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Al-Abdulkareem, Abdulkareem A.; Ballal, Seifeddin G.

doi:10.1023/a:1018727005707

Cited by 116 publications

(36 citation statements)

References 20 publications

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“…Such an imbalance of population has been in existence in the Kingdom on regional and urban scales (Makki 1986), which may have been due to cultural factors and the concentration of government and private spending (Al-Khalifeh 1993). These regions are highly developed, with metropolises and high levels of industrial and commercial activity (Khraif 2000; Al-Abdulkareem and Ballal 1998) – Ar-Riyad (Al-Riyad Region), Jeddah, and Makkah (Makkah Al-Mokarramah Region), and Dammam (Eastern Region). These metropolises attract not only the non-Saudi manpower from other countries but also the Saudi manpower from other regions, creating an imbalance of population in Northern Borders, Al-Jouf, Al-Baha, and Najran regions (Khraif 1994).…”

Section: Resultsmentioning

confidence: 99%

Population distribution and household conditions in Saudi Arabia: reflections from the 2010 Census

et al. 2014

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The Kingdom of Saudi Arabia, the largest nation in the Arabian Peninsula is divided into 13 regions, which are of different development levels in terms of both population and public utility infrastructure. More than the other regions, population is high in Al-Riyadh, Makkah Al-Mokarramah, and the Eastern Region, due to urbanization. The current analysis of census results is aimed at understanding (i) regional variations in population and households and (ii) house ownership, type of housing, and housing infrastructure.Saudi Arabia’s population is 26,090,555, living in 4,655,127 households with higher concentration in Al-Riyadh, Makkah Al-Mokarramah, and the Eastern Region. One-fourth of the households are in Makkah Al-Mokarrammah while another one-fourth in Al-Riyadh. Households are small with 6 persons in each. The proportion of households in own houses is less than half – mostly Saudi households. Households in the Kingdom live in apartments, traditional houses, villas or floor in a villa with differing proportions across regions and between Saudi and non-Saudi. While apartments are the major type of housing (major regions), traditional houses (Jazan, Al-Baha, Hail, and Aseer regions) and villas (Al-Riyadh region) still exist that are built by concrete (less than four-fifths), block/brick (less than one-fifth), mud (rare), and stone (rare) with varying regional proportions. Infrastructure – electricity, water, and sewage – vary across regions. The major source of electricity is public station followed by private station and private generators. Water source is mainly the public water inside the pipe unit but catchment tank water and well water are used. Three types of sewage system are prevalent in the Kingdom - public sewage, ditch sewage, and private sewage.An inequitable distribution of population across regions shows urbanization, causing an emergence of the modern housing sector influencing house ownership. Developed regions have less ownership, more rentals and office quarters, thus, presuming that development level and migration status are driving house ownership. The impact of infrastructural variations is difficult to interpret as such variations affect the interest of the public sector and customers. A lesser dependence on the public sector requires caution when assessing the situation and when creating policies and provisions to improve quality of life.

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Section: Resultsmentioning

confidence: 99%

Population distribution and household conditions in Saudi Arabia: reflections from the 2010 Census

et al. 2014

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“…The most frequent were first cousin marriages (28-4%) [28]. Consanguineous marriages were reported to be as high as 60% and this has provided a background in which these genetic diseases abound [29,30]. …”

Section: Discussionmentioning

confidence: 99%

Risk factors and birth prevalence of birth defects and inborn errors of metabolism in Al Ahsa, Saudi Arabia

Ali¹,

Balaha²,

Moghannum³

et al. 2011

Pan Afr Med Jrnl

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BackgroundBirth defects and inborn errors of metabolism are related to variable poor perinatal and neonatal outcomes. Our aim was to explore the pattern and prevalence of birth defects and metabolic birth errors in Al-Ahsa Governorate in the Eastern Province of Saudi Arabia.MethodsThis retrospective case control study was done from April 2006 to 2009. Children with any birth defect or metabolic errors of metabolism at birth or in the neonatology section were our sample for study. Control group was randomly selected from the cases with normal live births. Blood tests were performed for children suspected to suffer from genetic blood disorders. The principal BD as per the International Classification of Diseases-10 (ICD-10) code was also noted.ResultsOut of 38001 live births, birth defects were found in 1.14% and errors of metabolism were detected in 0.17%. The most common birth defects were craniofacial malformations. The 3-methylcrotonyl-CoA carboxylase deficiency was the most common inborn errors of metabolism. Consanguinity, rural residence and prematurity were associated with significant rise in birth defects. On the other hand, consanguinity and low birth weight were associated with significant rise in metabolic errors.ConclusionFirst cousins consanguinity represented the most significant risk factor for birth defects and inborn errors of metabolism. High degree of inbreeding, consanguinity may exacerbate underlying recessive genetic risk factors.

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“…Its exact prevalence is unknown, with approximately 230 cases described to date [5,6,8,9,12–49] (Supplemental Table 1). The majority of patients with DOCK8 deficiency are of Turkish and Arabic descent, populations in which consanguinity rates are high [50–52]. However, the condition has been identified in other populations throughout the world, including North and South America, Europe, and China [8,19,38].…”

Section: Epidemiologymentioning

confidence: 99%

DOCK8 deficiency: Insights into pathophysiology, clinical features and management

Biggs

Keleş

Chatila

2017

Clinical Immunology

138

119

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Dedicator of Cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency that exemplifies the broad clinical features of primary immunodeficiencies (PIDs), extending beyond recurrent infections to include atopy, autoimmunity and cancer. It is caused by loss of function mutations in DOCK8, encoding a guanine nucleotide exchange factor highly expressed in lymphocytes that regulates the actin cytoskeleton. Additional roles of DOCK8 have also emerged, including regulating MyD88-dependent Toll-like receptor signaling and the activation of the transcription factor STAT3. DOCK8 deficiency impairs immune cell migration, function and survival, and it impacts both innate and adaptive immune responses. Clinically, DOCK8 deficiency is characterized by allergic inflammation as well as susceptibility towards infections, autoimmunity and malignancy. This review details the pathophysiology, clinical features and management of DOCK8 deficiency. It also surveys the recently discovered combined immunodeficiency due to DOCK2 deficiency, highlighting in the process the emerging spectrum of PIDs resulting from DOCK protein family abnormalities.

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Cited by 116 publications

References 20 publications

Population distribution and household conditions in Saudi Arabia: reflections from the 2010 Census

Population distribution and household conditions in Saudi Arabia: reflections from the 2010 Census

Risk factors and birth prevalence of birth defects and inborn errors of metabolism in Al Ahsa, Saudi Arabia

DOCK8 deficiency: Insights into pathophysiology, clinical features and management

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