Vannilic acid ameliorates hyperglycemia-induced oxidative stress and inflammation in streptozotocin-induced diabetic rats

Ji, Guoxin; Sun, Rong; Hu, Haiyan; Xu, Fengqin; Yu, Xinjuan; Veeraraghavan, Vishnu Priya; Mohan, Surapaneni Krishna; Chi, Xiaoyan

doi:10.1016/j.jksus.2020.04.010

Cited by 16 publications

(16 citation statements)

References 31 publications

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“…Our data revealed a substantial increase in the level of ALT and AST in diabetic rats, similar to other studies (51,52). In line with our findings, they reported a significant reduction in ALT and AST levels after oral supplementation with LC (53).…”

Section: Discussionsupporting

confidence: 93%

L-carnitine Attenuates DNA Damage and Oxidative Stress in Diabetic Animals

Kanani

Etebari

2022

Int J Cancer Manag

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Background: Diabetes is a metabolic disorder characterized by high plasma glucose levels. In this disease, increased production of reactive oxygen species (ROS) results in DNA damage and multiple complications. L-carnitine (LC) has shown a potent antioxidant activity that may reduce oxidative stress. Objectives: This study aims at assaying the effect of LC on DNA damage in streptozotocin-induced diabetic rats and evaluating the changes in antioxidant markers and liver function enzymes after the administration of LC . Methods: In the present study, for induction of diabetes, we injected a single dose of streptozotocin (65 mg/kg) by the intraperitoneal route, and diabetic rats were treated with LC 200, 300, and 400 mg/kg daily for 3 weeks. We detected the DNA damage at 7, 14, and 21 days after induction diabetes by the comet assay method. The blood glucose level, plasma alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were tested. Also, we measured the activity levels of superoxide dismutase (SOD) and intracellular glutathione (GSH). Results: The results of this study demonstrated the increasing amount of DNA damage with the amount and duration of hyperglycemia. L-carnitine treatment significantly decreased the parameters of genotoxicity such as % DNA in the tail, tail length, and tail moment over time. Moreover, the treatment of diabetic rats with LC 300 and 400 mg/kg/day after 21 days led to a remarkable decrease in blood glucose than diabetic rats. Also, we observed that LC can ameliorate enzyme liver function and reduce oxidative stress via enhancement of GSH and SOD levels. Conclusions: The results of this study indicated the protective effect of LC against DNA damage and oxidative stress in diabetic rats.

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Section: Discussionsupporting

confidence: 93%

L-carnitine Attenuates DNA Damage and Oxidative Stress in Diabetic Animals

Kanani

Etebari

2022

Int J Cancer Manag

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“…It is originating primarily from the hippocampus and amygdala. Since the hippocampus is the main structure involved in learning and memory, damage to this structure often results in cognitive impairment ( Ji et al, 2020 , Wang et al, 2020b ). Neuroimaging studies show that hippocampal atrophy, neuronal cell loss in the hippocampus, and decreased neuronal density in the dentate gyrus positively correlate with memory impairment in patients with TLE.…”

Section: Introductionmentioning

confidence: 99%

Wogonin preventive impact on hippocampal neurodegeneration, inflammation and cognitive defects in temporal lobe epilepsy

Guo

Wang

et al. 2020

Saudi Journal of Biological Sciences

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Previous studies demonstrated that the pathophysiological changes after temporal lobe epilepsy (TLE) such as oxidative stress, inflammatory reaction contribute to cognitive defect and neuronal damage. The present study was conducted to evaluate the anticonvulsant effect of wogonin ameliorates kainate-induced TLE, and to investigate the mechanism underlying these effects. Rats were divided into control, wogonin, kainate, and wogonin-pretreated kainate groups. The rat model of TLE was induced by unilateral intrahippocampal injection of 0.4 ug/ul of kainate. The results showed that the cognitive function in TLE rats was significantly impaired, and wogonin treatment improved cognitive function in the Morris water maze (MWM). H & E staining and TUNEL staining showed obvious damage in the hippocampus of TLE rats, and wogonin alleviated the damage. To evaluate the oxidative stress, the expression of MDA and GSH in plasma were detected. Nrf-2 and HO-1 mRNA expression in the hippocampus were detected. The levels of MDA in plasma increased in TLE rats, and the levels of GSH in plasma and Nrf-2, HO-1 in the brain decreased. Treatment with wogonin alleviated these changes. We also detected the mRNA expression of inflammatory mediators like IL-1β, TNF-α, and NF kB in the brain. The inflammatory reaction was significantly activated in the brain of TLE rats, and wogonin alleviated neuroinflammation. We detected the mRNA expression of Bcl-2, Bax, caspase-3, in the hippocampus. The levels of Bcl-2 decreased in TLE rats, Bax and caspase-3 increased, while wogonin alleviated these changes. The present study indicated that wogonin exerted a noticeable neuroprotective effect in kainate-induced TLE rats.

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“…Administration of vanillic acid to streptozotocin‐diabetic rats restored impaired liver function by normalizing increased G6P and fructose‐1,6‐bisphosphatase (F6P) activity. In the same study, the acid increased insulin secretion and preserved pancreatic β‐cells function (Ji et al., 2020). Vanillic acid promoted the expression of p ‐Nrf2 and HO‐1 through LKB1/AMPK signaling pathway, reduced the production of ROS and MDA levels in human umbilical vein endothelial cells induced oxidative stress by fatty acid.…”

Section: Cabbage: a Food With Antidiabetic Bioactive Compoundsmentioning

confidence: 84%

Cabbage (Brassica oleracea var. capitata): A food with functional properties aimed to type 2 diabetes prevention and management

Narvaez

Campos

2021

Journal of Food Science

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Type 2 diabetes mellitus (T2DM) is increasing the prevalence worldwide at an alarming rate, becoming a serious public health problem that mainly affects developing countries. Functional food research is currently of great interest because it contributes to developing nutritional therapy strategies for T2DM prevention and treatment. Bioactive compounds identified in some plant foods contribute to human health by mechanisms of action that exert biological effects on metabolic pathways involved in the development of T2DM. Hence, vegetables with high bioactive compounds content may be a source of functional value for the control of T2DM. Cabbages varieties (Brassica oleracea var. capitata) such as green (GCB), white (WCB), and red (RCB) are foods consumed (raw or cooked) and cultivated in different regions of the world. Scientific evidence shows that cabbage has multi-target effects on glucose homeostatic regulation due to its high content of bioactive compounds. It has also been shown to decrease damage to organs affected by T2DM complications, such as the liver and kidney. Additionally, it could contribute as a preventive by attenuating problems underlying the development of T2DM as oxidative stress and obesity. This review highlights the functional properties of cabbage varieties involved in glucose regulation and the main mechanisms of the action exerted by their bioactive compounds. In conclusion, cabbage is a valuable food that can be employed as part of nutritional therapy or functional ingredient aimed at the prevention and treatment of T2DM.

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Vannilic acid ameliorates hyperglycemia-induced oxidative stress and inflammation in streptozotocin-induced diabetic rats

Cited by 16 publications

References 31 publications

L-carnitine Attenuates DNA Damage and Oxidative Stress in Diabetic Animals

L-carnitine Attenuates DNA Damage and Oxidative Stress in Diabetic Animals

Wogonin preventive impact on hippocampal neurodegeneration, inflammation and cognitive defects in temporal lobe epilepsy

Cabbage (Brassica oleracea var. capitata): A food with functional properties aimed to type 2 diabetes prevention and management

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