Variability of perfluoroalkyl substance concentrations in pregnant women by socio-demographic and dietary factors in a Spanish birth cohort

Manzano-Salgado, Cyntia B.; Casas, Maribel; Lopez-Espinosa, Maria-José; Ballester, Ferrán; Martínez, David; Ibarluzea, Jesús; Santa‐Marina, Loreto; Schettgen, Thomas; Vioque, Jesús; Sunyer, Jordi; Vrijheid, Martine

doi:10.1016/j.envint.2016.04.004

Cited by 77 publications

(83 citation statements)

References 58 publications

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“…This gender difference has been consistently reported across studies (Calafat et al 2007;Hölzer et al 2008;Frisbee et al 2009;Ingelido et al 2010;Ingelido et al 2018) but its mechanisms have not been fully elucidated. Pregnancy, delivery, and lactation are known excretion routes for women (Kärrman et al 2007;Zhang T et al 2013;Mondal et al 2014;Cariou et al 2015;Manzano-Salgado et al 2015), and previous childbirth and breastfeeding have been inversely associated with serum PFAS in several studies (Brantsaeter et al 2013;Lauritzen et al 2016;Manzano-Salgado et al 2016;Bartolomé et al 2017). This finding is confirmed in the present study where serum concentrations of PFOA, PFOS, and PFHxS progressively decreased with increasing number of previous deliveries.…”

Section: Discussionsupporting

confidence: 87%

“…The concentrations of all the three PFAS increased with alcohol intake. We think these associations should be taken cautiously because previous studies have shown varying results (Steenland et al 2009;Nelson et al 2010;Brantsaeter et al 2013;Lauritzen et al 2016;Manzano-Salgado et al 2016;Bartolomé et al 2017;Lee et al 2017), and the mechanisms are unclear.…”

Section: Discussionmentioning

confidence: 94%

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Serum Levels of Perfluoroalkyl Substances (PFAS) in Adolescents and Young Adults Exposed to Contaminated Drinking Water in the Veneto Region, Italy: A Cross-Sectional Study Based on a Health Surveillance Program

Pitter

Canova

et al. 2020

Environ Health Perspect

121

108

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BACKGROUND: In spring 2013, groundwater of a vast area of the Veneto Region (northeastern Italy) was found to be contaminated by perfluoroalkyl substances (PFAS) from a PFAS manufacturing plant active since the late 1960s. Residents were exposed to high concentrations of PFAS, particularly perfluorooctanoic acid (PFOA), through drinking water until autumn 2013. A publicly funded health surveillance program is under way to aid in the prevention, early diagnosis, and treatment of chronic disorders possibly associated with PFAS exposure. OBJECTIVES: The objectives of this paper are: a) to describe the organization of the health surveillance program, b) to report serum PFAS concentrations in adolescents and young adults, and c) to identify predictors of serum PFAS concentrations in the studied population. METHODS: The health surveillance program offered to residents of municipalities supplied by contaminated waterworks includes a structured interview, routine blood and urine tests, and measurement of 12 PFAS in serum by high-performance liquid chromatography-tandem mass spectrometry. We studied 18,345 participants born between 1978 and 2002, 14-39 years of age at recruitment. Multivariable linear regression was used to identify sociodemographic, lifestyle, dietary, and reproductive predictors of serum PFAS concentrations. RESULTS: The PFAS with the highest serum concentrations were PFOA [median 44:4 ng=mL, interquartile range (IQR) 19.3-84.9], perfluorohexanesulfonic acid (PFHxS) (median 3:9 ng=mL, IQR 1.9-7.4), and perfluorooctanesulfonic acid (PFOS) (median 3:9 ng=mL, IQR 2.6-5.8). The major predictors of serum levels were gender, municipality, duration of residence in the affected area, and number of deliveries. Overall, the regression models explained 37%, 23%, and 43% of the variance of PFOA, PFOS, and PFHxS, respectively. CONCLUSIONS: Serum PFOA concentrations were high relative to concentrations in populations with background residential exposures only. Interindividual variation of serum PFAS levels was partially explained by the considered predictors.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 94%

Serum Levels of Perfluoroalkyl Substances (PFAS) in Adolescents and Young Adults Exposed to Contaminated Drinking Water in the Veneto Region, Italy: A Cross-Sectional Study Based on a Health Surveillance Program

Pitter

Canova

et al. 2020

Environ Health Perspect

121

108

View full text Add to dashboard Cite

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“…Mother–child pairs were then assessed when children were 4 and 7 y old. Maternal PFAS concentrations were measured in serum samples from 1,243 women (58% of the initial cohort) who participated in follow-up when their children were 4 y of age ( Manzano-Salgado et al 2016 ). The present analysis was limited to mother–child pairs with prenatal PFAS concentrations and weight gain data for children at 6 mo (

), and with BMI at 4 y (

) and 7 y (

) ( Figure 1 ).…”

Section: Methodsmentioning

confidence: 99%

“…WC was measured using an inelastic tape (SECA model 201; SECA) at the midpoint between the right lower rib and the iliac crest, and after a slight breath out. We derived age-, sex-, and region-specific WC z -scores as the standardized residuals from a regression model of WC as the dependent variable, and age, sex, and region as the predictors, following the method of Eisenmann ( 2008 ), with standardization by region used to account for differences among the three regional subcohorts (Table S1) ( Manzano-Salgado et al 2016 ). We used WC (cm) and height (cm) to calculate the WHtR, and defined high abdominal adiposity as

based on previous studies ( Graves et al 2014 ; Martin-Calvo et al 2016 ; Mokha et al 2010 ).…”

Section: Methodsmentioning

confidence: 99%

“…At enrollment (during the first trimester of pregnancy), mothers provided blood samples and completed self-reported questionnaires on sociodemographic and dietary factors, including the maternal country of birth (Spain or other), region of residence (Gipuzkoa, Sabadell, and Valencia), parity (0, 1, and

), age (in years), and weekly intakes of fish and seafood consumption during the previous 3 mo of pregnancy (based on a food frequency questionnaire) ( Manzano-Salgado et al 2016 ). In INMA, mothers self-reported the duration of previous breastfeeding as the total number of weeks for any previous pregnancy.…”

Section: Methodsmentioning

confidence: 99%

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Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study

Manzano-Salgado

Casas

Lopez-Espinosa

et al. 2017

Environ Health Perspect

Self Cite

117

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Background:Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, but evidence is scarce and inconsistent.Objectives:We estimated associations between prenatal PFAS exposures and outcomes relevant to cardiometabolic risk, including a composite CM-risk score.Methods:We measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in maternal plasma (first trimester). We assessed weight gain from birth until 6 mo. At 4 and 7 y, we calculated the age- and sex-specific z-scores for BMI, waist circumference (WC), and blood pressure (BP) (n≈1,000). At age 4, we calculated the age-, sex-, and region-specific z-scores for cholesterol, triglycerides (TGs), high-density (HDL-C), and low-density lipoprotein cholesterol (LDL-C) (n=627). At age 4, we calculated a CM-risk score (n=386) as the sum of the individual age-, sex-, and region-specific z-scores for WC, BP, HDL-C, and TGs. We used the average between the negative of HDL-C z-score and TGs z-score to give similar weight to lipids and the other components in the score. A higher score indicates a higher cardiometabolic risk at age 4.Results:PFOS and PFOA were the most abundant PFAS (geometric mean: 5.80 and 2.32 ng/mL, respectively). In general, prenatal PFAS concentrations were not associated with individual outcomes or the combined CM-risk score. Exceptions were positive associations between prenatal PFHxS and TGs z-score [for a doubling of exposure, β=0.11; 95% confidence interval (CI): 0.01, 0.21], and between PFNA and the CM-risk score (β=0.60; 95% CI: 0.04, 1.16). There was not clear or consistent evidence of modification by sex.Conclusions:We observed little or no evidence of associations between low prenatal PFAS exposures and outcomes related to cardiometabolic risk in a cohort of Spanish children followed from birth until 7 y. https://doi.org/10.1289/EHP1330

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Suggestions for Improving the Characterization of Risk from Exposures to Per and Polyfluorinated Alkyl Substances

Mikkonen

Martin²,

Dourson

et al. 2021

Enviro Toxic and Chemistry

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Many state and federal environmental and health agencies have developed risk‐based criteria for assessing the risk of adverse health effects of per‐ and polyfluorinated alkyl substances (PFAS) exposure to humans and the environment. However, the criteria that have been developed vary; drinking water criteria developed for perfluorooctanoic acid, for example, can vary by up to 750 fold. This is due to differences and variability in the data and information used, study/endpoint selection, assumptions and magnitude of uncertainty factors used in the absence and extrapolation of critical effect data, differences in underlying approaches to addressing exposure within criteria development, and/or policy decisions on levels of acceptable risk. We have critically evaluated the methods used to develop these criteria while focusing on derivation and application of drinking water criteria and discuss a range of improvements to risk‐characterization practice recently presented at a Focused Topic Meeting on PFAS conducted by the Society of Environmental Toxicology and Chemistry in Durham, North Carolina, USA, 12 to 15 August 2019. We propose methods that consider maximizing the use of disparate data streams, seeking patterns, and proposing biologically based approaches to evidence integration toward informed criteria development. Environ Toxicol Chem 2021;40:883–898. © 2020 SETAC

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Variability of perfluoroalkyl substance concentrations in pregnant women by socio-demographic and dietary factors in a Spanish birth cohort

Cited by 77 publications

References 58 publications

Serum Levels of Perfluoroalkyl Substances (PFAS) in Adolescents and Young Adults Exposed to Contaminated Drinking Water in the Veneto Region, Italy: A Cross-Sectional Study Based on a Health Surveillance Program

Serum Levels of Perfluoroalkyl Substances (PFAS) in Adolescents and Young Adults Exposed to Contaminated Drinking Water in the Veneto Region, Italy: A Cross-Sectional Study Based on a Health Surveillance Program

Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study

Suggestions for Improving the Characterization of Risk from Exposures to Per and Polyfluorinated Alkyl Substances

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