1982
DOI: 10.1007/bf03189564
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Variable first-pass elimination of propranolol following single and multiple oral doses in hypertensive patients

Abstract: The disposition of orally administered propranolol has been studied in twelve patients with mild to moderate hypertension. Each patient received single doses of 40, 80, and 160 mg. Serial blood samples were obtained and quantitated using a sensitive gas chromatographic analytical technique. Ten of the twelve patients received 40 mg doses of propranolol every 6 hours for 5 doses. Blood samples were obtained after administration of the first, second, third, and fifth doses. Substantial intersubject variability i… Show more

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Cited by 7 publications
(1 citation statement)
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“…Such behavior could be a source of variability in drug response. There are numerous examples in the literature describing the time-dependent pharmacokinetics of drugs [13,14]. The most common cause of time-dependent kinetics are variations in enzyme induction, diurnal variations in renal function, urine pH, h 1 -acid glycoprotein concentration, gastrointestinal physiology, cardiac output and regional blood flow [15].…”
Section: Discussionmentioning
confidence: 99%
“…Such behavior could be a source of variability in drug response. There are numerous examples in the literature describing the time-dependent pharmacokinetics of drugs [13,14]. The most common cause of time-dependent kinetics are variations in enzyme induction, diurnal variations in renal function, urine pH, h 1 -acid glycoprotein concentration, gastrointestinal physiology, cardiac output and regional blood flow [15].…”
Section: Discussionmentioning
confidence: 99%