Vanillin mitigates potassium bromate-induced molecular, biochemical and histopathological changes in the kidney of adult mice

Saad, Hajer Ben; Driss, Dorra; Chaabouni, Samia Ellouz; Boudawara, Tahia; Zeghal, Khaled Mounir; Hakim, Ahmed; Amara, Ibtissem Ben

doi:10.1016/j.cbi.2016.04.015

Cited by 17 publications

(15 citation statements)

References 48 publications

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“…The gastric sodium potassium pump is an (αβ) 2 transmembrane protein that is crucial for maintaining cell polarity via the Na + and k + membrane gradients (Georgios, 2002), and impaired Na + , k + -ATPase expression and activity has been reported in different pathologies (Mijatovic et al, 2012;Wang et al, 2017). We found increased Na + , k + -ATPase activity in potassium bromate-treated rats but this activity was diminished in the group exposed to potassium bromate and protocatechuic acid, suggesting the potential of both potassium bromate and protocatechuic acid to alter gastric cellular polarity, similar to reports of reduced Na + , k + -ATPase activity in organs of rats exposed to potassium bromate or protocatechuic acid (Campbell, 2006;Saad et al, 2016;Yin et al, 2009). Furthermore, high molecular weight mucins constitute the viscoelastic mucous gel that protects the luminal epithelium of the gut (Gendler & Andrew, 1995).…”

Section: Discussionsupporting

confidence: 89%

Potassium bromate cytotoxicity in the Wister rat model of chronic gastric ulcers: Possible reversal by protocatechuic acid

et al. 2020

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The affinity of xenobiotics for epithelial cells determine tissue and systemic toxicity expression. Humans come in contact with potassium bromate (KBrO 3 ; CAS. 7758-01-2) via exposure to mucus membrane and the skin when industrial workers inhale the white powdery substance or individuals use KBrO 3-containing cosmetics. (Alenius et al., 2014) Potassium bromate is also used as a food additive in baking, brewing, and cheese making (Emeje et al., 2010). Contact with KBrO 3 has been shown to predispose humans to central nervous system (CNS) perturbations like impaired thought pattern, deafness, and spasms, as well as systemic pathologies like renal malfunction, hypotension, cyanosis, methemoglobinemia, and cardiac arrhythmia

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Section: Discussionsupporting

confidence: 89%

Potassium bromate cytotoxicity in the Wister rat model of chronic gastric ulcers: Possible reversal by protocatechuic acid

et al. 2020

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“…During 15 days of the experimental period (Ben Saad et al, 2016), all groups were received ad libitum distilled water and standard diet (mixture of wheat, alfalfa, soybean, vitamins and minerals). Death was not observed in any experimental groups during the treatment period.…”

Section: Methodsmentioning

confidence: 99%

Effects of co-exposure to lead and zinc on redox status, kidney variables, and histopathology in adult albino rats

2018

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Lead (Pb) is a toxic metal that induces a wide range of biochemical and physiological effects in humans. Oxidative damage has been proposed as a possible mechanism involved in Pb toxicity. The current study was carried out to evaluate the antioxidant activities of zinc (Zn) supplement against lead acetate-induced kidney injury in rats. In this study, adults male rats were treated for 15 days with Pb (0.344 g/kg body weight (bw)) associated or not with Zn (10 mg/kg bw). Our study showed that supplementation with Zn prevented renal dysfunction as indicated by plasma biomarkers (urea, uric acid, creatinine, lactate dehydrogenase, and alkaline phosphatase levels) and oxidative stress-related parameters (thiobarbituric acid reactive substances, protein carbonyl, advanced oxidation protein product, superoxide dismutase, catalase, glutathione peroxidase, and vitamins (A, E)) in kidney tissue. The corrective effect of Zn on Pb-induced kidney nephrotoxicity recovered normal kidney histology. Overall, this study indicates that Zn alleviated the toxic effects of this heavy metal on renal tissue, suggesting its role as a potential antioxidant and nephroprotective agent.

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“…Moreover, pretreatment with vanillin (150 mg/kg) presented hepatoprotective effect against carbon tetrachloride-induced hepatotoxicity by the inhibition of protein and lipid oxidation processes, the increase in antioxidant enzymes activities, and the inhibition of inflammation mediators [25]. More recently, Ben Saad et al [26] demonstrated the protective effects of vanillin against potassium bromate- (KBrO 3 -) induced oxidative stress. The treatment with vanillin (100 mg/kg/day for 15 days) reduced histopathological changes in KBrO 3 -induced kidney and decreased renal oxidative damage by inhibiting ROS generation and reversing antioxidant enzyme activities in kidney [26].…”

Section: Antioxidant and Prooxidant Effectsmentioning

confidence: 99%

“…More recently, Ben Saad et al [26] demonstrated the protective effects of vanillin against potassium bromate- (KBrO 3 -) induced oxidative stress. The treatment with vanillin (100 mg/kg/day for 15 days) reduced histopathological changes in KBrO 3 -induced kidney and decreased renal oxidative damage by inhibiting ROS generation and reversing antioxidant enzyme activities in kidney [26]. These effects may be results of interactions between vanillin and cellular proteins or signaling pathways.…”

Section: Antioxidant and Prooxidant Effectsmentioning

confidence: 99%

Overview of the Role of Vanillin on Redox Status and Cancer Development

Bezerra

Soares

Sousa

2016

Oxidative Medicine and Cellular Longevity

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Bioactive natural products play critical roles in modern drug development, especially anticancer agents. It has been widely reported that various pharmacological activities of such compounds are related to their antioxidant properties. Vanillin is a natural substance widely found in many plant species and often used in beverages, foods, cosmetics, and pharmaceutical products. Antioxidant and anticancer potential have been described for this compound. Considering the importance of vanillin in the area of human health and food and pharmaceuticals sectors, in this review, we discuss the role of vanillin on redox status and its potential contribution to the prevention and the treatment of cancer.

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Vanillin mitigates potassium bromate-induced molecular, biochemical and histopathological changes in the kidney of adult mice

Cited by 17 publications

References 48 publications

Potassium bromate cytotoxicity in the Wister rat model of chronic gastric ulcers: Possible reversal by protocatechuic acid

Potassium bromate cytotoxicity in the Wister rat model of chronic gastric ulcers: Possible reversal by protocatechuic acid

Effects of co-exposure to lead and zinc on redox status, kidney variables, and histopathology in adult albino rats

Overview of the Role of Vanillin on Redox Status and Cancer Development

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