Variabilities in Weight and Waist Circumference and Risk of Myocardial Infarction, Stroke, and Mortality: A Nationwide Cohort Study

Kim, Da Hye; Nam, Ga Eun; Han, Kyungdo; Kim, Yang Hyun; Park, Kye Yeung; Hwang, Hwan Sik; Han, Byoungduck; Cho, Sung Jung; Jung, Seung Jin; Yoon, Yeo Joon; Roh, Yong Kyun; Cho, Kyung Hwan; Park, Yong Gyu

doi:10.3803/enm.2020.871

Cited by 17 publications

(18 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another longitudinal study of 4.4 years in 16,095 cases of myocardial infarction, 18,957 cases of stroke, and 30,200 cases of all-cause deaths demonstrated that increased variability of body weight and WC was associated with high risk for all three outcomes. These findings suggested that a variable, instead of a relatively stable body weight, either high or low, was associated with adverse prognosis [ 43 ]. A post-hoc breakdown of the SYNTAX Extended Survival study in patients with left main coronary artery disease that was revascularized either with coronary artery bypass surgery or percutaneous coronary intervention, showed that patients with either low baseline BMI and low WC, or low BMI/high WC, or high BMI/high WC, exhibited higher 10-year mortality risk compared to patients with high BMI/low WC.…”

Section: Discussionmentioning

confidence: 99%

Body Mass Index Is Independently Associated with the Presence of Ischemia in Myocardial Perfusion Imaging

et al. 2022

View full text Add to dashboard Cite

Background and Objectives: Obesity has been linked to various cardiovascular risk factors, increased incidence of coronary artery disease, and myocardial perfusion defects. The aim of this study was to investigate if body mass index (BMI) and waist circumference (WC) were associated with myocardial perfusion defects. Materials and Methods: A total of 308 consecutive patients who had myocardial perfusion imaging (MPI) with single photon emission computed tomography (SPECT) and a complete medical record on file were studied retrospectively. Results: The median age was 69 (61–76) years, the BMI was 27.6 (24.4–30.7) kg/m2, and the WC was 110 (102–118) cm. Of the 308 patients, 239 patients (77.6%) had myocardial ischemia. A positive test for ischemia was more frequent in men compared to women (72 vs. 28%, p < 0.001). Within the male group, BMI and WC were not significantly different between the ischemia and non-ischemia groups. In contrast, within the female group, both BMI (30.2 vs. 27.1 kg/m2, p = 0.002) and WC (112 vs. 105.5 cm, p = 0.020) were significantly higher in the ischemia group. Multivariable logistic regression showed that male sex and BMI were the only two independent predictors of ischemia in our patient population. Conclusions: This study showed that BMI was an independent predictor of ischemia in our patient population.

show abstract

Section: Discussionmentioning

confidence: 99%

Body Mass Index Is Independently Associated with the Presence of Ischemia in Myocardial Perfusion Imaging

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The Framingham Heart Study reported increased mortality and morbidity due to coronary heart disease in subjects with highly variable body weights [ 12 ]. In a Korean nationwide cohort study, high variabilities in body weight were associated with higher risks of cardiovascular disease and all-cause mortality [ 22 ]. We provided evidence that weight cycling was associated with the development of diabetes [ 23 ], and the findings of the present study are in line with the results of previous studies.…”

Section: Discussionmentioning

confidence: 99%

Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability

Jung

Koo²,

Lee

et al. 2021

Endocrinol Metab

View full text Add to dashboard Cite

Background: Weight loss through lifestyle modification is recommended for patients with nonalcoholic fatty liver disease (NAFLD). Recent studies have suggested that repeated loss and gain of weight is associated with worse health outcomes. This study aimed to examine the association between weight variability and the risk of NAFLD in patients without diabetes.Methods: We examined the health-checkup data of 30,708 participants who had undergone serial examinations between 2010 and 2014. Weight variability was assessed using coefficient of variation and the average successive variability of weight (ASVW), which was defined as the sum of absolute weight changes between successive years over the 5-year period divided by 4. The participants were classified according to the baseline body mass index and weight difference over 4 years.Results: On dividing the participants into four groups according to ASVW quartile groups, those in the highest quartile showed a significantly increased risk of NAFLD compared to those in the lowest quartile (odds ratio [OR], 1.89; 95% confidence interval [CI], 1.63 to 2.19). Among participants without obesity at baseline, individuals with high ASVW showed increased risk of NAFLD (OR, 1.80; 95% CI, 1.61 to 2.01). Participants with increased weight over 4 years and high ASVW demonstrated higher risk of NAFLD compared to those with stable weight and low ASVW (OR, 4.87; 95% CI, 4.29 to 5.53).Conclusion: Regardless of participant baseline obesity status, high weight variability was associated with an increased risk of developing NAFLD. Our results suggest that further effort is required to minimize weight fluctuations after achieving a desirable body weight.

show abstract

“…The uncorrected VIM was corrected using this formula: (VIM uncorrected×mean of CV)/mean of VIM uncorrected [ 26 ]. Because the results from all variability measures were similar (with exception of the results between variability measures and the relationship with retinopathy in our primary analysis), the corrected variability independent of the mean (cVIM) was used as the primary variability measure in this study whiles results from the other variability measures are reported for comparative purposes [ 16 , 27 , 28 ].…”

Section: Methodsmentioning

confidence: 99%

Waist Circumference and Body Mass Index Variability and Incident Diabetic Microvascular Complications: A Post Hoc Analysis of ACCORD Trial

Hukportie¹,

Li²,

Zhou³

et al. 2022

Diabetes Metab J

View full text Add to dashboard Cite

Background: Obesity is associated with adverse health events among diabetic patients, however, the relationship between obesity fluctuation and risk of microvascular complications among this specific population is unclear. We aimed to examine the effect of waist circumference (WC) and body mass index (BMI) variability on the risk of diabetic microvascular outcomeMethods: Annually recorded anthropometric data in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study was used to examine the association of WC and BMI variability defined as variability independent of mean, with the risk of microvascular outcomes, including neuropathy, nephropathy, and retinopathy. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) (Trial registration: ClinicalTrials.gov., no. NCT00000620).Results: There were 4,031, 5,369, and 2,601 cases of neuropathy, nephropathy, and retinopathy during a follow-up period of 22,524, 23,941, and 23,850 person-years, respectively. Higher levels of WC and BMI variability were associated with an increased risk of neuropathy. Compared with the lowest quartile, the fully-adjusted HR (95% CI) for the highest quartile of WC and BMI variability for neuropathy risk were 1.21 (1.05 to 1.40) and 1.16 (1.00 to 1.33), respectively. Also, higher quartiles of BMI variability but not WC variability were associated with increased risk of nephropathic events. The fully-adjusted HR (95% CI) for the highest quartile compared with the lowest quartile of BMI variability was 1.31 (1.18 to 1.46). However, the results for retinopathic events were all insignificant.Conclusion: Among participants with type 2 diabetes mellitus, WC and BMI variability were associated with a higher risk of neuropathic events, whereas BMI variability was associated with an increased risk of nephropathic events.

show abstract

Variabilities in Weight and Waist Circumference and Risk of Myocardial Infarction, Stroke, and Mortality: A Nationwide Cohort Study

Cited by 17 publications

References 30 publications

Body Mass Index Is Independently Associated with the Presence of Ischemia in Myocardial Perfusion Imaging

Body Mass Index Is Independently Associated with the Presence of Ischemia in Myocardial Perfusion Imaging

Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability

Waist Circumference and Body Mass Index Variability and Incident Diabetic Microvascular Complications: A Post Hoc Analysis of ACCORD Trial

Contact Info

Product

Resources

About