Variaciones en la prevención del riesgo cardiovascular: estudio poblacional

Ruiz-Pérez, Isabel; Rincón, JM Ramos; Hernández-Aguado, Ildefonso

doi:10.1157/13043419

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Aunque no tan numerosos también existen algunos trabajos realizados en atención primaria de salud que exploran la variabilidad en el consumo de recursos 8 , en la realización de actividades preventivas 9 , en la calidad de la atención prestada en algunos procesos crónicos 10,11 , en la frecuentación a consultas 12 o en la prescripción de medicamentos 13,14 .…”

Section: Introductionunclassified

Variabilidad en la prescripción farmacéutica de atención primaria en Castilla La Mancha durante 2003

Castro

Fernández

et al. 2005

Rev. Esp. Salud Publica

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Section: Introductionunclassified

Variabilidad en la prescripción farmacéutica de atención primaria en Castilla La Mancha durante 2003

Castro

Fernández

et al. 2005

Rev. Esp. Salud Publica

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Economic Evaluation of Cardio inCode®, a Clinical-Genetic Function for Coronary Heart Disease Risk Assessment

Arellano

Coca

Figuera

et al. 2013

Appl Health Econ Health Policy

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Background A clinical-genetic function (Cardio inCode Ò ) was generated using genetic variants associated with coronary heart disease (CHD), but not with classical CHD risk factors, to achieve a more precise estimation of the CHD risk of individuals by incorporating genetics into risk equations [Framingham and REGICOR (Registre Gironí del Cor)]. Objective The objective of this study was to conduct an economic analysis of the CHD risk assessment with Cardio inCode Ò , which incorporates the patient's genetic risk into the functions of REGICOR and Framingham, compared with the standard method (using only the functions). Methods A Markov model was developed with seven states of health (low CHD risk, moderate CHD risk, high CHD risk, CHD event, recurrent CHD, chronic CHD, and death). The reclassification of CHD risk derived from genetic information and transition probabilities between states was obtained from a validation study conducted in cohorts of REGICOR (Spain) and Framingham (USA). It was assumed that patients classified as at moderate risk by the standard method were the best candidates to test the risk reclassification with Cardio inCode Ò . The utilities and costs (€; year 2011 values) of Markov states were obtained from the literature and Spanish sources. The analysis was performed from the perspective of the Spanish National Health System, for a life expectancy of 82 years in Spain. An annual discount rate of 3.5 % for costs and benefits was applied. Results For a Cardio inCode Ò price of €400, the cost per QALY gained compared with the standard method [incremental cost-effectiveness ratio (ICER)] would be €12,969 and €21,385 in REGICOR and Framingham cohorts, respectively. The threshold price of Cardio inCode Ò to reach the ICER threshold generally accepted in Spain (€30,000/QALY) would range between €668 and €836. The greatest benefit occurred in the subgroup of patients with moderate-high risk, with a high-risk reclassification of 22.8 % and 12 % of patients and an ICER of €1,652/QALY and €5,884/QALY in the REGICOR and Framingham cohorts, respectively. Sensitivity analyses confirmed the stability of the study results. Conclusions Cardio inCodeÒ is a cost-effective risk score option in CHD risk assessment compared with the standard method.

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Variability in the clinical practice of maintaining the patency of peripheral intravenous catheters

et al. 2005

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Variaciones en la prevención del riesgo cardiovascular: estudio poblacional

Cited by 3 publications

References 11 publications

Variabilidad en la prescripción farmacéutica de atención primaria en Castilla La Mancha durante 2003

Variabilidad en la prescripción farmacéutica de atención primaria en Castilla La Mancha durante 2003

Economic Evaluation of Cardio inCode®, a Clinical-Genetic Function for Coronary Heart Disease Risk Assessment

Variability in the clinical practice of maintaining the patency of peripheral intravenous catheters

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