian population and serve as a tool of interest for future searches of unrelated donors in the country.

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“…HLA-DPB1 significantly impacts the likelihood of CHB infection, and CHB infection is linked to a reduction in HLA-DPB1 expression. The expression of HLA-DPB1 is essential in the control of CHB [ 31 ]. The development of therapies that increase the expression of HLA-DPB1 may prove helpful in the treatment of CHB.…”

Section: Discussionmentioning

confidence: 99%