Vapor-based tri-functional coatings

Chen, Hsien‐Yeh; Lin, Tyrone T.; Tsai, Meng-Shiun; Su, Chiao-Tzu; Yuan, Ruei-Hung; Hsieh, Chia Chien; Yang, Yao-Jhen; Hsu, Chin-Hsien; Hsiao, Hao‐Ming; Hsu, Yin-Chu

doi:10.1039/c3cc41491d

Cited by 34 publications

(34 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Theoretically, three (or more) sourced depositions and copolymerizations can be realized. 33 The deposition to form a poly[4- N -hydroxysuccinimide-ester- p -xylylene- co -4-methyl-propiolate- p -xylylene- co - p -xylylene] copolymer on the sublimating Fe 3 O 4 /ice particles can produce the analogous Fe 3 O 4 /poly- para -xylylene particle composites and composites with installed functional groups, such as NHS-ester and ester-alkyne groups, which are accessible to the amine/NHS−ester coupling reaction 34 and the azide-alkyne cycloaddition reaction without the requirement of a copper catalyst. 32 , 35 The use of the multifunctional poly- para -xylylene copolymer additionally provided the featured function of (iii) for the proposed, multifunctional poly- para -xylylene particle composites.…”

Section: Resultsmentioning

confidence: 99%

Vapor sublimation and deposition to build porous particles and composites

et al. 2018

Self Cite

View full text Add to dashboard Cite

The vapor deposition of polymers on regular stationary substrates is widely known to form uniform thin films. Here we report porous polymer particles with sizes controllable down to the nanometer scale can be produced using a fabrication process based on chemical vapor deposition (CVD) on a dynamic substrate, i.e., sublimating ice particles. The results indicate that the vapor deposition of a polymer is directed by the sublimation process; instead of forming a thin film polymer, the deposited polymers replicated the size and shape of the ice particle. Defined size and porosity of the polymer particles are controllable with respect to varying the processing time. Extendable applications are shown to install multiple functional sites on the particles in one step and to localize metals/oxides forming composite particles. In addition, one fabrication cycle requires approximately 60 min to complete, and potential scaling up the production of the porous particles is manageable.

show abstract

Section: Resultsmentioning

confidence: 99%

Vapor sublimation and deposition to build porous particles and composites

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…[8,5,9] The presence of substituents such as aldehyde, ketone, alcohol, ester,a mine, as well as fluorinated groups, thiol reactive groups,A TRP initiator groups, photosensitiveo ra lkynyl groups in the precursor and consequently in the polymer coatingh as enabled variousp ost-modification strategies. [2,[10][11][12][13][14][15][16][17][18][19][20][21][22][23] Attachmento fp roteins, short peptides, nucleotides, and other smallb iologically activem olecules onto this functional coating can dramatically influence the response of adherent cells. [10,11,13,19] Therefore, precise design of surface chemistry provided by CVD enables the control of cell behavior by tailoringi nteractions between CVD coatings and living organisms.…”

Section: Introductionmentioning

confidence: 99%

“…FDA‐approved in some instances, poly‐ p ‐xylylene‐based coatings have been prepared by CVD polymerization of [2.2]paracyclophane derivatives for surface modification and structuring of a wide range of materials . The presence of substituents such as aldehyde, ketone, alcohol, ester, amine, as well as fluorinated groups, thiol reactive groups, ATRP initiator groups, photo‐sensitive or alkynyl groups in the precursor and consequently in the polymer coating has enabled various post‐modification strategies . Attachment of proteins, short peptides, nucleotides, and other small biologically active molecules onto this functional coating can dramatically influence the response of adherent cells .…”

Section: Introductionmentioning

confidence: 99%

Polylutidines: Multifunctional Surfaces through Vapor‐Based Polymerization of Substituted Pyridinophanes

Gall

Hussal

Kramer

et al. 2017

Chemistry A European J

View full text Add to dashboard Cite

We report a new class of functionalized polylutidine polymers that are prepared by chemical vapor deposition polymerization of substituted [2](1,4)benzeno[2](2,5)pyridinophanes. To prepare sufficient amounts of monomer for CVD polymerization, a new synthesis route for ethynylpyridinophane has been developed in three steps with an overall yield of 59 %. Subsequent CVD polymerization yielded well-defined films of poly(2,5-lutidinylene-co-p-xylylene) and poly(4-ethynyl-2,5-lutidinylene-co-p-xylylene). All polymers were characterized by infrared reflection-absorption spectroscopy, ellipsometry, contact angle studies, and X-ray photoelectron spectroscopy. Moreover, ζ-potential measurements revealed that polylutidine films have higher isoelectric points than the corresponding poly-xylylene surfaces owing to the nitrogen atoms in the polymer backbone. The availability of reactive alkyne groups on the surface of poly(4-ethynyl-2,5-lutidinylene-co-p-xylylene) coatings was confirmed by spatially controlled surface modification by means of Huisgen 1,3-dipolar cycloaddition. Compared to the more hydrophobic poly-p-xylylyenes, the presence of the heteroatom in the polymer backbone of polylutidine polymers resulted in surfaces that supported an increased adhesion of primary human umbilical vein endothelial cells (HUVECs). Vapor-based polylutidine coatings are a new class of polymers that feature increased hydrophilicity and increased cell adhesion without limiting the flexibility in selecting appropriate functional side groups.

show abstract

“…In the present study, we synthesized a multicomponent coating, poly[( N ‐hydroxysuccinimide ester‐ p ‐xylylene)‐ co ‐(benzoyl‐ p ‐xylylene)‐ co ‐( p ‐xylylene)] (hereafter referred to as PPX‐d‐NB; ‐d‐ indicates disubstitution), which comprised N ‐hydroxysuccinimide ester (NHS ester) and benzoyl functional moieties, and the resulting coating surface was readily available for the concurrent conjugation of biomolecules via NHS ester‐amine coupling (through the NHS ester motif) and light‐induced molecular crosslinking via rapid insertion into CH or NH bonds (through the benzoyl motif). Synthesis of the multicomponent coating was based on a one‐step coating process that exploited chemical vapor deposition (CVD) copolymerization, which renders a conformal and substrate‐independent coating . The coating technology can be transferred from one substrate to another and can be modified on a substrate irrespective of the shape, e.g., on a microsphere, a curved liquid surface, or the inner surface of a confined microchannel .…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Surface Modification: Facile and Flexible Reactivity toward a Precisely Controlled Biointerface

Yuan

Tung

et al. 2016

Macromolecular Bioscience

Self Cite

View full text Add to dashboard Cite

A multicomponent functional polymer is synthesized to support specific reactivity for successful conjugation with the vast array of functionality present in biological systems and the flexibility to conjugate biomolecules without requiring additional modification to install a terminal functional group. The multifunctional surface is realized using a novel coating composed of distinct N-hydroxysuccinimide (NHS) ester and benzoyl functionalities, which can provide accessibility to both the NHS ester-amine coupling reaction and the photochemically induced benzophenone crosslinking reaction, respectively. In addition, the multifunctional polymer is fabricated and transformed to form nanoscale colloids through the solvent displacement of a water/DMF system due to solubility characteristics of the resulting polymer with high polarity. A facile and efficient fabrication approach using the multifunctional nanocolloid is thus demonstrated to create a drug carrier by installing paclitaxel and folic acid for targeted cancer therapy.

show abstract

Vapor-based tri-functional coatings

Cited by 34 publications

References 21 publications

Vapor sublimation and deposition to build porous particles and composites

Vapor sublimation and deposition to build porous particles and composites

Polylutidines: Multifunctional Surfaces through Vapor‐Based Polymerization of Substituted Pyridinophanes

Multifunctional Surface Modification: Facile and Flexible Reactivity toward a Precisely Controlled Biointerface

Contact Info

Product

Resources

About