Vanillin Improves and Prevents Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice

Wu, Shih-Lu; Chen, Jaw-Chyun; Li, Chia-Cheng; Lo, Hsin-Yi; Ho, Tin-Yun; Hsiang, Chien-Yun

doi:10.1124/jpet.109.152835

Cited by 74 publications

(67 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, it was reported that vanillin exerts an anti-inflammatory activity in ICR mice, and the authors suggested that this is due to the release of inflammatory mediators being blocked during the first stage (72). A subsequent study further demonstrated the anti-inflammatory effect of vanillin during a treatment of inflammatory bowel diseases where vanillin prevented trinitrobenzene sulfonic acid-induced colitis and reduced established colitis in mice (73). Finally, vanillin decreased angiogenesis and showed protected against hepatocarcinogenesis (74), while also displaying anti-cancer properties as evidenced by its inhibition of matrix metalloproteinase-9 and P13K gene expression levels and regulation of the cell cycle and apoptosis in HepG2 cells, through which it suppressed the invasion and migration of cancer cells (66,75,76).…”

Section: Phenolic Aldehydes Resulting From Lignin Hydrolysismentioning

confidence: 88%

Biological activities of lignin hydrolysate-related compounds

Lee¹,

Monnappa²,

Mitchell³

2012

BMB Reports

View full text Add to dashboard Cite

Section: Phenolic Aldehydes Resulting From Lignin Hydrolysismentioning

confidence: 88%

Biological activities of lignin hydrolysate-related compounds

Lee¹,

Monnappa²,

Mitchell³

2012

BMB Reports

View full text Add to dashboard Cite

“…However, with improvement of the patient's condition, these parameters of oxidative stress go back to normal levels (178). As NF-B is a major inducer of inflammatory cytokines, the effect of a potent NF-B inhibitor, vanillin, has been studied in mouse model of colitis (325). Vanillin was shown to suppress the production of Th1 cytokines as well as scavenges 1 O 2 , underscoring its potential as a future treatment for IBD.…”

Section: Ibds (Ulcerative Colitis Crohn's Disease)mentioning

confidence: 99%

Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases

Bhattacharyya

Chattopadhyay

Mitra

et al. 2014

Physiological Reviews

1,785

1,258

View full text Add to dashboard Cite

Reactive oxygen species (ROS) are generated as by-products of normal cellular metabolic activities. Superoxide dismutase, glutathione peroxidase, and catalase are the enzymes involved in protecting cells from the damaging effects of ROS. ROS are produced in response to ultraviolet radiation, cigarette smoking, alcohol, nonsteroidal anti-inflammatory drugs, ischemia-reperfusion injury, chronic infections, and inflammatory disorders. Disruption of normal cellular homeostasis by redox signaling may result in cardiovascular, neurodegenerative diseases and cancer. ROS are produced within the gastrointestinal (GI) tract, but their roles in pathophysiology and disease pathogenesis have not been well studied. Despite the protective barrier provided by the mucosa, ingested materials and microbial pathogens can induce oxidative injury and GI inflammatory responses involving the epithelium and immune/inflammatory cells. The pathogenesis of various GI diseases including peptic ulcers, gastrointestinal cancers, and inflammatory bowel disease is in part due to oxidative stress. Unraveling the signaling events initiated at the cellular level by oxidative free radicals as well as the physiological responses to such stress is important to better understand disease pathogenesis and to develop new therapies to manage a variety of conditions for which current therapies are not always sufficient.

show abstract

“…Vanillin has been reported to exhibit multifunctional effects, including antimutagenic, [13][14][15] antiangiogenetic, 16) anti-colitis, 17) anti-sickling, 18) and antianalgesic effects. 19) Recently, we proposed the addition of antioxidant capacity to the multifunctionality of vanillin, 20) but the pharmacological action of ethyl vanillin has been little reported.…”

Section: Contents Of Ethyl Vanillin-and Vanillin-related Compounds Anmentioning

confidence: 99%

Antioxidant Properties of Ethyl Vanillinin Vitroandin Vivo

Tai¹,

Sawano²,

Yazama³

2011

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

We systematically evaluated the antioxidant activity of ethyl vanillin, a vanillin analog, as compared with the activities of vanillin and other vanillin analogs using multiple assay systems. Ethyl vanillin and vanillin exerted stronger antioxidant effects than did vanillyl alcohol or vanillic acid in the oxygen radical absorbance capacity (ORAC) assay, although the antioxidant activities of vanillyl alcohol and vanillic acid were clearly superior to those of ethyl vanillin and vanillin in the three model radical assays. The antioxidant activity of ethyl vanillin was much stronger than that of vanillin in the oxidative hemolysis inhibition assay, but was the same as that of vanillin in the ORAC assay. Oral administration of ethyl vanillin to mice increased the concentration of ethyl vanillic acid, and effectively raised antioxidant activity in the plasma as compared to the effect of vanillin. These data suggest that the antioxidant activity of ethyl vanillin might be more beneficial than has been thought in daily health practice.Key words: ethyl vanillin; ABTS radical cation; oxygen radical absorbance capacity (ORAC); oxidative hemolysis inhibition assay; plasma antioxidant activityThe association of reactive oxygen species and free radicals with many disease states is now well recognized, and antioxidants have attracted considerable attention.1,2) It has been reported that there are two types of antioxidants that scavenge radicals quickly and quench many radicals, and it has been proposed that reactivity should be assessed on the basis of both reaction rate and stoichiometry, 3) and that multiple methods should be used, since the activities of some antioxidants vary depending on the assay method.3-6) In addition, comparative studies using common antioxidants appear to be essential to clarify the biological significance of the activities of samples. We have assessed antioxidant activities with attention to the above-mentioned proposals and points of view. We found that 2-O--D-glucopyranosyl-L-ascorbic acid (AA-2G), a stable ascorbic acid derivative, exerted radical-scavenging activity toward unnatural model radicals, including DPPH radical [7][8][9][10] and ABTS radical cation (ABTS þ ). 9,11) The chemical properties of AA-2G as a radical scavenger were widely different from those of ascorbic acid, in that the reaction rate with these model radicals of AA-2G was much slower, but the long-term radical scavenging ability per molecule of AA-2G was superior to that of ascorbic acid. Recently, we reassessed the antioxidant activity of arbutin using five in vitro assay systems, though arbutin has been reported to possess weak antioxidant activity as compared to its precursor, hydroquinone.12) We found that arbutin exerted strong antioxidant activity, comparable or even superior to that of hydroquinone in the ABTS þ -scavenging assay, the ORAC assay, and two cell-based antioxidant assays.Vanillin is widely used in foods, beverages, cosmetics, and drugs. It has been reported to have multifunctional effects, including an...

show abstract

Vanillin Improves and Prevents Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice

Cited by 74 publications

References 39 publications

Biological activities of lignin hydrolysate-related compounds

Biological activities of lignin hydrolysate-related compounds

Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases

Antioxidant Properties of Ethyl Vanillinin Vitroandin Vivo

Contact Info

Product

Resources

About