Variability of Genetic Load with Changing Socio-Cultural Environment

Srikumari, C. R.; Rajanikumari, J.; Rao, T. V.

doi:10.1159/000153585

Cited by 8 publications

(2 citation statements)

References 9 publications

(17 reference statements)

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“…In fact, the recently reported high inbreeding coefficient (0.0225) of the Iraqi population puts Iraq among the highest in the world except perhaps for strongly isolated socie ties with a high genetic load [Indira et al, 1976;Inbaraj, 1979, 1980;Srikumari et al, 1985], Hamamy et al [1986] have calculated the Iraqi inbreeding coef ficient from their data of 29.2% first-cou- sins marriages, 10.1% first cousins once removed marriages, 17.1 % second-cousins marriages and 11.4% of marriages be tween beyond second cousins among a to tal of 4,491 marriages.…”

Section: Introductionmentioning

confidence: 99%

Consanguinity and Reproductive Health in Iraq

Hamamy

Al-Hakkak²

1989

Hum Hered

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This study investigated the consanguinity rate of 233 families with severely disturbed reproductive health, and compared it to that of 227 families with normal (moderate) levels of reproductive wastage and to that of 155 families with no reproductive disturbance. The results showed that the inbreeding coefficients of the three groups of families were 0.0358, 0.0241 and 0.0208, respectively. Furthermore, the rate of congenital malformations was found to be highly correlated with the consanguinity rate of these families.

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Section: Introductionmentioning

confidence: 99%

Consanguinity and Reproductive Health in Iraq

Hamamy

Al-Hakkak²

1989

Hum Hered

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“…A number of studies conducted on effects of inbreeding in different populations revealed elevated levels [29,10,11,16,27,28,14,1,23] of prereproductive mortality among the offspring of consanguineous marriages. But, most of the studies conducted in India [18,20,21,13,9,2,3,32,22] did not reveal any significant effect of inbreeding on mortality. Lack of inbreeding effects in these populations support the Sanghvi's [25,26] contention that in areas where the current levels of inbreeding are high and where inbreeding has been the custom for over two milliennia or perhaps longer, the effects of inbreeding may not be perceptible.…”

Section: Introductionmentioning

confidence: 99%

Effects of Inbreeding on Reproductive Losses in Kota Tribe

Sivakumaran

Karthikeyan

1997

Acta genet. med. gemellol.: twin res.

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Sanghvi's hypothesis on long term effects of inbreeding was tested in Kotas. Kota is a numerically small tribal population in the Nilgiri district, Tamil Nadu State, India. Consanguineous marriages are common in this tribe. A total of 95 couples were taken for this study and necessary data were collected on a set proforma. Of the 95 couples, 28 (29.5%) were consanguineously related. The inbreeding coefficient for autosomal genes is 0.022 and for sex-linked genes is 0.03. Inbreeding effects on reproductive losses were examined through an exponential regression model. Although the regression coefficient B values are positive, they are insignificant, suggesting no consistent relationship between degree of consanguinity and the reproductive losses. The estimates of genetic load is 1.8 lethal equivalents per gamete and the average B/A ratio is 5. These findings empirically support the Sanghvi's contention.

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Al-Abdulkareem

Ballal²

1998

Journal of Community Health

115

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The objective of this cross-sectional study was to determine the pattern and time trend of consanguineous marriage and its adverse health effects on the offspring in Dammam city, Eastern Province, in the Kingdom of Saudi Arabia. This city is known to attract Saudis from different parts of the country because it is in the heart of this industrial region. Five primary health care centers were randomly selected from different sectors of the city in addition to the city's only Maternity and Children's Hospital. For inclusion in the study a wife must have at least one pregnancy that terminated in either full term liveborn baby, still birth, or abortion. A total of 1307 ever-married Saudis completed a pre-structured questionnaire during an interview. The rate of consanguineous marriage was 52.0% with an average inbreeding coefficient of 0.0312. First-cousin marriages were the commonest (39.3%) of all matings. The consanguineous groups had a significantly higher number of pregnancies. The mean birth weight of the offspring of consanguineous couples was not statistically significant being less than that of the non-consanguineous. However, within the consanguineous groups the more closely related couples had smaller babies on average. No significant differences were noted for the rates of inherited diseases and reproductive wastage. The rate of consanguineous marriage in this city was high and so was the inbreeding coefficient. These figures place this nation among the countries with a high rate of consanguineous marriages. A nationwide study to determine accurately the relationship between consanguinity and inherited diseases has much to commend it.

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Variability of Genetic Load with Changing Socio-Cultural Environment

Cited by 8 publications

References 9 publications

Consanguinity and Reproductive Health in Iraq

Consanguinity and Reproductive Health in Iraq

Effects of Inbreeding on Reproductive Losses in Kota Tribe

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