Vapor delivery of plant essential oils alters pyrethroid efficacy and detoxification enzyme activity in mosquitoes

O’Neal, Scott T.; Johnson, Ellis J.; Rault, Leslie C.; Anderson, Troy D.

doi:10.1016/j.pestbp.2019.03.007

Cited by 33 publications

(16 citation statements)

References 32 publications

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“…We decided to perform the second variant of the experiment and avoid blending used chemicals, which resulted in a massive increase of larvae lethality, proving the potentiation—the effect when non-lethal substance increases lethality of a toxic compound. A similar strategy was used on a mosquito ( Aedes aegypti ) with 4 h exposition on essential oils vapors before deltamethrin topical application, which also resulted in toxicity growth [ 56 ]. The effects prove that the strategy of application may significantly affect results of the agrochemical strategies.…”

Section: Resultsmentioning

confidence: 99%

Solanum nigrum Fruit Extract Increases Toxicity of Fenitrothion—A Synthetic Insecticide, in the Mealworm Beetle Tenebrio molitor Larvae

Spochacz

Szymczak

Chowański

et al. 2020

Toxins

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Synthetic insecticides are widely used for crop protection both in the fields and in the food stored facilities. Due to their toxicity, and assumptions of Integrated Pest Management, we conducted two independent experiments, where we studied the influence of Solanum nigrum unripe fruit extract on the toxicity of an organophosphorus insecticide fenitrothion. In the first variant of the experiment, Tenebrio molitor larvae were fed with blended fenitrothion (LC50) and the extract in four concentrations (0.01, 0.1, 1 and 10%) in ratio 1:1 for 3 days. In the second variant, a two-day application of fenitrothion (LC40) was preceded by a one-day extract treatment. The first variant did not show any increase in lethality compared to fenitrothion; however, ultrastructure observations exhibited swollen endoplasmic reticulum (ER) membranes in the midgut and nuclear and cellular membranes in the fat body, after application of blended fenitrothion and extract. An increased amount of heterochromatin in the fat body was observed, too. In the second variant, pre-treatment of the extract increased the lethality of larvae, decreased the level of glycogen and lipids in the fat body and disrupted integrity of midgut cellular membranes. S. nigrum extract, applied prior to fenitrothion treatment can be a factor increasing fenitrothion toxicity in T. molitor larvae. Thus, this strategy may lead to decreased emission of synthetic insecticides to the environment.

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Section: Resultsmentioning

confidence: 99%

Solanum nigrum Fruit Extract Increases Toxicity of Fenitrothion—A Synthetic Insecticide, in the Mealworm Beetle Tenebrio molitor Larvae

Spochacz

Szymczak

Chowański

et al. 2020

Toxins

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“…Since essential oil components are volatile and exhibit vapor toxicity against various urban and agricultural insect pests [12,20,46], the effects of monoterpenoid mixtures on their vapor toxicity levels need to be determined in the future. Lastly, an increasing body of literature suggests that plant essential oils containing monoterpenoids inhibit cytochrome P450s in different mosquito species [47][48][49]. Thus, increased inhibition of detoxification enzymes by monoterpenoid mixtures could be yet another mechanism of synergism.…”

Section: Bifenthrinmentioning

confidence: 99%

“…Additionally, in pesticide-susceptible and resistant American cockroaches and mosquitoes, essential oils were shown to potentially synergize the toxicity of pyrethroid and carbamate insecticides. either by inhibiting P450 enzymes or by activating neurological target sites [48,49,57]. Therefore, future research should also explore the possibility of using monoterpenoids or essential oils as synergists for overcoming resistance to pyrethroids and other insecticides in bed bugs.…”

Section: Implications For Natural Product Development and Bed Bug Manmentioning

confidence: 99%

Synergistic Toxicity Interactions between Plant Essential Oil Components against the Common Bed Bug (Cimex lectularius L.)

Gaire

Scharf

Gondhalekar

2020

Insects

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Management of the common bed bug (Cimex lectularius L.) necessitates the use of multiple control techniques. In addition to synthetic pesticides and mechanical interventions, plant-derived essential oils represent one of the control options. Mixtures of two or more essential oil components (monoterpenoids) exhibit synergistic toxicity effects against insects due to increased cuticular penetration. Monoterpenoids, such as carvacrol, eugenol and thymol, are neurologically active and inhibit the nerve firing activity of C. lectularius. However, the effects of mixtures of these monoterpenoids on their toxicity and neuroinhibitory potential against C. lectularius are not known. In this study, the toxicity levels of a tertiary mixture of carvacrol, eugenol and thymol (1:1:1 ratio) and a binary mixture of synthetic insecticides, bifenthrin and imidacloprid (1:1 ratio) were evaluated against C. lectularius through topical bioassays and electrophysiology experiments. Both a mixture of monoterpenoids and the mixture of synthetic insecticides exhibited synergistic effects in topical bioassays. In electrophysiology experiments, the monoterpenoid mixture led to greater neuroinhibitory effects, whereas a mixture of synthetic insecticides caused higher neuroexcitatory effects in comparison to single compounds. This study shows evidence for neurological mechanisms of synergistic interactions between monoterpenoids and provides information regarding the utilization of natural compound mixtures for C. lectularius management.

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“…However, nano formulations of essential oils that exhibit reduced volatility and thereby prolong their residual life may promote the development and use of more effective essential oil formulations in the near future. A growing body of literature on agricultural, urban, and public health insect pests suggest that plant essential oils can be potentially used as synergists (similar to piperonyl butoxide or PBO) for enhancing the efficacy of pyrethroid insecticides particularly against resistant populations of various insect pests [84][85][86][87]. This phenomenon of pyrethroid toxicity enhancement by essential oils needs to be explored in resistant German cockroaches and offers opportunities for utilizing natural products in IPM.…”

Section: Emerging Technologies For German Cockroach Controlmentioning

confidence: 99%

A Review of Alternative Management Tactics Employed for the Control of Various Cockroach Species (Order: Blattodea) in the USA

Gondhalekar

Appel

Thomas

et al. 2021

Insects

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Effective control of domestic and peridomestic cockroaches requires integrated approaches that emphasize concurrent use of chemicals with alternative control tactics. An integrated pest management (IPM) approach is particularly justified in environments where satisfactory cockroach control cannot be achieved due to multiple factors including development of insecticide aversion and resistance in some cockroach species, and poor sanitation or structural issues that foster infestations. While a flurry of research effort has been devoted to study alternative tactics for cockroach control, only a few of them have been evaluated in the context of IPM programs. This review focuses on examining studies on alternative tactics that are proven efficacious, economical, and logistically feasible for their inclusion in IPM programs for important domestic and peridomestic cockroaches in the USA. Management programs that educate the public on cockroach biology, behavior, and the importance of sanitation; use of traps to monitor infestation levels; apply targeted low impact insecticides such as baits, have demonstrated a greater success for effective and sustainable control of cockroaches when compared to an insecticide-only approach. Incorporation of other alternative control methods to IPM programs will require more applied research that validates their use in real-world scenarios and demonstrates their cost-effectiveness.

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Vapor delivery of plant essential oils alters pyrethroid efficacy and detoxification enzyme activity in mosquitoes

Cited by 33 publications

References 32 publications

Solanum nigrum Fruit Extract Increases Toxicity of Fenitrothion—A Synthetic Insecticide, in the Mealworm Beetle Tenebrio molitor Larvae

Solanum nigrum Fruit Extract Increases Toxicity of Fenitrothion—A Synthetic Insecticide, in the Mealworm Beetle Tenebrio molitor Larvae

Synergistic Toxicity Interactions between Plant Essential Oil Components against the Common Bed Bug (Cimex lectularius L.)

A Review of Alternative Management Tactics Employed for the Control of Various Cockroach Species (Order: Blattodea) in the USA

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