Vanillin enhances the antibacterial and antioxidant properties of polyvinyl alcohol-chitosan hydrogel dressings

Xiong, Shuting; Li, Renpeng; Ye, Sheng; Ni, Peihong; Shan, Jing; Yuan, Tun; Liang, Jie; Fan, Yujiang; Zhang, Xingdong

doi:10.1016/j.ijbiomac.2022.08.052

Cited by 37 publications

(8 citation statements)

References 46 publications

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“…As a powerful antioxidant, vanillin shows cellular protective effects against oxidative stress [ 18 , 75 , 76 , 77 , 78 , 79 , 80 ]. Vanillin has a stronger antioxidant activity than ascorbic acid, and the authors suggested that the antioxidant activity of vanillin is beneficial for daily health care [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Vanillin Promotes Osteoblast Differentiation, Mineral Apposition, and Antioxidant Effects in Pre-Osteoblasts

Yun,

Kim,

Kwon

et al. 2024

Pharmaceutics

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Antioxidant vanillin (4-hydroxy-3-methoxybenzaldehyde) is used as a flavoring in foods, beverages, and pharmaceuticals. Vanillin possesses various biological effects, such as antioxidant, anti-inflammatory, antibacterial, and anticancer properties. This study aimed to investigate the biological activities of vanillin purified from Adenophora triphylla var. japonica Hara on bone-forming processes. Vanillin treatment induced mineralization as a marker for mature osteoblasts, after stimulating alkaline phosphatase (ALP) staining and activity. The bone-forming processes of vanillin are mainly mediated by the upregulation of the bone morphogenetic protein 2 (BMP2), phospho-Smad1/5/8, and runt-related transcription factor 2 (RUNX2) pathway during the differentiation of osteogenic cells. Moreover, vanillin promoted osteoblast-mediated bone-forming phenotypes by inducing migration and F-actin polymerization. Furthermore, we validated that vanillin-mediated bone-forming processes were attenuated by noggin and DKK1. Finally, we demonstrated that vanillin-mediated antioxidant effects prevent the death of osteoblasts during bone-forming processes. Overall, vanillin has bone-forming properties through the BMP2-mediated biological mechanism, indicating it as a bone-protective compound for bone health and bone diseases such as periodontitis and osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Vanillin Promotes Osteoblast Differentiation, Mineral Apposition, and Antioxidant Effects in Pre-Osteoblasts

Yun,

Kim,

Kwon

et al. 2024

Pharmaceutics

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“…Cell biocompatibility is a crucial property of biomaterials. 44,45 We selected L929, GES-1, HEEC, and HUVECs to evaluate the cell biocompatibility of the PEI/PAA/CS hydrogel. L929 cells and HUVECs are crucial for wound healing, and GES-1 cells and HEEC are two representative digestive tract cells.…”

Section: Discussionmentioning

confidence: 99%

A chitosan-optimized polyethyleneimine/polyacrylic acid multifunctional hydrogel for reducing the risk of ulcerative arterial bleeding

Xiong

et al. 2023

J. Mater. Chem. B

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“…Vanillin's positive properties on cell migration stimulation could be used in wound treatment formulations such as the hydrogel dressing with polyvinyl alcohol, chitosan, and vanillin developed by Xiong et al . [ 11 ] Vanillin thereby stimulates cell migration and speeds up the healing process of wounds, in addition to protecting cells from oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

The radical scavenging activity of vanillin and its impact on the healing properties of wounds

Changsan

Sinsuebpol²,

Burapapadh³

et al. 2023

J Adv Pharm Technol Res

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Vanillin, an extract from the Vanilla planifolia plant, is reported to possess potent antioxidant properties. The ability of vanillin to protect skin cells from reactive oxygen species (ROS)-induced damage and its potential use in the treatment of wounds were studied. Cytocompatibility and cytoprotective properties against ROS-induced damage were examined using keratinocyte and fibroblast cell models. Vanillin's effect on cell migration was studied using the scratch wound healing assay. Vanillin exhibited cytocompatibility and cytoprotective properties against cell damage induced by ROS. Human keratinocytes and fibroblast cells showed >80% survival when exposed to vanillin (10–500 μM). Both cells showed no evidence of necrosis or apoptosis, which was confirmed by acridine orange/propidium iodide staining. Both examined cells were exposed to 750 μM hydrogen peroxide to cause oxidative stress, and vanillin demonstrated the ability to inhibit ROS-induced cell death. In addition, a considerable increase in cell migration suggested that vanillin had the ability to heal wounds in vitro . Vanillin is safe and potentially useful in wound healing treatments.

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Vanillin enhances the antibacterial and antioxidant properties of polyvinyl alcohol-chitosan hydrogel dressings

Cited by 37 publications

References 46 publications

Vanillin Promotes Osteoblast Differentiation, Mineral Apposition, and Antioxidant Effects in Pre-Osteoblasts

Vanillin Promotes Osteoblast Differentiation, Mineral Apposition, and Antioxidant Effects in Pre-Osteoblasts

A chitosan-optimized polyethyleneimine/polyacrylic acid multifunctional hydrogel for reducing the risk of ulcerative arterial bleeding

The radical scavenging activity of vanillin and its impact on the healing properties of wounds

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