Analysis of Dl--Tocopherol as Antioxidant on Malondialdehyde Level in Pediatric Patients With -Thalassemia Major

Abstract

ABSTRAK Talasemia merupakan bentuk anemia herediter yang mempengaruhi sintesis hemoglobin. Penatalaksanaan terapi pada pasien -talasemia mayor yaitu pasien harus menerima transfusi darah terus menerus dan peningkatan absorpsi besi dari saluran pencernaan menyebabkan kelebihan besi pada tubuh. Peningkatan kadar besi dalam tubuh menyebabkan peningkatan besi bebas yang memicu Radical Oxygen Species (ROS ABSTRACT Thalassemia is a hereditary form of anemia that affects the synthesis of hemoglobin. The management of therapy in patients with -thalassemia major which patients should receive continuous blood transfusions and increased iron absorption from the digestive tract causes excess iron in the body. This will lead to an increase of free iron level that triggers Radical Oxygen Species (ROS). Increased level of ROS can initiate lipid peroxidation which used as an indicator of oxidative stress in cells and tissues and produce reactive carbonyl, mainly malondialdehyde (MDA). Thus, MDA measurement is widely used as an indicator of lipid peroxidation. On the other hand, the risk of oxidative damage can be reduced by antioxidant, one of them is Vitamin E that is a fat-soluble vitamin with high potential antioxidant. The objective of this study was to analyze the effect of the dl--tocopherol (Vitamin

Clinical pathology aspect on diagnosis cholelithiasis in β-Thalassemia patient: A case report

“…This continuous transfusion can result in iron overload in many organs, such as the heart, liver, kidneys, endocrine organs and others. The accumulation of free iron (ferrous iron/Fe2+) can cause a Fenton reaction that forms free radicals, causing oxidative stress, which will oxidize cell lipid membranes (lipid peroxidation) and nucleic acid modification, causing cell death, tissue damage and ultimately organ damage [ [9] , [10] , [11] ].…”