Vanishing hypercalciuric kidney stones after treating underlying acromegaly

Valk, Eline S van der; Tobe, T; Stades, Aline M.E.; Müller, Alex F.

doi:10.1530/edm-13-0001

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…In 57 newly diagnosed ACRO, hypertension was detected in 16 (28.1%) patients. Renal resistive index (RRI), an index that can reveal vascular and functional kidney abnormalities, was found to be higher in hypertensive compared to normotensive patients (p = 0.001), and, in regression analysis, IGF-1 was found to be independently associated with RRI [45]. Since RRI could be a preclinical index of hypertension and could be an early sign of hypertension development, renal Doppler US could be a useful exam in ACRO, especially given its non-invasive and costeffective nature.…”

Section: Kidneymentioning

confidence: 99%

“…Serious kidney involvement could be circumspect of acromegaly, in particular recurrent nephrolithiasis. Van der Valk et al suspected, and finally made a diagnosis of, acromegaly in a 53-year-old male who had excreted almost one renal calcium oxalate stone per month for the 18 months prior to diagnosis [45]. In a recent study, Bankir et al evaluated tissue elasticity in 40 ACRO compared to 20 healthy controls using share wave elastography (a non-invasive method that can give a quantitative measure of tissue elasticity), in organ size.…”

Section: Kidneymentioning

confidence: 99%

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Acromegaly and ultrasound: how, when and why?

Parolin

Dassiè

Vettor

et al. 2019

J Endocrinol Invest

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Background Acromegaly is a rare disease caused by an excess of growth hormone and insulin-like growth factor 1. It is usually diagnosed because of typical signs such as macroglossia, acral enlargement, jaw prognathism and malocclusion. Systemic complications are a major cause of morbidity and mortality in acromegaly, and many patients remain undiagnosed for several years. Increased ultrasound (US) application in the general population, and including among acromegaly patients, has revealed many suggestive features which, taken together with clinical suspicion, could induce suspicion of this disease. Purpose This review describes main US features in acromegaly. Echocardiography shows a typical cardiomyopathy, characterized by left ventricular hypertrophy, diastolic and systolic dysfunction, aortic and mitral regurgitation, and increased aortic root diameters. US preclinical markers of atherosclerosis, such as intima media thickness (IMT), seem also to be impaired. Visceromegaly and increased organ stiffness are other features of acromegaly, including enlarged prostate, kidneys, liver, and thyroid. In addition, other US findings are: renal cysts, micronephrolithiasis, impairment of renal haemodynamic parameters, gallstones and gallbladder polyps, hepatic steatosis, thyroid nodules, multinodular goiter, and polycystic ovaries. Musculoskeletal US findings are increased cartilage thickness, impaired density and elasticity of bones, nerve enlargement, carpal and cubital tunnel syndrome, and trigger finger. Conclusions Acromegaly patients frequently present systemic complications and a diagnostic delay. US features of acromegaly are not specific, but could potentially have a key role in early detection of the disease in the presence of typical clinical features.

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Section: Kidneymentioning

confidence: 99%

Section: Kidneymentioning

confidence: 99%

Acromegaly and ultrasound: how, when and why?

Parolin

Dassiè

Vettor

et al. 2019

J Endocrinol Invest

View full text Add to dashboard Cite

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“…Another study by van der Valk et al demonstrated the case of a 53-year-old male with recurrent kidney stones containing calcium oxalate. This was also one of the first symptoms of acromegaly, which subsequently resolved with proper treatment—somatostatin analogs followed by surgery [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Nephrolithiasis Treatment in Highest Reference Hospital—Occurrence of Acromegaly in the Study Group

Ząbkowski

Durma²,

Grabińska

et al. 2023

JCM

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Background: Urolithiasis is one of the most common diseases of the urinary system, the incidence of which is assumed to be up to 100,000 cases per million (10% of the population). The cause of it is dysregulation of renal urine excretion. Acromegaly is a very rare endocrine disorder that causes a somatotropic pituitary adenoma producing higher amounts of growth hormone. It occurs approximately in 80 cases per million (about 0.008% of the population). One of the acromegaly complications may be urolithiasis. Methods: Clinical and laboratory results of 2289 patients hospitalized for nephrolithiasis in the highest reference hospital were retrospectively analyzed, distinguishing a subgroup of patients with acromegaly. Statistical analysis was performed to compare the prevalence of the disease in the analyzed subgroup with the epidemiological results available in up-to-date literature. Results: The distribution of nephrolithiasis treatment was definitely in favor of non-invasive and minimally invasive treatment. The methods used were as follows: ESWL (61.82%), USRL (30.62%), RIRS (4.15%), PCNL (3.1%), and pyelolithotomy (0.31%). Such a distribution limited the potential complications of the procedures while maintaining the high effectiveness of the treatment. Among two thousand two hundred and eighty-nine patients with urolithiasis, two were diagnosed with acromegaly before the nephrological and urological treatment, and seven were diagnosed de novo. Patients with acromegaly required a higher percentage of open surgeries (including nephrectomy) and also had a higher rate of kidney stones recurrence. The concentration of IGF-1 in patients with newly diagnosed acromegaly was similar to those treated with somatostatin analogs (SSA) due to incomplete transsphenoidal pituitary surgery. Conclusions: In the population of patients with urolithiasis requiring hospitalization and interventional treatment compared to the general population, the prevalence of acromegaly was almost 50-fold higher (p = 0.025). Acromegaly itself increases the risk of urolithiasis.

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