Variant translocation in Burkitt's lymphoma: 8;22 translocation in a french patient with an Epstein-Barr virus-associated tumor

Fraisse, J; Lenoir, Gilbert; Vasselon, C; Jaubert, J.; Brizard, C.P.

doi:10.1016/0165-4608(81)90070-4

Cited by 13 publications

(5 citation statements)

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“…It is found in both endemic and non-endemic BL and is regarded as the best marker of Burkitt cells. This translocation has been reported only in one Arab BL case living in Israel (Prokocimer et al, 1980), but our personal experience confirms its occurrence in North African Arab yoshi et al, 1979;Van den Berghe et al, 1979;Bornkamm et al, 1980); and a second variant translocation, t(8;22) (q23;q12), was recently reported in EBV-positive and -negative BL cases in France (Berger et al, 1979;Tamer et al, 1980;Bertrand et al, 1981;Fraisse et al, 1981). The t(2;8) variant translocation was reported for the first time in Africa by Bernheim in BL cell lines established from endemic African cases (Bernheim et al, 1980).…”

Section: Dlscussionsupporting

confidence: 79%

“…Although most such cases are not EBV-associated (Epstein and Achong, 1979), the t(8;14) has been found in the majority of tumours studied (Sandberg, 1980). However, the 8;14 translocation is not the only rearrangement described: the recent reports of two types of variant translocations [t(2;8) and t(8;22)] indicate that the chromosome 8 rearrangement with a break-point in 8q23 or 8q24 (depending on the type of banding used) is the only constant cytogenetic feature characteristic of BL (Berger et al, 1979;Miyoshi et al, 1979;Van den Berghe et al, 1979;Bornkamm et al, 1980;Tanzer et al, 1980;Bertrand et al, 1981;Fraisse et al, 1981).…”

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confidence: 99%

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EBV‐positive Burkitt's lymphoma from algeria, with a three‐way rearrangement involving chromosomes 2, 8 and 9

Philip

Lenoir

Fraisse³

et al. 1981

Intl Journal of Cancer

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Burkitt's lymphoma was diagnosed in male Algerian child presenting with abdominal and jaw tumours. Viral studies revealed that this non-endemic case was associated with the Epstein-Barr virus. Cytogenetic examination of tumour cells showed a complex three-way rearrangement involving chromosomes 2, 8 and 9. Our report indicates that, in Burkitt's lymphoma, not only simple but also complex translocation involving chromosome 8 may arise. This finding in a North African case emphasizes the need for more detailed study of the clinical, virological and cytogenetic features of Burkitt's lymphoma throughout the world.

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Section: Dlscussionsupporting

confidence: 79%

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confidence: 99%

EBV‐positive Burkitt's lymphoma from algeria, with a three‐way rearrangement involving chromosomes 2, 8 and 9

Philip

Lenoir

Fraisse³

et al. 1981

Intl Journal of Cancer

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“…Variation in chromosomes X and 1 in the form of a reciprocal translocation has been reported for one other non-endemic Burkitt lymphoma [2]. The range of karyotypic anomalies observed in biopsy material of nonendemic Burkitt lymphoma varies from 14q + with other anomalies in a few instances (Table V: 17,20) to translocations involving chromosome 8 (Table V: 3, 4, 5) and to untreated tumours with other extensive chromosomal changes (Table V: 8,11,20). In addition the incidence of tumour cells with a 14q+ or 8; 14 translocation in untreated cases has been reported as being less than 100% [2, 201.…”

Section: Discussionmentioning

confidence: 94%

“…Two variant translocations have been described, these involve chromosomes 2 and 8 [4-81 and chromosomes 8 and 22 [6,[9][10][11][12]. In every case chromosome 8 is the common factor with the break point in the 8q23/24 region.…”

Section: Introductionmentioning

confidence: 99%

“…Cytogenetic studies on endemic and non-endemic Burkitt lymphoma have shown in the majority of cases the presence of a translocation involving chromosomes 8 and 14, irrespective of the presence of the Epstein Barr virus in the tumour cells [l-31. Two variant translocations have been described, these involve chromosomes 2 and 8 [4-81 and chromosomes 8 and 22 [6,[9][10][11][12]. In every case chromosome 8 is the common factor with the break point in the 8q23/24 region.…”

Section: Introductionmentioning

confidence: 99%

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Cytogenetic studies on four cases of non‐endemic burkitt lymphoma

Slater

Behrendt

Heerde

1982

Med. Pediatr. Oncol.

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Cytogenetic studies carried out on four children with non-endemic Burkitt lymphoma showed: 1) Two with the typical translocation t(8;14)(q24;q23); 2) one with a variant t(2;8)(p11;q24); and 3) one with apparently normal chromosomes 8 and 14. Additional chromosomal variation was present in all four patients. Two were shown to have a duplication of part of the long arm of chromosome 1 (1q23 leads to 1q32 and 1q23 leads to 1q42). Epstein Barr virus studies on two patients showed that one was positive and the other negative. A comparison of these results with other non-endemic cases in the literature has been made revealing a wider range of chromosomal variation than has been hitherto reported for endemic cases. The finding that chromosome 8 is also involved in the variant translocations in Burkitt lymphoma suggests that its changes may contribute more to the tumour development than the than the 14q+.

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Chromosomal abnormalities in adult non‐endemic burkitt's lymphoma and leukemia: 22 new reports and a review of 148 cases from the literature

Kornblau

Goodacre

Cabanillas

1991

Hematological Oncology

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Tumour cell karyotypes from patients with Burkitt lymphoma (BL) or Burkitt's type leukemia (ALL3) were studied for correlation with survival, bone marrow and cerebral spinal fluid involvement (CSF), human immunodeficiency virus (HIV) serology, and for recurrent cytogenetic abnormalities. The records of 22 patients with BL from our institution and of 148 cases of BL and ALL3 reported in the literature with karyotypes were evaluated for clinical and cytological features. Overall survival was only 28 per cent and 88 per cent of deaths occurred within the first nine months after diagnosis. Those who survived at least 18 months were unlikely to relapse. Age and gender did not significantly affect survival. Patients presenting with advanced Ann Arbor stage, bone marrow or CSF involvement had lower survival rates. The association of translocations involving chromosome band 8q24 with this disease is confirmed. Sixty-two per cent of karyotypes had t(8;14)(q24;q32) translocations; the recognized variant translocations t(8;22)(q24;q11) and t(2;8)(p12;q24) affected 12 per cent and 9 per cent respectively. Seventeen per cent had abnormal karyotypes but no classic translocation. Patients with variant translocations had the poorest survival rates, and those with the classic t(8;14)(q24;q32) did the best. Despite a small sample size, the variant translocation t(8;22)(q24;q11) appeared to occur at an increased frequency in the patients with AIDS. In the entire group, recurrent involvement of chromosome regions 1q2, 6q11-14 and 17p1 suggests that alteration of genes at these loci, B Cell Growth Factor (BCGF) at 1q2 and p53 on 17p, may contribute to the development and progression of this tumour. Similarly, the frequent trisomies of chromosomes 7, 8, 12 and 18 may indicate an effect on tumour cell growth due to increased gene dosage. Trisomy 12 was found in eight tumours, five from patients with AIDS, suggesting that chromosome 12 has a site or gene whose allelic dosage is selected for in AIDS related lymphoma cells. Cytogenetic studies of adult Burkitt lymphoma and leukemia suggest several likely loci for gene alterations that in conjunction with myc translocations can lead to tumorigenesis.

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Variant translocation in Burkitt's lymphoma: 8;22 translocation in a french patient with an Epstein-Barr virus-associated tumor

Cited by 13 publications

References 14 publications

EBV‐positive Burkitt's lymphoma from algeria, with a three‐way rearrangement involving chromosomes 2, 8 and 9

EBV‐positive Burkitt's lymphoma from algeria, with a three‐way rearrangement involving chromosomes 2, 8 and 9

Cytogenetic studies on four cases of non‐endemic burkitt lymphoma

Chromosomal abnormalities in adult non‐endemic burkitt's lymphoma and leukemia: 22 new reports and a review of 148 cases from the literature

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