Variants of PCSK9 Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project

Zamarrón-Licona, Erasmo; Rodríguez-Pérez, José Manuel; Posadas-Sánchez, Rosalinda; Vargas‐Alarcón, Gilberto; Baños-González, Manuel Alfonso; Borgonio-Cuadra, Verónica Marusa; Pérez-Hernández, Nonanzit

doi:10.3390/diagnostics11050774

Cited by 8 publications

(11 citation statements)

References 63 publications

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“…Our results are consistent with a recent study by Zamarrón-Licona et al in healthy individuals and subclinical atherosclerosis patients. No significant association between total plasma cholesterol and triglyceride, with PCSK9 rs615563, was found in this study, and interestingly, the rs615563 polymorphism in the control group was associated with a decreased risk of hypertriglyceridemia [ 32 ].…”

Section: Main Textmentioning

confidence: 90%

Association between the rs615563 variant of PCSK9 gene and circulating lipids and Type 2 diabetes

et al. 2021

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Objective Many different genetic variants of proprotein convertase subtilisin kexin 9 (PCSK9) are related to the serum levels of cholesterol and LDL cholesterol (LDL-C). The rs615563 variant of PCSK9 (a gain-of-function mutation) is associated with increased triglycerides and cholesterol levels, but its association with the incidence of diabetes is not well defined. This study aimed to investigate the relationship between the PCSK9 rs615563 variant with the incidence of type 2 diabetes. The data reported in this study are based on subsamples from a 5-year (2009–2014) cohort study of the adult population (590 subjects) aged 20 years and older. The rs615563 polymorphism was genotyped using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) analysis. Results The distribution of PCSK9 rs615563 genotypes was not significantly different between the diabetic and non-diabetic individuals. The incidence of diabetes after five-years of follow-up was not different between the genotypes. Our findings also showed no significant relationship between this polymorphism and serum lipid parameters. The data extracted from our cohort study do not support the findings that the gain-of-function mutations of PCSK9 predispose to the incidence of type 2 diabetes.

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Section: Main Textmentioning

confidence: 90%

Association between the rs615563 variant of PCSK9 gene and circulating lipids and Type 2 diabetes

et al. 2021

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“…We adjusted all of our analyses for the key confounders such as sex, age, education, smoking status, diabetes mellitus and physical activity to attenuate the impact of selection bias. Previous studies have demonstrated that some genetic polymorphisms are associated with a higher risk of pCAD in the Mexican-Mestizo population [ 28 , 75 ]. However, we did not evaluate the interaction between genetic susceptibility and air pollution exposure on pCAD risk.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Exposure to Ozone and Fine Particulate Matter and Risk of Premature Coronary Artery Disease: Results from Genetics of Atherosclerotic Disease Mexican Study

Posadas-Sánchez

Vargas‐Alarcón

Texcalac-Sangrador

et al. 2022

Biology

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(1) Background: Epidemiological studies have identified associations between fine particulate matter (PM2.5) and ozone exposure with cardiovascular disease; however, studies linking ambient air pollution and premature coronary artery disease (pCAD) in Latin America are non-existing. (2) Methods: Our study was a case–control analysis nested in the Genetics of Atherosclerotic Disease (GEA) Mexican study. We included 1615 participants (869 controls and 746 patients with pCAD), recruited at the Instituto Nacional de Cardiología Ignacio Chávez from June 2008 to January 2013. We defined pCAD as history of myocardial infarction, angioplasty, revascularization surgery or coronary stenosis > 50% diagnosed before age 55 in men and age 65 in women. Controls were healthy individuals without personal or family history of pCAD and with coronary artery calcification equal to zero. Hourly measurements of ozone and PM2.5 from the Atmospheric Monitoring System in Mexico City (SIMAT in Spanish; Sistema de Monitero Atmosférico de la Ciudad de México) were used to calculate annual exposure to ozone and PM2.5 in the study participants. (3) Results: Each ppb increase in ozone at 1-year, 2-year, 3-year and 5-year averages was significantly associated with increased odds (OR = 1.10; 95% CI: 1.03–1.18; OR = 1.17; 95% CI: 1.05–1.30; OR = 1.18; 95% CI: 1.05–1.33, and OR = 1.13; 95% CI: 1.04–1.23, respectively) of pCAD. We observed higher risk of pCAD for each 5 µg/m3 increase only for the 5-year average of PM2.5 exposure (OR = 2.75; 95% CI: 1.47–5.16), compared to controls. (4) Conclusions: Ozone exposure at different time points and PM2.5 exposure at 5 years were associated with increased odds of pCAD. Our results highlight the importance of reducing long-term exposure to ambient air pollution levels to reduce the burden of cardiovascular disease in Mexico City and other metropolitan areas.

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“…High alkaline phosphatase concentrations were defined when values were ≥75th percentile (83.00 IU/L in men and 90.25 IU/L in women). Percentile values of adiponectin and alkaline phosphatase were acquired from a representative subsample of the GEA participants [ 34 , 35 ].…”

Section: Methodsmentioning

confidence: 99%

Osteopontin Gene Polymorphisms Are Associated with Cardiovascular Risk Factors in Patients with Premature Coronary Artery Disease

et al. 2021

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Osteopontin (OPN) is considered a clinical predictor of cardiovascular disease. We aimed to evaluate the association of the OPN gene polymorphisms rs2728127 and rs11730582 with the development of premature coronary artery disease (pCAD), cardiovascular risk factors, and cardiometabolic parameters. We evaluated 1142 patients with pCAD and 1073 controls. Both polymorphisms were determined by Taqman assays. Similar allele and genotype frequencies were observed in both groups; additionally, an association of these polymorphisms with CAD and cardiometabolic parameters was observed in both groups. In patients with pCAD, the rs11730582 was associated with a high risk of hypoadiponectinemia (OR = 1.300, P additive = 0.003), low risk of hypertension (OR = 0.709, P codominant 1 = 0.030), and low risk of having high non-HDL cholesterol (OR = 0.637, P additive = 0.038). In the control group, the rs2728127 was associated with a low risk of fatty liver (OR = 0.766, P additive = 0.038); while the rs11730582 was associated with a low risk of hypoadiponectinemia (OR = 0.728, P dominant = 0.022), and risk of having elevated apolipoprotein B (OR = 1.400, P dominant = 0.031). Our results suggest that in Mexican individuals, the rs11730582 and rs2728127 OPN gene polymorphisms are associated with some abnormal metabolic variables in patients with pCAD and controls.

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Variants of PCSK9 Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project

Cited by 8 publications

References 63 publications

Association between the rs615563 variant of PCSK9 gene and circulating lipids and Type 2 diabetes

Association between the rs615563 variant of PCSK9 gene and circulating lipids and Type 2 diabetes

Long-Term Exposure to Ozone and Fine Particulate Matter and Risk of Premature Coronary Artery Disease: Results from Genetics of Atherosclerotic Disease Mexican Study

Osteopontin Gene Polymorphisms Are Associated with Cardiovascular Risk Factors in Patients with Premature Coronary Artery Disease

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