Variability of Target and Normal Structure Delineation for Breast-Cancer Radiotherapy: A RTOG Multi-Institutional and Multi-Observer Study

Automatic Segmentation of Whole Breast Using Atlas Approach and Deformable Image Registration

“…This is consistent with findings from the study by Hurkmans et al ., in which the largest deviations in the whole breast planning target volume were in the posterior region (4). Both our study and the Hurkmans study support the need for uniform consensus guidelines in breast target delineation, and in fact the Radiation Therapy Oncology Group has formed a working group to discuss and resolve this issue (15). …”

Evaluation of Automatic Atlas-Based Lymph Node Segmentation for Head-and-Neck Cancer

“…Variability is one of the most challenging issues in the IMRT era and recognition of this fact has motivated recent efforts to quantify variability and develop systematic approaches to improve consistency (15). The ability to accurately and precisely identify target volumes impacts dose delivery to both tumor and normal structures.…”

Comparison Between Hybrid Direct Aperture Optimized Intensity-Modulated Radiotherapy and Forward Planning Intensity-Modulated Radiotherapy for Whole Breast Irradiation

“…Typically, the field borders were extended to the midline medially, at the lower border of the clavicle superiorly, and 2 cm beyond the palpable breast tissue laterally and inferiorly. A recent study indicated that no consensus has been reached on the definition of the breast-CTV among radiation oncologists specialized in breast cancer (33). For a fair comparison between FP-IMRT and hDAO-IMRT in this retrospective study, the breast-CTV was defined by converting the 50-Gy isodose line of the original FP-IMRT plans into a contour.…”