Variables associated with malondialdehyde level in thalassemia major patients

Abstract

Background Thalassemia is the most common hereditary haemolytic

Analysis of Dl--Tocopherol as Antioxidant on Malondialdehyde Level in Pediatric Patients With -Thalassemia Major

“…The results of this study are supported by previous studies showing that there is no correlation between MDA level with the use of vitamin E regularly because in the process of sampling were difficult to divide the sample in a balanced proportion between the age group, gender, and other variables so that distribution statistics are spacious which led the research becomes insignificant (Gunarsih, et al, 2012;Saud, 2012).…”

“…-thalassemia homozygot patients had mean MDA level was higher than MDA level in -thalassemia/HbE patients, similar to the result of this study, -thalassemia homozygous patients had mean MDA level was higher than MDA level in -thalassemia/HbE level, but the result of data analysis were not significant (Gunarsih, et al, 2012). -thalassemia/HbE based on the pathogenesis of the disease is milder than -thalassemia homozygous for patients with -thalassemia/HbE be able to compen-sate for anemia than -thalassemia homozygous due to the nature of HbE and mean level of HbF lower than mean level of HbF -thalasemia homozygous (Fucharoen & Weatherall, 2012) so that the number of transfusions in patients with thalassemia type -thalassemia homozygous were more than thalassemia patients with -thalassemia/HbE type so Ferritin and MDA production was higher in patients with -thalassemia homozygous (Goswami, et al, 2005).…”

“…-thalassemia/HbE based on the pathogenesis of the disease is milder than -thalassemia homozygous for patients with -thalassemia/HbE be able to compen-sate for anemia than -thalassemia homozygous due to the nature of HbE and mean level of HbF lower than mean level of HbF -thalasemia homozygous (Fucharoen & Weatherall, 2012) so that the number of transfusions in patients with thalassemia type -thalassemia homozygous were more than thalassemia patients with -thalassemia/HbE type so Ferritin and MDA production was higher in patients with -thalassemia homozygous (Goswami, et al, 2005). In this study, in addition to the homozygous ß-thalassemia patients had a higher level of MDA than -thalassemia/HbE patients, but also had lower level of serum Ferritin, probably because homozygous -thalassemia patients had a younger mean age, shorter length of disease, and better nutritional status than thalassemia-/HbE subjects (Gunarsih, et al, 2012).…”