Variability of the Constituent Composition of Achillea millefolium Essential Oils in the Wild Flora of Dagestan

Раджабов, Г.К.; Aliev, A.M.; Мусаев, А. М.; Islamova, F. I.

doi:10.1007/s11094-022-02692-1

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…2. 0) undeca n-3-ol) a nd 11,11-dimethyl-4,8-bis(methylene)-are volatile compounds in Achillea millefolium essential oil (69), propolis (70), and this compound in Syzygium aromaticum extract has potential as an antifungal and nematicidal (71). Notably, 11,11-dimethyl-4,8-dimethylenebicyclo(7.2.0)undecan-3-ol is positively associated with antibacterial activity (72).…”

Section: Discussionmentioning

confidence: 99%

Computational and in vitro analyses of the antibacterial effect of the ethanolic extract of Pluchea indica L. leaves

Wahyuni,

Junairiah,

Rosyanti

et al. 2024

Biomed Rep

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The most common gram-negative, Escherichia coli, and gram-positive bacteria, Bacillus spp., have evolved different mechanisms that have caused the emergence of multi-drug resistance. As a result, drugs that block the bacterial growth cycle are needed. Here, in silico and in vitro studies were performed to assess compounds in the Pluchea indica leaf extract, a medicinal plant, that can inhibit bacterial proteins. Briefly, P. indica leaves were extracted using ethanol. The crude extract was then subjected to gas chromatography-mass spectrometry for metabolite screening. Molecular docking simulations with rhomboid protease (R pro ) (Protein data bank ID number: 3ZMI from E. coli and filamenting temperaturesensitive mutant Z (FtsZ) protein data bank ID number: 2VAM from Bacillus subtilis were performed. Moreover, the well diffusion method was used to confirm the antibacterial activity of P. indica leaf extract. A total of 10 compounds were identified in the P. indica extract and used for computational analysis. Based on drug-likeness prediction, P. indica compounds may be drug-like molecules. Binding affinity tests indicated that 10,10-Dimethyl-2,6-dimethylenebicyclo(7.2.0) 2.0) undecan-3-ol had the most negative values. Accordingly, these compounds may be potential ligands that bind to bacterial proteins. The root mean square fluctuation values was <2 Å, indicating stable fluctuation binding for the ligand-protein complex. According to in vitro antibacterial assays, a high concentration (50%) of the P. indica extract markedly inhibited E. coli and B. subtilis, with inhibitory zone diameters of 31.86±1.63 and 21.09±0.09 mm, respectively. Overall, the compounds in the P. indica leaf extract were identified as functional inhibitors of E. coli and B. subtilis proteins via in silico analysis. This may facilitate development of antibacterial agents.

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Section: Discussionmentioning

confidence: 99%

Computational and in vitro analyses of the antibacterial effect of the ethanolic extract of Pluchea indica L. leaves

Wahyuni,

Junairiah,

Rosyanti

et al. 2024

Biomed Rep

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“…Previous studies have mainly focused on the characterisation of essential oils and flavonoid components of the typical white morphotype of A. millefolium in relation to external and internal cues [13,[23][24][25][26]. However, to date, no study has reported a detailed investigation of the triterpenoid profile in A. millefolium parts of the plant.…”

Section: Introductionmentioning

confidence: 99%

Comparative Phytoprofiling of Achillea millefolium Morphotypes: Assessing Antioxidant Activity, Phenolic and Triterpenic Compounds Variation across Different Plant Parts

Raudone,

Vilkickyte,

Marksa

et al. 2024

Plants

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Achillea millefolium L., commonly known as yarrow, is a versatile and widely distributed plant species with a rich history of ethnopharmacological significance. This study aimed to evaluate the comparative differences of A. millefolium inflorescence morphotypes. The phytochemical profile of white and pink inflorescence morphotypes was characterised by a complex of thirty-four phenolic and triterpene compounds. The species has distinct morphotypes of white and pink inflorescence. Phenolic and triterpenic profiles were determined, and individual compounds were quantified in inflorescence, leaf, and stem samples of two morphotypes tested. The antioxidant activity of plant extracts was evaluated by free radical scavenging (ABTS) and ferric-reducing antioxidant power (FRAP) assays. Caffeoylquinic acids predominated in all parts of the plant tested. Chlorogenic acid and 3,5-dicaffeoylquinic acid were the principal compounds in the phenolic profile. Betulin, betulinic acid, and α-amyrin were the prevailing triterpenic components in the triterpenic profiles of Achillea millefolium morphotypes. The predominant flavonoids in inflorescences were flavones, while in leaves, flavonols were the organ-specific compounds. The quantitative differences were observed between plant parts of morphotypes. Leaves consistently displayed the highest amounts of identified compounds and have been testified as the main source of antioxidant activity. Overall, white inflorescences accumulated a higher total amount of compounds compared to pink ones. The observed differences between morphotypes derived from the same population reflect the differences in specialised metabolites and their chemotypes. This study addresses gaps in knowledge, particularly in phenolic and triterpenic profiling of coloured inflorescence morphotypes, enhancing our understanding of chemotypes and morphotypes within the species.

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“…Studies on the chemical composition of A. millefolium date back to the early 1900s and more than 120 compounds have been identified [10]. Investigations on the chemical composition of essential oils and other extracts obtained from A. millefolium have been carried out in many countries [11][12][13][14][15][16][17] including Italy [9,13,18,19]. However, only a few reports have considered flower color in the composition of A. millefolium.…”

Section: Introductionmentioning

confidence: 99%

SPME-GC-MS Analysis of the Volatile Profile of Three Fresh Yarrow (Achillea millefolium L.) Morphotypes from Different Regions of Northern Italy

et al. 2023

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Achillea millefolium L. is the most representative plant of the genus Achillea due to its long-standing use. Previous investigations have allowed for the identification of many chemical compounds including phenols, flavonoids, monoterpenes, sesquiterpenes, and their derivatives. However, only a few reports have considered flower color in relation to A. millefolium composition. In this work, the phytochemical analysis on the volatile content of fresh samples of three morphotypes—white, pink and deep pink—collected in different points of the Italian Alpine area, was performed by the SPME-GC-MS technique. The obtained data highlighted a high content of terpenic compounds in all of the investigated morphotypes with a general predominance of monoterpenes over sesquiterpenes with the exception of the white morphotype at collection point A (Saint Marcel, Valle d’Aosta). An in-depth statistical investigation was also carried out to better interpret the distribution of the various components both in relation to the morphotype and collection point.

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Variability of the Constituent Composition of Achillea millefolium Essential Oils in the Wild Flora of Dagestan

Cited by 5 publications

References 22 publications

Computational and in vitro analyses of the antibacterial effect of the ethanolic extract of Pluchea indica L. leaves

Computational and in vitro analyses of the antibacterial effect of the ethanolic extract of Pluchea indica L. leaves

Comparative Phytoprofiling of Achillea millefolium Morphotypes: Assessing Antioxidant Activity, Phenolic and Triterpenic Compounds Variation across Different Plant Parts

SPME-GC-MS Analysis of the Volatile Profile of Three Fresh Yarrow (Achillea millefolium L.) Morphotypes from Different Regions of Northern Italy

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