A chitosan-optimized polyethyleneimine/polyacrylic acid multifunctional hydrogel for reducing the risk of ulcerative arterial bleeding

Ni, Peihong; Ye, Sheng; Xiong, Shuting; Meng, Zhongyan; Shan, Jing; Yuan, Tun; Liang, Jie; Fan, Yujiang; Zhang, Xingdong

doi:10.1039/d3tb00239j

Cited by 7 publications

(5 citation statements)

References 51 publications

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“…First, the hydrogel effectively adhered to and sealed the bleeding wound, thereby halting bleeding through a physical barrier effect . Additionally, chitosan’s inherent hemostatic properties along with its positively charged quaternary ammonium groups facilitated erythrocyte aggregation and platelet adhesion …”

Section: Resultsmentioning

confidence: 99%

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Visible-Light Cross-Linkable Multifunctional Hydrogels Loaded with Exosomes Facilitate Full-Thickness Skin Defect Wound Healing through Participating in the Entire Healing Process

Lv,

Li,

Zhang

et al. 2024

ACS Appl. Mater. Interfaces

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The management of severe full-thickness skin defect wounds remains a challenge due to their irregular shape, uncontrollable bleeding, high risk of infection, and prolonged healing period. Herein, an all-in-one OD/GM/QCS@Exo hydrogel was prepared with catecholmodified oxidized hyaluronic acid (OD), methylacrylylated gelatin (GM), and quaternized chitosan (QCS) and loaded with adipose mesenchymal stem cell-derived exosomes (Exos). Cross-linking of the hydrogel was achieved using visible light instead of ultraviolet light irradiation, providing injectability and good biocompatibility. Notably, the incorporation of catechol groups and multicross-linked networks in the hydrogels conferred strong adhesion properties and mechanical strength against external forces such as tensile and compressive stress. Furthermore, our hydrogel exhibited antibacterial, anti-inflammatory, and antioxidant properties along with wound-healing promotion effects. Our results demonstrated that the hydrogel-mediated release of Exos significantly promotes cellular proliferation, migration, and angiogenesis, thereby accelerating skin structure reconstruction and functional recovery during the wound-healing process. Overall, the all-in-one OD/GM/QCS@Exo hydrogel provided a promising therapeutic strategy for the treatment of full-thickness skin defect wounds through actively participating in the entire process of wound healing.

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Section: Resultsmentioning

confidence: 99%

“…55 Additionally, chitosan's inherent hemostatic properties along with its positively charged quaternary ammonium groups facilitated erythrocyte aggregation and platelet adhesion. 56 3.3. Antibacterial, Biocompatibility, and Antioxidant Properties of Hydrogel.…”

Section: Tissue Adhesion and Hemostaticmentioning

confidence: 99%

Visible-Light Cross-Linkable Multifunctional Hydrogels Loaded with Exosomes Facilitate Full-Thickness Skin Defect Wound Healing through Participating in the Entire Healing Process

Lv,

Li,

Zhang

et al. 2024

ACS Appl. Mater. Interfaces

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“…The dry PEI/PAA has no adhesiveness, but its tissue adhesion can be triggered by water. After swelling by the water absorption, the wettability of PEI and PAA is induced, their molecular chains can move to bond with tissues through hydrogen bonding and electrostatic attraction at the interface 39,40 . TA‐gauze achieves efficient hemostasis partially due to the blood movement at the seam of gauze/tissue is retarded because of the adherence of PEI/PAA coating to wound tissue.…”

Section: Resultsmentioning

confidence: 99%

Modified cotton gauze with high hemostatic efficacy due to controllable hygroscopicity and wet tissue adhesiveness

Li,

Chen,

Huang

et al. 2024

J of Applied Polymer Sci

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In circumstances of severe traumatic bleeding, urgent bleeding control is vital to the wellness and life of the wounded person. Among many hemostatic measures, gauze is widely used because of cost‐effectiveness, safety and efficiency. However, it may suck a large amount of blood before bleeding stops. Thus, advanced hemostatic gauzes less blood loss and quick hemostatic rate and is greatly demanded. Herein, a novel tissue adhesive gauze (TA‐gauze) is developed by coating a thin layer of polyethyleneimine/poly(acrylic acid) (PEI/PAA) on the plain cotton gauze. This TA‐gauze has a reduced hydrophilicity and gets a new trait of wet tissue adhesiveness from the PEI/PAA coating layer. The TA‐gauze shows much improved hemostatic performance in the rat injury models, that is, its blood loss in the rat femoral artery model is just 13% that of the cotton gauze, due to it can retard the blood movement in the gauze and at the seam of gauze/tissue through a synergistic effect of tissue adhesion and hygroscopicity. It is biocompatible and on‐demand detachable. The simple preparation procedure and high hemostatic efficiency of the TA‐gauze may promise a bright future for an ideal hemostatic dressing for bleeding control.

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“…Not only this, some studies have pointed out that hemostatic hydrogels also have broad application prospects on the mucosal surface of the digestive tract. 104–106 Hydrogels adhere to wounds to stop bleeding. These hydrogels are better for emergency hemostasis in ruptured arteries or other fast bleeding.…”

Section: Physical Hemostasismentioning

confidence: 99%

Functional hemostatic hydrogels: design based on procoagulant principles

Zhang,

Wang,

Tian

et al. 2024

J. Mater. Chem. B

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A chitosan-optimized polyethyleneimine/polyacrylic acid multifunctional hydrogel for reducing the risk of ulcerative arterial bleeding

Abstract: Ulcerative arterial bleeding is characterized by sudden onset, rapid disease development and high mortality, which is a great challenge for clinicians to treat, specially bleeding in areas where endoscopic operation...

Cited by 7 publications

References 51 publications

Visible-Light Cross-Linkable Multifunctional Hydrogels Loaded with Exosomes Facilitate Full-Thickness Skin Defect Wound Healing through Participating in the Entire Healing Process

Visible-Light Cross-Linkable Multifunctional Hydrogels Loaded with Exosomes Facilitate Full-Thickness Skin Defect Wound Healing through Participating in the Entire Healing Process

Modified cotton gauze with high hemostatic efficacy due to controllable hygroscopicity and wet tissue adhesiveness

Functional hemostatic hydrogels: design based on procoagulant principles

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