Vapor, Dust, and Smoke Exposure in Relation to Adult-Onset Asthma and Chronic Respiratory Symptoms

LeVan, Tricia D.; Koh, Woon Puay; Lee, Hin Peng; Koh, David; Yu, Mimi C.; London, Stephanie J.

doi:10.1093/aje/kwj144

Cited by 75 publications

(68 citation statements)

References 52 publications

(48 reference statements)

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“…It has previously been shown that exposure to VGDF is associated with cough and wheeze as well as both asthma and rhinitis [4,8–10]. Also our findings support this; VGDF-exposure was significantly associated to all symptoms and diseases, and the results were almost identical when the analyses were performed in non-smokers only.…”

Section: Discussionsupporting

confidence: 90%

Job titles classified into socioeconomic and occupational groups identify subjects with increased risk for respiratory symptoms independent of occupational exposure to vapour, gas, dust, or fumes

Schyllert

Andersson

Hedman

et al. 2018

European Clinical Respiratory Journal

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Objectives: To evaluate the ability of three different job title classification systems to identify subjects at risk for respiratory symptoms and asthma by also taking the effect of exposure to vapours, gas, dust, and fumes (VGDF) into account. Background: Respiratory symptoms and asthma may be caused by occupational factors. There are different ways to classify occupational exposure. In this study, self-reported occupational exposure to vapours, gas, dust and fumes was used as well as job titles classifed into occupational and socioeconomic Groups according to three different systems. Design: This was a large population-based study of adults aged 30–69 years in Northern Sweden (n = 9,992, 50% women). Information on job titles, VGDF-exposure, smoking habits, asthma and respiratory symptoms was collected by a postal survey. Job titles were used for classification into socioeconomic and occupational groups based on three classification systems; Socioeconomic classification (SEI), the Nordic Occupations Classification 1983 (NYK), and the Swedish Standard Classification of Occupations 2012 (SSYK). Associations were analysed by multivariable logistic regression. Results: Occupational exposure to VGDF was a risk factor for all respiratory symptoms and asthma (odds ratios (ORs) 1.3–2.4). Productive cough was associated with the socioeconomic groups of manual workers (ORs 1.5–2.1) and non-manual employees (ORs 1.6–1.9). These groups include occupations such as construction and transportation workers, service workers, nurses, teachers and administration clerks which by the SSYK classification were associated with productive cough (ORs 2.4–3.7). Recurrent wheeze was significantly associated with the SEI group manual workers (ORs 1.5–1.7). After adjustment for also VGDF, productive cough remained significantly associated with the SEI groups manual workers in service and non-manual employees, and the SSYK-occupational groups administration, service, and elementary occupations. Conclusions: In this cross-sectional study, two of the three different classification systems, SSYK and SEI gave similar results and identified groups with increased risk for respiratory symptoms while NYK did not give conclusive results. Furthermore, several associations were independent of exposure to VGDF indicating that also other job-related factors than VGDF are of importance.

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Section: Discussionsupporting

confidence: 90%

Job titles classified into socioeconomic and occupational groups identify subjects with increased risk for respiratory symptoms independent of occupational exposure to vapour, gas, dust, or fumes

Schyllert

Andersson

Hedman

et al. 2018

European Clinical Respiratory Journal

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“…This study showed that occupational exposure to pesticides was associated with the onset of asthma in adulthood (OR 1.69, 95% CI 1.13-2.52] [49].…”

Section: Studies In Adultsmentioning

confidence: 82%

“…Only three authors found a link between environmental exposure to pesticides and respiratory symptoms, but this association was not very significant [45,48,49]. A multivariate analysis showed that the symptoms reported by the subjects were significantly associated with the perception of certain odours or periods of employment under conditions of environmental exposure, despite the fact that biological monitoring had not provided evidence of higher exposure to malathion, DDT or other chlorinated compounds [44].…”

Section: Discussionmentioning

confidence: 97%

Environmental exposure to pesticides and respiratory health

et al. 2015

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Respiratory effects of environmental exposure to pesticides are debated. Here we aimed to review epidemiological studies published up until 2013, using the PubMed database. 20 studies dealing with respiratory health and non-occupational pesticide exposure were identified, 14 carried out on children and six on adults.In four out of nine studies in children with biological measurements, mothers' dichlorodiphenyldichloroethylene (DDE) blood levels during pregnancy were associated with asthma and wheezing in young children. An association was also found between permethrin in indoor air during pregnancy and wheezing in children. A significant association between asthma and DDE measured in children's blood (aged 7-10 years) was observed in one study. However, in three studies, no association was found between asthma or respiratory infections in children and pesticide levels in breast milk and/or infant blood. Lastly, in three out of four studies where post-natal pesticide exposure of children was assessed by parental questionnaire an association with respiratory symptoms was found. Results of the fewer studies on pesticide environmental exposure and respiratory health of adults were much less conclusive: indeed, the associations observed were weak and often not significant.In conclusion, further studies are needed to confirm whether there is a respiratory risk associated with environmental exposure to pesticides. @ERSpublications Occupational pesticide exposure increases respiratory health risk but data are unclear for environmental exposures http://ow.ly/PSGvz

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“…These adverse health effects range from irritancy to serious respiratory diseases, including chronic obstructive airway disease and lung cancer. Some types of effects reported to be associated with wood smoke are not unlike those of mixed, urban ambient PM for both cancer and non-cancer endpoints (Mishra et al, 2004;LeVan et al, 2006;Gerlofs-Nijland et al, 2007). The Risk Assessment breakout session considered three important future research questions: (1) Are there effects (perhaps irritancy under certain exposure conditions?)…”

Section: Hazard Identificationmentioning

confidence: 99%

Wood smoke risk assessment: Defining the questions

Morandi

Ward

2009

Inhalation Toxicology

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Risk assessment provides a framework for combining and evaluating scientific data on source-to-health effects for contaminants that could potentially affect the health of human populations. It utilizes an integrated approach to hazard identification, dose response, exposure assessment, and risk characterization. Since the range of potential exposure scenarios is considerable, given the complexity of wood-smoke sources and emissions, there is a need for defining the critical characteristics for the key parameters leading to adverse health outcomes. During the International Biomass Smoke and Health Effects (IBSHE) conference at the University of Montana (August 2007), the breakout group entitled "Risk Assessment: Defining the Questions" was tasked with evaluating the current state of the science in regard to risk assessment involving biomass smoke exposure. As a result of these discussions, important data gaps and future research questions were identified that are reported in this article.

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Vapor, Dust, and Smoke Exposure in Relation to Adult-Onset Asthma and Chronic Respiratory Symptoms

Cited by 75 publications

References 52 publications

Job titles classified into socioeconomic and occupational groups identify subjects with increased risk for respiratory symptoms independent of occupational exposure to vapour, gas, dust, or fumes

Job titles classified into socioeconomic and occupational groups identify subjects with increased risk for respiratory symptoms independent of occupational exposure to vapour, gas, dust, or fumes

Environmental exposure to pesticides and respiratory health

Wood smoke risk assessment: Defining the questions

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