Environmental exposure to pesticides and respiratory health

Mamane, Ali; Rahérison, Chantal; Tessier, J.F.; Baldi, Isabelle; Bouvier, Ghislaine

doi:10.1183/16000617.00006114

Cited by 69 publications

(52 citation statements)

References 43 publications

(75 reference statements)

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“…The high‐intensity use of organophosphate (OP) pesticides has contributed to morbidity and mortality in farmworkers and their families through acute or chronic pesticide‐related illnesses . Recently, the long‐term effects of pesticide exposure have been associated with many diseases . The Phytoner study reported an association between chronic exposure to pesticides and cognitive impairment .…”

Section: Introductionmentioning

confidence: 99%

Mechanism underlying the effect of long‐term exposure to low dose of pesticides on DNA integrity

Alleva

Manzella

Gaetani

et al. 2018

Environmental Toxicology

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Pesticides, including herbicides, insecticides and fungicides, are widely used in intensive agriculture. Recently, the long-term effects of pesticide exposure were found to be associated with many diseases. In this study, we evaluated the long-term effect of low-level exposure to a mixture of pesticides on DNA damage response (DDR) in relation to individual detoxifying variability. A residential population chronically exposed to pesticides was enrolled, biological/environmental pesticide levels; paroxonase 1 (PON-1) activity and 192 Q/R polymorphism and DDR were evaluated at three different periods of pesticide exposure. OGG1-dependent DNA repair activity was decreased in relation to pesticide exposure. The increase of DNA lesions and pesticide levels in the intensive pesticide-spraying period was independent on PON-1 activity. Next, human bronchial epithelial and neuronal cells were used as a model for in vitro evaluation of the mechanistic effect of pesticides. Pesticides induced mitochondrial dysfunction leading to ROS formation. ROS from mitochondria induced DNA damage, which in turn induced OGG1-dependent DNA repair activity through 8-oxoguanine DNA glycosylase 1 (OGG1) expression and activation. Even though OGG1 was overexpressed, an inhibition of its activity, associated with DNA lesion accumulation, was found at prolonged pesticide-exposure. A post-translational regulation of OGG1 by pesticide may be postulated. Taken together, long-term exposure to low-levels of pesticides affects DDR resulting in accumulation of DNA lesions that eventually may lead to cancer or neurological disorders.

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Section: Introductionmentioning

confidence: 99%

Mechanism underlying the effect of long‐term exposure to low dose of pesticides on DNA integrity

Alleva

Manzella

Gaetani

et al. 2018

Environmental Toxicology

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“…This was supported by several pieces of evidence, including those suggesting that PAHs are formed mainly by organic fuel combustion and released into the atmosphere (Baek et al, 1991), where they can contribute to risk factors for respiratory cancer and childhood asthma (Bosetti et al, 2007;Karimi et al, 2015;Rota et al, 2014). A meta-analysis study concluded that the relationship between pesticide exposure and respiratory health is controversial (Mamane et al, 2015), and several other studies suggest that occupational exposure to pesticides increases the risks of developing asthma (Fareed et al, 2013;Ye et al, 2013). However, there is little epidemiological evidence to support the relationship between PFC exposure and asthma in humans (Dong et al, 2013), although a study in mice indicated a possible association (Fairley et al, 2007).…”

Section: Discussionmentioning

confidence: 95%

A network biology-based approach to evaluating the effect of environmental contaminants on human interactome and diseases

Iida

Takemoto

2018

Ecotoxicology and Environmental Safety

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Environmental contaminant exposure can pose significant risks to human health. Therefore, evaluating the impact of this exposure is of great importance; however, it is often difficult because both the molecular mechanism of disease and the mode of action of the contaminants are complex. We used network biology techniques to quantitatively assess the impact of environmental contaminants on the human interactome and diseases with a particular focus on seven major contaminant categories: persistent organic pollutants (POPs), dioxins, polycyclic aromatic hydrocarbons (PAHs), pesticides, perfluorochemicals (PFCs), metals, and pharmaceutical and personal care products (PPCPs). We integrated publicly available data on toxicogenomics, the diseasome, protein-protein interactions (PPIs), and gene essentiality and found that a few contaminants were targeted to many genes, and a few genes were targeted by many contaminants. The contaminant targets were hub proteins in the human PPI network, whereas the target proteins in most categories did not contain abundant essential proteins. Generally, contaminant targets and disease-associated proteins were closely associated with the PPI network, and the closeness of the associations depended on the disease type and chemical category. Network biology techniques were used to identify environmental contaminants with broad effects on the human interactome and contaminant-sensitive biomarkers. Moreover, this method enabled us to quantify the relationship between environmental contaminants and human diseases, which was supported by epidemiological and experimental evidence. These methods and findings have facilitated the elucidation of the complex relationship between environmental exposure and adverse health outcomes.

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“…The pesticide exposure of farmers' families, especially children, can be potentially significant as there is a combination of para-occupational, environmental and domestic exposures (Silvério et al, 2017). Residential exposure depends on proximity of the house to areas treated with pesticides, the persistence of pesticides used in or around the home and domestic uses at home on pets (flies and ticks) and also on humans (lice and scabies) (Bouvier et al, 2005;Mamane et al, 2015). Direct exposure to pesticides can occur during the application whereas indirect exposure of farm spouses and children to pesticides can occur through spray drift, transfer of contaminated dust and soil from treated fields to farm vehicles and buildings.…”

Section: Introductionmentioning

confidence: 99%

“…Key words: Environmental pesticides 'exposure, Adolescent females, AChE ,Menstrual and Neurobehavioral disorders. such as endocrine disruption, blood and neurobehavioral disorders as well as the possibility of an increased risk of cancer especially, childhood cancers such as Non-Hodgkin lymphoma and leukemia (Clayton et al, 2003;Mamane et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Neurobehavioral and Menstrual Disorders among Adolescent Females Environmentally Exposed to Pesticides, Menoufia Governorate, Egypt

Rasoul¹,

Salem²,

Elbadry³

et al. 2019

Egypt. J. Occup. Med.

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Introduction: Adolescent females living in agricultural areas where crops are routinely sprayed by pesticides are expected to be environmentally exposed to pesticidesˊ health hazards partially as those occupationally exposed. Aim of work: to assess neurobehavioral and menstrual disorders among adolescent females environmentally exposed to pesticides. Materials and methods: This was a cross-sectional study conducted on 100 pesticide exposed adolescent females who had one or more of family members are pesticidesˊ seasonal applicators and 50 non-exposed adolescent females matched for age and education, served as controls at Menoufia governorate, Egypt; during the period of pesticide application season of cotton crop from the first of May to the end of September 2017. A self-administered questionnaire and a series of neurobehavioral tests were administered and serum acetyl cholinesterase (AChE) activity was assessed. Results: A significant lower AChE activity levels were detected among the exposed group compared to the controls (Mean±SD=238.49± 23.83 vs 303.35±78.54 IU/L; respectively). There were significant higher mean scores of trail making test (parts 1 and 2) and significant lower mean scores of (similarities test, Benton visual retention test, block design test, Santa Ana dexterity test (dominant and non-dominant hands) and Beery visuo-motor imitation test among the exposed group compared to the controls (P<0.05). Also, the exposed group reported more prevalent irregular menstrual cycle (26.8%) and intermenstrual bleeding (28.2%) compared to the control participants (8.1% and 8.1%; respectively). Conclusion and recommendations: Adolescent females living in agricultural areas and from families whose one or more members are pesticidesˊ applicators had significantly lower neurobehavioral performance, report more prevalent menstrual irregularities and have lower levels of serum AChE compared to the control group. The neurobehavioral deficits demonstrated a dose-response relationship with AChE levels

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Environmental exposure to pesticides and respiratory health

Cited by 69 publications

References 43 publications

Mechanism underlying the effect of long‐term exposure to low dose of pesticides on DNA integrity

Mechanism underlying the effect of long‐term exposure to low dose of pesticides on DNA integrity

A network biology-based approach to evaluating the effect of environmental contaminants on human interactome and diseases

Neurobehavioral and Menstrual Disorders among Adolescent Females Environmentally Exposed to Pesticides, Menoufia Governorate, Egypt

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