Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study

Manzano-Salgado, Cyntia B.; Casas, Maribel; Lopez-Espinosa, Maria-José; Ballester, Ferrán; Íñiguez, Carmen; Martínez, David; Romaguera, Dora; Fernández–Barrés, Sílvia; Santa‐Marina, Loreto; Basterretxea, Mikel; Schettgen, Thomas; Valvi, Damaskini; Vioque, Jesús; Sunyer, Jordi; Vrijheid, Martine

doi:10.1289/ehp1330

Cited by 85 publications

(128 citation statements)

References 64 publications

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“…Trained staff measured WC using an inelastic tape (SECA model 201; SECA, Hamburg, Germany), measured in the midpoint between the right lower rib and the iliac crest, and after a slight breath out. Regression models were used to derive WC z‐scores standardized by age, sex, height, and cohort . At 4 years, WC measurement was not collected in the Gipuzkoa region.…”

Section: Methodsmentioning

confidence: 99%

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Impact of lifestyle behaviors in early childhood on obesity and cardiometabolic risk in children: Results from the Spanish INMA birth cohort study

et al. 2019

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Summary Background Identifying modifiable lifestyle behaviors linked to childhood obesity is necessary to develop preventive strategies. Objective To estimate the association of five lifestyle behaviors in children aged 4 years on obesity and cardiometabolic risk factors at age 4 years and on obesity and blood pressure at age 7 years. Methods We used child lifestyle data from the INMA project at age 4 years (n = 1480). We constructed a child lifestyle score by summing five behaviors (physical activity, sleep time, television time, plant based foods and intake of ultra‐processed foods) and we categorized it into tertiles. At ages 4 and 7 years, we calculated age‐ and sex‐specific z‐scores for BMI, waist circumference (WC), and blood pressure. At age 4, we also calculated age‐, and sex‐, specific z‐scores for triglycerides and HDL. We used linear and logistic regression analyses. Results The lifestyle score was not associated with the outcomes at 4 years, but it was negatively associated with BMI and WC z‐scores at age 7 years. Children at age 4 years in the highest tertile of the score had lower risk of overweight or obesity at age 7 years (OR = 0.61; 95% CI 0.39; 0.96) and abdominal obesity (OR = 0.48; 95% CI 0.24; 0.96). Conclusions Higher adherence to a healthy lifestyle at age 4 years decreased risk of overweight, obesity and abdominal obesity at 7 years.

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Section: Methodsmentioning

confidence: 99%

“…Regression models were used to derive WC zscores standardized by age, sex, height, and cohort. 29 At 4 years, WC measurement was not collected in the Gipuzkoa region. Abdominal obesity was defined as WC z-score > 1 SD.…”

Section: Anthropometric Measurementsmentioning

confidence: 99%

Impact of lifestyle behaviors in early childhood on obesity and cardiometabolic risk in children: Results from the Spanish INMA birth cohort study

et al. 2019

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“…This has varied between studies with different levels of exposure and conflicts with other studies where null associations were reported. 39,40 Methodological considerations As previously noted, 5 it is important to rule out that the association between increasing PFAS levels and BW is mediated via shorter GA. Here we performed several different investigations of this issue and found no signs of such indirect effects.…”

Section: Different Associations In Girls and Boysmentioning

confidence: 99%

Maternal serum levels of perfluoroalkyl substances in early pregnancy and offspring birth weight

et al. 2019

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BACKGROUND: Perfluoroalkyl substances (PFASs) are widespread, bioaccumulating, and persistent and show placental transfer. Emerging research indicates associations between prenatal exposure and low birth weight. The aim of this study was to assess the associations between first trimester exposure to PFASs and birth weight (BW) in the Swedish Environmental, Longitudinal, Mother and child, Asthma and allergy (SELMA) study and examine whether associations differ between girls and boys. METHODS: Eight PFASs were analyzed in maternal serum (median: 10 weeks of pregnancy). Associations between prenatal PFAS exposure and birth outcomes with BW, BW for gestational age, and birth small for gestational age (SGA) were assessed in 1533 infants, adjusted for potential confounders and stratified by sex. RESULTS: Increased maternal perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) were associated with lower BW, lower BW for gestational age, and SGA birth. Associations were significant only in girls, where prenatal exposure in the upper quartile was associated with a 93-142-g lower BW when compared with that of the lowest quartile exposure. The associations were not mediated by effects on gestational age. CONCLUSIONS: We found associations between prenatal exposure for five different PFASs and birth weight, with more pronounced associations in girls than in boys.

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“…Among these substances, endocrine disruptor chemicals (EDCs), such as phthalates, bisphenol and hydroxypyrene, which can be found in oil and water resistant textile coatings, non-stick cookware, food container coatings, floor polish, fire-fighting foam, and industrial surfactants, are a class of suspected obesogenic contaminants persisting in the environment and humans [31]. EDCs have been also detected in cord blood samples, suggesting that exposure starts prenatally [32] and early life EDC exposures may perturb neuroendocrine systems involved in growth, energy metabolism, appetite, adipogenesis, and glucose-insulin homeostasis promoting childhood obesity development [33].…”

Section: Introductionmentioning

confidence: 99%

Prenatal and postnatal determinants in shaping offspring's microbiome in the first year of life. Preliminary results.

Raspini¹,

Porri²,

Giuseppe³

et al. 2019

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Background Fetal programming during in utero life defines the set point of physiological and metabolic responses that lead into adulthood; events happening in “the first 1,000 days” play a role in the development of non-communicable diseases (NCDs). The infant gut microbiome is a highly dynamic organ, which is sensitive to maternal factors and environmental insults; it modifies its composition over the host’s lifespan and is one of the elements driving this intergenerational NCDs' transmission. The A.MA.MI (Alimentazione MAmma e bambino nei primi MIlle giorni) project aims at investigating the possible correlation between pre-natal and post-natal factors and the infant gut microbiome composition, during the first year of life at different follow-up. We describe the study design of the A.MA.MI Study and present some preliminary results.Methods A.MA.MI is a longitudinal, prospective, observational study that includes a group of mother-infant pairs (n=63) attending the Neonatal Unit, Fondazione IRCCS Policlinico San Matteo, Pavia (Italy). The study was planned to provide data collected before discharge (T0) and at 1,6,12 months after birth (T1,T2,T3). Maternal and infant anthropometric measurements are assessed at each time. Other variables evaluated are pre-pregnancy/gestational weight status (T0), maternal dietary habits/physical activity (T1-T3); infant medical history, type of feeding, antibiotics/probiotics/supplements use, environment exposures (e.g cigarette smoking, pets, environmental temperature) (T1-T3). A child stool sample was planned to be collected at each time and analyzed using metagenomics 16S ribosomal RNA gene sequence-based methods. Maternal urine samples were planned to be collected at T3 to investigate pollutants exposure (Phthalates, Bisphenol A and Hydroxypyrene).Results Concerning the birth mode (cesarean section vs. vaginal delivery) significant differences were found only at genera and species levels (T0). A significantly higher relative abundance of Firmicutes was found in meconium of infants born from mothers affected by overweight/obesity, when compared to women with normal weight before pregnancy (T0). Regards type of feeding (breastfed vs formula-fed) the gut microbiota composition differed significantly only at genus and species level (T1).Conclusion These preliminary and explorative results confirmed that pre-pregnancy BMI, mode of delivery and infant factors could affect the infant microbiota composition at different levels.

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Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study

Cited by 85 publications

References 64 publications

Impact of lifestyle behaviors in early childhood on obesity and cardiometabolic risk in children: Results from the Spanish INMA birth cohort study

Impact of lifestyle behaviors in early childhood on obesity and cardiometabolic risk in children: Results from the Spanish INMA birth cohort study

Maternal serum levels of perfluoroalkyl substances in early pregnancy and offspring birth weight

Prenatal and postnatal determinants in shaping offspring's microbiome in the first year of life. Preliminary results.

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