Variability of the Rhesus Antigen D

Renton, P. H.; Hancock, Jeanne A.

doi:10.1111/j.1365-2141.1956.tb06701.x

Cited by 21 publications

(11 citation statements)

References 8 publications

(6 reference statements)

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“…The results are shown in table I. Dr. C. GILES at the B.G.R.L. confirmed these observations, finding M. P.'s cells to react with incomplete Rh antisera in a saline medium as follows: 4 out of 5 anti-C; all of 5 anti-D, 4 anti-E, 4 anti-c and 3 anti-e. Additional experiments showed M. P.'s cells were capable of specific absorption and subsequent elution of anti-D, anti-E and anti-c antibodies. (Suitable a n t i 4 and anti-e were not available.)…”

Section: P's Red Cell Antigenssupporting

confidence: 52%

“…There is insufficient evidence in the data presented here to say it is genetically independent of other blood group systems but whether it is or is not there is no doubt of its unique modifying effects on several other independent red cell antigen systems. Strong D antigens have been described [4] and others are mentioned by Race and Sanger [5] as reacting in sahne suspension with incomplete anti-D sera, although not of -D-type : such bloods may well bear further investigation now.…”

Section: Discussionmentioning

confidence: 84%

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The En^a Antigen and Antibody A Genetical Modification of Human Red Cells Affecting their Blood Grouping Reactions

Darnborough¹,

Dunsford²,

Wallace³

1969

Vox Sanguinis

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The red cells from a 23-year-old pregnant woman gave very unusual blood grouping reactions and her serum contained a ‘new’ antibody active against a very high incidence antigen. The reactions of various unrelated blood group antigens are modified, in some cases enhanced and in others depressed, the total picture being strongly reminiscent of the effects of proteolytic enzyme treatment. It is suggested that these effects can only be due to some factor affecting the red cell structure possibly by modifying the cell envelope. This modifying factor is genetically determined and shows dosage effect. Of nine siblings three are apparently homozygous and four heterozygous for this factor, the other two being ‘normal’. It is extremely rare, no further examples having been found in 18,472 blood donors. The antibody is undoubtedly immune, probably due to a blood transfusion two years previously. 12,509 donors have been tested with it but the only compatible red cells are those of the three homozygous siblings, i.e. the propositus, one sister and one brother. The antibody is therefore related to the modifying factor. Two codominant genes En^a and En^b are postulated, En^b being exceedingly rare. It is suggested that these genes determine not only the presence of the corresponding antigens Ena and Enb but also the structure of the red cell. EnaEna = ‘Normal’. EnaEnb = ‘Single dose modified’. EnbEnb = ‘Double dose modified’. The antibody thus becomes anti-En^a.

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Section: P's Red Cell Antigenssupporting

confidence: 52%

Section: Discussionmentioning

confidence: 84%

The En^a Antigen and Antibody A Genetical Modification of Human Red Cells Affecting their Blood Grouping Reactions

Darnborough¹,

Dunsford²,

Wallace³

1969

Vox Sanguinis

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show abstract

“…This superiority of the D anti gen in the cDE/cDE genotype has been referred to by Stratton [14] and Boorman and Dodd [1] and studied by Levine, Celano, Lange and Stroop [7]. Renton and Hancock [12] examined 5 blood samples se lected from 653 random samples which showed superior D activity because they reacted in saline with incomplete anti-D. These samples were not from -D-heterozygotes and there is some evidence that this stronger D antigen may be inherited.…”

Section: (Ii 6 8)mentioning

confidence: 78%

A Serological Study of -D- Heterozygotes in the Same Family

Lawler¹,

Marshall²

1962

Vox Sanguinis

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“…Cells of genotype -D-j-D-have the greatest amount of D, and cDE/cDE cells contain more D than those of genotype CDejcDe or CDe/cde [5]. Table III summarises [7] have reported certain "strong" D positive cells which are not limited to these particular genotypes. By means of formoltreatment and subsequent testing by selected anti-D sera, using a combination of saline, albumin, papain and indirect anti-globulin techniques, one may similarly demonstrate that the resistance of the D antigen to formalin varies within the genotype.…”

mentioning

confidence: 99%